Tellurium nanowire retinal nanoprosthesis improves vision in models of blindness

• 成果类型: Article
• 署名作者: Wang, Shuiyuan; Jiang, Chengyong; Yu, Yiye; Zhang, Zhenhan; Quhe, Ruge; Yang, Ruyi; Tian, Yufei; Chen, Xindong; Fan, Wenqiang; Niu, Yinge; Yan, Biao; Jiang, Chunhui; Wang, Yang; Wang, Zhen; Liu, Chunsen; Hu, Weida; Zhang, Jiayi; Zhou, Peng
• 署名单位: Fudan University; Chinese Academy of Sciences; Shanghai Institute of Technical Physics, CAS; Nanyang Technological University; Beijing University of Posts & Telecommunications; Beijing University of Posts & Telecommunications
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-11133
• DOI: 10.1126/science.adu2987
• 发表日期: 2025-06-05
• 关键词: field-effect transistors; ganglion-cells; visual-cortex; cone types; light; restoration; responses; degeneration; therapy; flicker

摘要

Present vision restoration technologies have substantial constraints that limit their application in the clinical setting. In this work, we fabricated a subretinal nanoprosthesis using tellurium nanowire networks (TeNWNs) that converts light of both the visible and near-infrared-II spectra into electrical signals. The broad-spectrum coverage is made possible by a combination of narrow bandgaps, strong absorption, and engineered asymmetries. Implanted into blind mice, the TeNWNs restored pupillary reflexes and enabled visually cued learning under visible and near-infrared 1550-nanometer light. In nonhuman primates, TeNWNs elicited robust retina-derived neural responses, confirming biocompatibility and feasibility. By restoring lost photosensitivity and extending vision to near-infrared, this nanoprosthesis offers a promising approach for restoring vision.