7996期

最新文章

• Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage AI翻译
  作者：Yoon, Jin-Hui; Jin, Hokyung; Kim, Hae Jin; Hong, Seon Pyo; Yang, Myung Jin; Ahn, Ji Hoon; Kim, Young-Chan; Seo, Jincheol; Lee, Yongjeon; Mcdonald, Donald M.; Davis, Michael J.; Koh, Gou Young
  作者单位：Institute for Basic Science - Korea (IBS); Korea Advanced Institute of Science & Technology (KAIST); University of Missouri System; University of Missouri Columbia; Korea Research Institute of Bioscience & Biotechnology (KRIBB); University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center
  摘要：Cerebrospinal fluid (CSF) in the subarachnoid space around the brain has long been known to drain through the lymphatics to cervical lymph nodes1-17, but the connections and regulation have been challenging to identify. Here, using fluorescent CSF tracers in Prox1-GFP lymphatic reporter mice18, we found that the nasopharyngeal lymphatic plexus is a major hub for CSF outflow to deep cervical lymph nodes. This plexus had unusual valves and short lymphangions but no smooth-muscle coverage, wherea...
• Spatial IMA1 regulation restricts root iron acquisition on MAMP perception AI翻译
  作者：Cao, Min; Platre, Matthieu Pierre; Tsai, Huei-Hsuan; Zhang, Ling; Nobori, Tatsuya; Armengot, Laia; Chen, Yintong; He, Wenrong; Brent, Lukas; Coll, Nuria S.; Ecker, Joseph R.; Geldner, Niko; Busch, Wolfgang
  作者单位：Salk Institute; University of Lausanne; Salk Institute; Howard Hughes Medical Institute; Salk Institute; Consejo Superior de Investigaciones Cientificas (CSIC); Centre de Recerca en Agrigenomica (CRAG); University of Barcelona; Autonomous University of Barcelona; IRTA; University of Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); Salk Institute
  摘要：Iron is critical during host-microorganism interactions1-4. Restriction of available iron by the host during infection is an important defence strategy, described as nutritional immunity5. However, this poses a conundrum for externally facing, absorptive tissues such as the gut epithelium or the plant root epidermis that generate environments that favour iron bioavailability. For example, plant roots acquire iron mostly from the soil and, when iron deficient, increase iron availability through...
• Coping with climate change could be a matter of what building you're in AI翻译
  作者：Evans, Meredydd
  作者单位：United States Department of Energy (DOE); Pacific Northwest National Laboratory
  摘要：Extreme heat and cold brought on by climate change put people at risk. Beefing up building codes now could help to save lives.
• Conserved and divergent gene regulatory programs of the mammalian neocortex (vol 624, pg 390, 2023) AI翻译
  作者：Zemke, Nathan R.; Armand, Ethan J.; Wang, Wenliang; Lee, Seoyeon; Zhou, Jingtian; Li, Yang Eric; Liu, Hanqing; Tian, Wei; Nery, Joseph R.; Castanon, Rosa G.; Bartlett, Anna; Osteen, Julia K.; Li, Daofeng; Zhuo, Xiaoyu; Xu, Vincent; Chang, Lei; Dong, Keyi; Indralingam, Hannah S.; Rink, Jonathan A.; Xie, Yang; Miller, Michael; Krienen, Fenna M.; Zhang, Qiangge; Taskin, Naz; Ting, Jonathan; Feng, Guoping; Mccarroll, Steven A.; Callaway, Edward M.; Wang, Ting; Lein, Ed S.; Behrens, M. Margarita; Ecker, Joseph R.; Ren, Bing
• Flexible geothermal power makes it easier to harness Earth's inner heat AI翻译
  作者：[Anonymous]
• Probing supernovae and kicks in post-supernova binaries AI翻译
  作者：Larsen, C.; Larsen, H. C. G.; Pedersen, C. C.; Thomsen, P. N.; Toffner-Clausen, J.; Tauris, T. M.
  作者单位：Aalborg University
• How I make stretchy electronics for medicine AI翻译
  作者：Noronha, Patricia Maia
• Negative mixing enthalpy solid solutions deliver high strength and ductility AI翻译
  作者：An, Zibing; Li, Ang; Mao, Shengcheng; Yang, Tao; Zhu, Lingyu; Wang, Rui; Wu, Zhaoxuan; Zhang, Bin; Shao, Ruiwen; Jiang, Cheng; Cao, Boxuan; Shi, Caijuan; Ren, Yang; Liu, Cheng; Long, Haibo; Zhang, Jianfei; Li, Wei; He, Feng; Sun, Ligang; Zhao, Junbo; Yang, Luyan; Zhou, Xiaoyuan; Wei, Xiao; Chen, Yunmin; Lu, Zhouguang; Ren, Fuzeng; Liu, Chain-Tsuan; Zhang, Ze; Han, Xiaodong
  作者单位：Beijing University of Technology; City University of Hong Kong; Chongqing University; Beijing Institute of Technology; Chinese Academy of Sciences; Institute of High Energy Physics, CAS; City University of Hong Kong; Zhejiang University; Northwestern Polytechnical University; Harbin Institute of Technology; Zhejiang University; Southern University of Science & Technology
  摘要：Body-centred cubic refractory multi-principal element alloys (MPEAs), with several refractory metal elements as constituents and featuring a yield strength greater than one gigapascal, are promising materials to meet the demands of aggressive structural applications1-6. Their low-to-no tensile ductility at room temperature, however, limits their processability and scaled-up application7-10. Here we present a HfNbTiVAl10 alloy that shows remarkable tensile ductility (roughly 20%) and ultrahigh ...
• Are we part of a unified work of absurd art? AI翻译
  作者：Shirlow, Ryan
• Predicting multiple conformations via sequence clustering and AlphaFold2 AI翻译
  作者：Wayment-Steele, Hannah K.; Ojoawo, Adedolapo; Otten, Renee; Apitz, Julia M.; Pitsawong, Warintra; Homberger, Marc; Ovchinnikov, Sergey; Colwell, Lucy; Kern, Dorothee
  作者单位：Brandeis University; Howard Hughes Medical Institute; Harvard University; Alphabet Inc.; Google Incorporated; University of Cambridge
  摘要：AlphaFold2 (ref. 1) has revolutionized structural biology by accurately predicting single structures of proteins. However, a protein's biological function often depends on multiple conformational substates2, and disease-causing point mutations often cause population changes within these substates3,4. We demonstrate that clustering a multiple-sequence alignment by sequence similarity enables AlphaFold2 to sample alternative states of known metamorphic proteins with high confidence. Using this m...