Is taurine an aging biomarker?

• 成果类型: Article
• 署名作者: Fernandez, Maria Emilia; Bernier, Michel; Price, Nathan L.; Camandola, Simonetta; Aon, Miguel A.; Vaughan, Kelli; Mattison, Julie A.; Preston, Joshua D.; Jones, Dean P.; Tanaka, Toshiko; Tian, Qu; Gonzalez-Freire, Marta; Ferrucci, Luigi; de Cabo, Rafael
• 署名单位: National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); Emory University; Emory University; Emory University; Institut Investigacio Sanitaria Illes Balears (IdISBa)
• 刊物名称: SCIENCE
• ISSN/ISSBN: 0036-10895
• DOI: 10.1126/science.adl2116
• 发表日期: 2025-06-05
• 关键词: amino-acid-concentrations; dietary taurine; whole-blood; plasma; serum; cholesterol; muscle; glucose; HEALTH; RESTRICTION

摘要

Low circulating taurine concentrations have been proposed as a driver of the aging process. We found that circulating taurine concentrations increased or remained unchanged with age in three geographically distinct human cohorts as well as in nonhuman primates and mice when measured longitudinally (repeatedly in the same population) or cross-sectionally (sampling distinct populations at various ages). Moreover, considerable variability was observed in associations between taurine and age-related changes in health outcomes pertaining to gross motor function and energy homeostasis. Our results suggest that changes in circulating taurine are not a universal feature of aging and that its pleiotropic effects may be dependent on the temporal and physiological context of each individual.