作者：Lefton, Katheryn B.; Wu, Yifan; Dai, Yanchao; Okuda, Takao; Zhang, Yufen; Yen, Allen; Rurak, Gareth M.; Walsh, Sarah; Manno, Rachel; Myagmar, Bat-Erdene; Dougherty, Joseph D.; Samineni, Vijay K.; Simpson, Paul C.; Papouin, Thomas
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of California System; University of California San Francisco; US Department of Veterans Affairs; Veterans Health Administration (VHA); San Francisco VA Medical Center; University of California System; University of California San Francisco; Washington University (WUSTL)
摘要：Locus ceruleus (LC)-derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level mechanisms are elusive. Here, we show that NE remodeling of synaptic function is completely independent from its binding on neuronal receptors. Instead, astrocytic adrenergic receptors and calcium dynamics fully gate the effect of NE on synapses. Additionally, we found that NE suppression of syna...
作者：Joy, Sandeep; Skinner, Brian
作者单位：State University System of Florida; Florida State University; State University System of Florida; Florida State University; University System of Ohio; Ohio State University
作者：Pande, Rohini
作者单位：Yale University; Yale University
作者：Zhou, Jie; Yuen, Kwok Yung
作者单位：University of Hong Kong; University of Hong Kong
作者：Nunes, Kelly; Castro e Silva, Marcos Araujo; Rodrigues, Maira R.; Lemes, Renan Barbosa; Pezo-Valderrama, Patricio; Kimura, Lilian; de Sena, Lucas Schenatto; Krieger, Jose Eduardo; Varela, Margareth Catoia; de Azevedo, Luiz Otavio; Camargo, Luis Marcelo Aranha; Ferreira, Ricardo G. M.; Krieger, Henrique; Bortolini, Maria Catira; Mill, Jose Geraldo; Sacuena, Putira; Guerreiro, Joao F.; de Souza, Celia M. B.; Veronese, Francisco V.; Vianna, Fernanda S. L.; Comas, David; Pereira, Alexandre C.; Pereira, Lygia V.; Hunemeier, Tabita
作者单位：Universidade de Sao Paulo; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; Universidade de Sao Paulo; Fundacao Oswaldo Cruz; Fundacao Oswaldo Cruz; Universidade de Sao Paulo; Universidade Federal do Rio Grande do Sul; Universidade Federal do Espirito Santo; Universidade Federal do Para; Hospital de Clinicas de Porto Alegre; Harvard University; Harvard Medical School
摘要：Brazil, the largest Latin American country, is underrepresented in genomic research despite boasting the world's largest recently admixed population. In this study, we generated 2723 high-coverage whole-genome sequences from the Brazilian population, including urban, rural, and riverine communities representing diverse ethnic backgrounds. We reveal the impressive genomic diversity of Brazilians, identifying >8 million previously unknown variants, including 36,637 predicted deleterious and pote...
作者：Monteiro, Lara de Macedo
作者单位：University of Vermont
