6745期

最新文章

• The cellular basis for middle-age spread AI翻译
  作者：Jeon, Yong Geun; Kim, Jae Bum
  作者单位：Seoul National University (SNU)
• Tumor-derived erythropoietin acts as an immunosuppressive switch in cancer immunity AI翻译
  作者：Chiu, David Kung-Chun; Zhang, Xiangyue; Cheng, Bowie Yik-Ling; Liu, Qiang; Hayashi, Kazukuni; Yu, Bo; Lee, Ryan; Zhang, Catherine; An, Xiuli; Rajadas, Jayakumar; Reticker-Flynn, Nathan E.; Rankin, Erinn B.; Engleman, Edgar G.
  作者单位：Stanford University; Stanford University; Stanford University; New York Blood Center; Stanford University; Stanford University; Stanford University; Stanford Cancer Institute
  摘要：Successful cancer immunotherapy requires a patient to mount an effective immune response against tumors; however, many cancers evade the body's immune system. To investigate the basis for treatment failure, we examined spontaneous mouse models of hepatocellular carcinoma (HCC) with either an inflamed T cell-rich or a noninflamed T cell-deprived tumor microenvironment (TME). Our studies reveal that erythropoietin (EPO) secreted by tumor cells determines tumor immunotype. Tumor-derived EPO auton...
• Hawaiian caterpillar patrols spiderwebs camouflaged in insect prey's body parts AI翻译
  作者：Rubinoff, Daniel; San Jose, Michael; Doorenweerd, Camiel
  作者单位：University of Hawaii System; University of Hawaii Manoa
  摘要：Lepidoptera is the most herbivorous of all the insect orders, with predatory caterpillars globally comprising less than 0.13% of the nearly 200,000 moth and butterfly species. Here, we report a species in which caterpillars are carnivorous inhabitants of spider's webs, feeding on the arthropods that they find there. This Hawaiian lineage also boasts an unprecedented and macabre practice of decorating its portable larval home with the body parts of the spider prey it harvests from the web where...
• Ultracool microscopes advance AI翻译
  作者：Servick, Kelly
• Distinct adipose progenitor cells emerging with age drive active adipogenesis AI翻译
  作者：Wang, Guan; Li, Gaoyan; Song, Anying; Zhao, Yutian; Yu, Jiayu; Wang, Yifan; Dai, Wenting; Salas, Martha; Qin, Hanjun; Medrano, Leonard; Dow, Joan; Li, Aimin; Armstrong, Brian; Fueger, Patrick T.; Yu, Hua; Zhu, Yi; Shao, Mengle; Wu, Xiwei; Jiang, Lei; Campisi, Judith; Yang, Xia; Wang, Qiong A.
  作者单位：City of Hope; University of California System; University of California Los Angeles; City of Hope; City of Hope; City of Hope; City of Hope; City of Hope; City of Hope; Beckman Research Institute of City of Hope; Baylor College of Medicine; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Buck Institute for Research on Aging; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Starting at middle age, adults often suffer from visceral adiposity and associated adverse metabolic disorders. Lineage tracing in mice revealed that adipose progenitor cells (APCs) in visceral fat undergo extensive adipogenesis during middle age. Thus, despite the low turnover rate of adipocytes in young adults, adipogenesis is unlocked during middle age. Transplantations quantitatively showed that APCs in middle-aged mice exhibited high adipogenic capacity cell-autonomously. Single-cell RNA ...
• Sex Is a Spectrum: The Biological Limits of the Binary AI翻译
  作者：Ah-King, Malin
  作者单位：Orebro University; Orebro University
• Reimagining silicone's life cycle AI翻译
  作者：Ghosh, Koushik
  作者单位：United States Department of Energy (DOE); Sandia National Laboratories
• Partisan disparities in the use of science in policy AI翻译
  作者：Furnas, Alexander C.; LaPira, Timothy M.; Wang, Dashun
  作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; James Madison University; Northwestern University
• RNA-mediated CRISPR-Cas13 inhibition through crRNA structural mimicry AI翻译
  作者：Hayes, Victoria M.; Zhang, Jun-Tao; Katz, Mark A.; Li, Yuelong; Kocsis, Benjamin; Brinkley, David M.; Jia, Ning; Meeske, Alexander J.
  作者单位：University of Washington; University of Washington Seattle; Southern University of Science & Technology; Southern University of Science & Technology
  摘要：To circumvent CRISPR-Cas immunity, phages express anti-CRISPR factors that inhibit the expression or activities of Cas proteins. Whereas most anti-CRISPRs described to date are proteins, recently described small RNAs called RNA anti-CRISPRs (rAcrs) have sequence homology to CRISPR RNAs (crRNAs) and displace them from cognate Cas nucleases. In this work, we report the discovery of rAcrVIA1-a plasmid-encoded small RNA that inhibits the RNA-targeting CRISPR-Cas13 system in its natural host, Liste...
• A well-connected Earth: The science and conservation of organismal movement AI翻译
  作者：Brodie, Jedediah F.; Gonzalez, Andrew; Mohd-Azlan, Jayasilan; Nelson, Cara R.; Tabor, Gary; Vasudev, Divya; Zeller, Katherine A.; Fletcher, Robert J., Jr.
  作者单位：University of Montana System; University of Montana; University of Montana System; University of Montana; University of Malaysia Sarawak; McGill University; University of Montana System; University of Montana; Cornell University; United States Department of Agriculture (USDA); United States Forest Service; State University System of Florida; University of Florida; University of Cambridge
  摘要：Global biodiversity targets focus on landscape and seascape connectivity as a foundational component of biodiversity conservation, including networks of connected protected areas. Recent advances allow the measurement and prediction of organismal movements at multiple scales. We provide a definition of connectivity that links movement to persistence and ecological function. Connectivity science can guide planning for biodiversity, ecosystem services, ecological restoration, and climate adaptat...