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作者：Fernandez, Maria Emilia; Bernier, Michel; Price, Nathan L.; Camandola, Simonetta; Aon, Miguel A.; Vaughan, Kelli; Mattison, Julie A.; Preston, Joshua D.; Jones, Dean P.; Tanaka, Toshiko; Tian, Qu; Gonzalez-Freire, Marta; Ferrucci, Luigi; de Cabo, Rafael
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); Emory University; Emory University; Emory University; Institut Investigacio Sanitaria Illes Balears (IdISBa)
摘要：Low circulating taurine concentrations have been proposed as a driver of the aging process. We found that circulating taurine concentrations increased or remained unchanged with age in three geographically distinct human cohorts as well as in nonhuman primates and mice when measured longitudinally (repeatedly in the same population) or cross-sectionally (sampling distinct populations at various ages). Moreover, considerable variability was observed in associations between taurine and age-relat...
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作者：Asthana, Anushweta; Jackson, Peter K.
作者单位：Stanford University
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作者：Mcleester, Madeleine; Ferwerda, Carolin; Alperstein, Jonathan; Overstreet, David; Grignon, David; Casana, Jesse
作者单位：Dartmouth College; College of Menominee Nation
摘要：We describe archaeological evidence of intensive ancestral Native American agriculture in the now heavily forested Upper Peninsula of Michigan. Recent LIDAR (light detection and ranging) and excavation data have uncovered densely clustered ancient agricultural raised garden bed ridges covering an expanse far greater than previously realized. These raised agricultural fields are deeply enmeshed in the broader cultural landscape, as ceremonial and other features were also found. Our results demo...
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作者：Sia, Youyang; Pan, Han; Chen, Kangjing; Chen, Zhucheng
作者单位：Tsinghua University; Tsinghua University
摘要：Chromatin remodelers utilize the energy of adenosine triphosphate (ATP) hydrolysis to slide nucleosomes, regulating chromatin structure and gene activity in cells. In this work, we report structures of imitation switch (ISWI) bound to the nucleosome during active ATP hydrolysis and remodeling, revealing conformational transitions of the remodeling motor across the adenosine triphosphatase (ATPase) cycle. The DNA strands were distorted accordingly, showing one full base-pair bulge and a loss of...
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作者：Usami, Atsushi; Kono, Hideya; Austen, Vic; Phung, Quan Manh; Shudo, Hiroki; Kato, Tomoki; Yamada, Hayato; Yagi, Akiko; Amaike, Kazuma; Fujimoto, Kazuhiro J.; Yanai, Takeshi; Itami, Kenichiro
作者单位：Nagoya University; Nagoya University; Nagoya University; Nagoya University; RIKEN; RIKEN
摘要：Many functional molecules and materials have been produced with organic chemistry or with in vitro enzymatic approaches. Individual organisms, such as insects, have the potential to serve as natural reaction platforms in which high densities of multiple enzymes can perform new and complex reactions. We report an in-insect unnatural product synthesis that takes advantage of their xenobiotic metabolism. We selectively transform belt- and ring-shaped molecular nanocarbons into otherwise difficult...
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作者：Wang, Shuiyuan; Jiang, Chengyong; Yu, Yiye; Zhang, Zhenhan; Quhe, Ruge; Yang, Ruyi; Tian, Yufei; Chen, Xindong; Fan, Wenqiang; Niu, Yinge; Yan, Biao; Jiang, Chunhui; Wang, Yang; Wang, Zhen; Liu, Chunsen; Hu, Weida; Zhang, Jiayi; Zhou, Peng
作者单位：Fudan University; Chinese Academy of Sciences; Shanghai Institute of Technical Physics, CAS; Nanyang Technological University; Beijing University of Posts & Telecommunications; Beijing University of Posts & Telecommunications
摘要：Present vision restoration technologies have substantial constraints that limit their application in the clinical setting. In this work, we fabricated a subretinal nanoprosthesis using tellurium nanowire networks (TeNWNs) that converts light of both the visible and near-infrared-II spectra into electrical signals. The broad-spectrum coverage is made possible by a combination of narrow bandgaps, strong absorption, and engineered asymmetries. Implanted into blind mice, the TeNWNs restored pupill...
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作者：Reardon, Sara
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作者：Gerber, Leah R.; Davis, Katrina
作者单位：Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; University of Oxford
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作者：Yoon, Sun Geun; Vishnugopi, Bairav S.; Nelson, Douglas Lars; Yong, Adrian Xiao Bin; Wang, Yingjin; Sandoval, Stephanie Elizabeth; Thomas, Talia A.; Cavallaro, Kelsey Anne; Shevchenko, Pavel; Alsac, Elif Pinar; Wang, Congcheng; Singla, Aditya; Greer, Julia R.; Ertekin, Elif; Mukherjee, Partha P.; McDowell, Matthew T.
作者单位：University System of Georgia; Georgia Institute of Technology; Purdue University System; Purdue University; Purdue University in Indianapolis; University System of Georgia; Georgia Institute of Technology; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; California Institute of Technology; United States Department of Energy (DOE); Argonne National Laboratory; University of Illinois System; University of Illinois Urbana-Champaign
摘要：The complex morphological evolution of lithium metal at the solid-state electrolyte interface limits performance of solid-state batteries, leading to inhomogeneous reactions and contact loss. Inspired by biological morphogenesis, we developed an interfacial self-regulation concept in which a deformable secondary phase dynamically aggregates at the interface in response to local electro-chemo-mechanical stimuli, enhancing contact. The stripping of a lithium electrode that contains 5 to 20 mole ...
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作者：Wadman, Meredith
