作者：Gusareva, Elena S.; Ghosh, Amit Gourav; Kharkov, Vladimir N.; Khor, Seik-Soon; Zarubin, Aleksei; Moshkov, Nikita; Kalsi, Namrata; Ratan, Aakrosh; Heinle, Cassie E.; Cooke, Niall; Bravi, Claudio M.; Smolnikova, Marina V.; Tereshchenko, Sergey Yu.; Kasparov, Eduard W.; Khitrinskaya, Irina; Marusin, Andrey; Razhabov, Magomed O.; Golubenko, Maria V.; Swarovskaya, Maria; Kolesnikov, Nikita A.; Vagaitseva, Ksenia V.; Eremina, Elena R.; Sukhomyasova, Aitalina; Shtygasheva, Olga; Panicker, Deepa; Ang, Poh Nee; Lee, Choou Fook; Koh, Yanqing; Leong, See Ting; Park, Changsook; Lohar, Sachin R.; Yap, Zhei Hwee; Ng, Soo Guek; Dacanay, Justine; Drautz-Moses, Daniela I.; Ramli, Nurul Adilah Binte; Tokunaga, Katsushi; Mcgonigle, Ian; Danjoh, Inaho; Moreno-Estrada, Andres; Tajima, Atsushi; Tanabe, Hideyuki; Nakamura, Yukio; Nakagome, Shigeki; Tatarinova, Tatiana V.; Stepanov, Vadim A.; Schuster, Stephan C.; Kim, Hie Lim
作者单位：Nanyang Technological University; Nanyang Technological University; Russian Academy of Sciences; Tomsk National Research Medical Center; Research Institute of Medical Genetics - Tomsk; Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan; HUN-REN; HUN-REN Biological Research Center; University of Virginia; Trinity College Dublin; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Russian Academy of Sciences; Krasnoyarsk Science Center of the Siberian Branch of the Russian Academy of Sciences; Research Institute for Medical Problems in the North, Siberian Branch, Russian Academy of Sciences; Siberian Branch of the Russian Academy of Sciences; Amirkhanov Institute of Physics, Daghestan Federal Research Centre of the Russian Academy of Sciences; Buryat State University; North-Eastern Federal University in Yakutsk; Katanov Khakass State University; Nanyang Technological University; Nanyang Technological University; Maynooth University; Tohoku University; Kanazawa University; Kanazawa University; Graduate University for Advanced Studies - Japan; RIKEN; University of La Verne; Nanyang Technological University
摘要：INTRODUCTION: During the late Pleistocene, humans expanded across Eurasia and eventually migrated to the Americas. Those who reached Patagonia, at the southern tip of South America, completed the longest migration out of Africa. RATIONALE: The extent of basal divergences, admixture, and degrees of isolation among Indigenous North Eurasian and Native South American populations remain debated, with most insights derived from genome-wide genotyping data. This study aims to deepen our understandin...
作者：Moynihan, Donald; Herd, Pamela
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
作者：Wu, Feng-Jie; Rieder, Pascal S.; Abiko, Layara Akemi; Grahl, Anne; Haeussinger, Daniel; Grzesiek, Stephan
作者单位：University of Basel; University of Basel
摘要：The regulation of G protein-coupled receptor signaling by different orthosteric ligands is thought to occur through shifts in dynamically interconverting, conformational distributions. Such changes in dynamical distributions have been detected so far only by very sparse, often non-native experimental probes at low resolution. Using a recently developed paramagnetic nuclear magnetic resonance (NMR) method, we could assign and follow 81 H-1-N-15 NMR correlations in the beta(1)-adrenergic recepto...
作者：Arevalo-Ayala, Diego J.; Funes, Guillermo; Pablo-Cea, Jose D.
作者单位：University of Barcelona; Universidad de El Salvador
作者：Peng, Ruchao; Xu, Xin; Nepal, Binod; Gong, Yikang; Li, Fenglin; Ferretti, Max B.; Zhou, Mingyang; Lynch, Kristen W.; Burslem, George M.; Kortagere, Sandhya; Marmorstein, Ronen; Chang, Yi-Wei
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Drexel University; University of Pennsylvania
摘要：Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo-electron microscopy single-particle analysis and cryo-electron tomography, we define the influenza RNP as a right-handed, antiparallel double helix with the viral RNA encapsidated in the minor groove. Individual nucleoprotein subunits are connected by a flexible tail loop that inserts into a conserved pocket in its neighbor. We visualize the viral polymeras...
作者：Chen, Yi-Hsiu; Lenoir, Jonathan; Chen, I-Ching
作者单位：National Cheng Kung University; Universite de Picardie Jules Verne (UPJV)
摘要：Mountain biodiversity reorganizes rapidly as species shift upslope to track temperatures. Pervasive species redistribution poses substantial threats to mountain ecosystems, a phenomenon sometimes described as an escalator to extinction, primarily through mountaintop extinctions, range shift gaps (i.e., rapid shifts of suitable temperatures getting ahead of narrow-range species' upper limits), and lowland biodiversity attrition, yet empirical evidence remains scarce. In this study, our analysis...
