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作者：[Anonymous]
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作者：Hargreaves, Anna L.; Alexander, Jake M.
作者单位：McGill University; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：Children are often taught about the natural world through facts about species, such as what a toucan eats. Yet species are not homogeneous, and different populations within a species vary in how they use their environment. Gaining a better understanding of this variation is a key challenge in ecology. One idea is that niche variation should be particularly apparent toward the edges of species' geographic distributions, where the amount or quality of habitat declines ( 1 ). However, there is li...
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作者：Zhang, Chonghe; Cummins, Christopher C.; Gilliard Jr, Robert J.
作者单位：Massachusetts Institute of Technology (MIT)
摘要：Diazo compounds and organic azides are widely used as reagents for accessing valuable molecules in multiple areas of fundamental and applied chemistry. Their capacity to undergo versatile chemical transformations arises from the reactive nature of an incipient dinitrogen molecule at the terminal position. In this work, we report the synthesis and characterization of an N-heterocyclic carbene (NHC)-stabilized diazoborane-a boron-centered analog of organic azides and diazoalkanes. The diazoboran...
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作者：Li, Liming; Comi, Troy J.; Bierman, Rob F.; Akey, Joshua M.
作者单位：Southeast University - China; Princeton University
摘要：Although it is well known that the ancestors of modern humans and Neanderthals admixed, the effects of gene flow on the Neanderthal genome are not well understood. We develop methods to estimate the amount of human-introgressed sequences in Neanderthals and apply it to whole-genome sequence data from 2000 modern humans and three Neanderthals. We estimate that Neanderthals have 2.5 to 3.7% human ancestry, and we leverage human-introgressed sequences in Neanderthals to revise estimates of Neande...
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作者：Cohen, Jon
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作者：Lewis, Nicola; Beer, Martin
作者单位：Francis Crick Institute; Friedrich Loeffler Institute
摘要：The relentless march of a highly pathogenic avian influenza virus (HPAIV) strain, known as H5N1, to become an unprecedented panzootic continues unchecked. The leap of H5N1 clade 2.3.4.4b from Eurasia and Africa to North America in 2021 and its further spread to South America and the Antarctic have exposed new avian and mammalian populations to the virus and led to outbreaks on an unrivaled scale. The virus has infected wild birds across vast geographic regions and caused wildlife deaths in som...
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作者：Black, Amanda; Tylianakis, Jason M.
作者单位：Lincoln University - New Zealand; University of Canterbury
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作者：Fang, Yiqi; Kuttruff, Joel; Nabben, David; Baum, Peter
作者单位：University of Konstanz
摘要：Chirality is a phenomenon with widespread relevance in fundamental physics, material science, chemistry, optics, and spectroscopy. In this work, we show that a free electron can be converted by the field cycles of laser light into a right-handed or left-handed coil of mass and charge. In contrast to phase-vortex beams, our electrons maintained a flat de Broglie wave but obtained their chirality from the shape of their expectation value in space and time. Measurements of wave function densities...
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作者：Wu, Meng-Ju; Kondo, Hiroshi; Kammula, Ashwin V.; Shi, Lei; Xiao, Yi; Dhiab, Sofiene; Xu, Qin; Slater, Chloe J.; Avila, Omar I.; Merritt, Joshua; Kato, Hiroyuki; Kattel, Prabhat; Sussman, Jonathan; Gritti, Ilaria; Eccleston, Jason; Sun, Yi; Cho, Hyo Min; Olander, Kira; Katsuda, Takeshi; Shi, Diana D.; Savani, Milan R.; Smith, Bailey C.; Cleary, James M.; Mostoslavsky, Raul; Vijay, Vindhya; Kitagawa, Yosuke; Wakimoto, Hiroaki; Jenkins, Russell W.; Yates, Kathleen B.; Paik, Jihye; Tassinari, Ania; Saatcioglu, Duygu Hatice; Tron, Adriana E.; Haas, Wilhelm; Cahill, Daniel; Mcbrayer, Samuel K.; Manguso, Robert T.; Bardeesy, Nabeel
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of Texas System; University of Texas Southwestern Medical Center; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Gustave Roussy; Universite Paris Saclay; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of Texas System; University of Texas Southwestern Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Cornell University; Weill Cornell Medicine; University of Texas System; University of Texas Southwestern Medical Center
摘要：Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A hallmark of IDH1-mutant solid tumors is T cell exclusion, whereas mIDH1 inhibition in preclinical models restores antitumor immunity. Here, we define a cell-autonomous mechanism of mIDH1-driven immune evasion. IDH1-mutant solid tumors show selective hypermeth...
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作者：Stone, Richard
