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作者：Loetzsch, R.; Beyer, H. F.; Duval, L.; Spillmann, U.; Banas, D.; Dergham, P.; Kroeger, F. M.; Glorius, J.; Grisenti, R. E.; Guerra, M.; Gumberidze, A.; Hess, R.; Hillenbrand, P. -m.; Indelicato, P.; Jagodzinski, P.; Lamour, E.; Lorentz, B.; Litvinov, S.; Litvinov, Yu. A.; Machado, J.; Paul, N.; Paulus, G. G.; Petridis, N.; Santos, J. P.; Scheidel, M.; Sidhu, R. S.; Steck, M.; Steydli, S.; Szary, K.; Trotsenko, S.; Uschmann, I.; Weber, G.; Stoehlker, Th.; Trassinelli, M.
作者单位：Friedrich Schiller University of Jena; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Universite PSL; College de France; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Jan Kochanowski University; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Universidade Nova de Lisboa; Justus Liebig University Giessen; Goethe University Frankfurt; University of Edinburgh
摘要：Quantum electrodynamics (QED), the quantum field theory that describes the interaction between light and matter, is commonly regarded as the best-tested quantum theory in modern physics. However, this claim is mostly based on extremely precise studies performed in the domain of relatively low field strengths and light atoms and ions1-6. In the realm of very strong electromagnetic fields such as in the heaviest highly charged ions (with nuclear charge Z >> 1), QED calculations enter a qualitati...
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作者：Sidik, Saima
摘要：The relatively low-cost drug simnotrelvir shortens symptoms for those with mild infections.
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作者：Kozlov, Max
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作者：Eisenstein, Michael
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作者：[Anonymous]
摘要：The world's urban environments face many problems. A new journal, Nature Cities, aims to bring together researchers who are rising to the challenge.
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作者：Borkar, Chandrashekhar D.; Stelly, Claire E.; Fu, Xin; Dorofeikova, Maria; Le, Quan-Son Eric; Vutukuri, Rithvik; Vo, Catherine; Walker, Alex; Basavanhalli, Samhita; Duong, Anh; Bean, Erin; Resendez, Alexis; Parker, Jones G.; Tasker, Jeffrey G.; Fadok, Jonathan P.
作者单位：Tulane University; Tulane University; Loyola University New Orleans; Tulane University; Northwestern University; Feinberg School of Medicine; Tulane University
摘要：Survival requires the selection of appropriate behaviour in response to threats, and dysregulated defensive reactions are associated with psychiatric illnesses such as post-traumatic stress and panic disorder1. Threat-induced behaviours, including freezing and flight, are controlled by neuronal circuits in the central amygdala (CeA)2; however, the source of neuronal excitation of the CeA that contributes to high-intensity defensive responses is unknown. Here we used a combination of neuroanato...
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作者：Schmidt, Ralf; Ward, Carl C.; Dajani, Rama; Armour-Garb, Zev; Ota, Mineto; Allain, Vincent; Hernandez, Rosmely; Layeghi, Madeline; Xing, Galen; Goudy, Laine; Dorovskyi, Dmytro; Wang, Charlotte; Chen, Yan Yi; Ye, Chun Jimmie; Shy, Brian R.; Gilbert, Luke A.; Eyquem, Justin; Pritchard, Jonathan K.; Dodgson, Stacie E.; Marson, Alexander
作者单位：Medical University of Vienna; Stanford University; University of California System; University of California San Francisco; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; University of California System; University of California Berkeley; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Stanford University; University of California System; University of California San Francisco; University of California System; University of California Berkeley
摘要：CRISPR-enabled screening is a powerful tool for the discovery of genes that control T cell function and has nominated candidate targets for immunotherapies1-6. However, new approaches are required to probe specific nucleotide sequences within key genes. Systematic mutagenesis in primary human T cells could reveal alleles that tune specific phenotypes. DNA base editors are powerful tools for introducing targeted mutations with high efficiency7,8. Here we develop a large-scale base-editing mutag...
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作者：Sepp, Mari; Leiss, Kevin; Murat, Florent; Okonechnikov, Konstantin; Joshi, Piyush; Leushkin, Evgeny; Spaenig, Lisa; Mbengue, Noe; Schneider, Celine; Schmidt, Julia; Trost, Nils; Schauer, Maria; Khaitovich, Philipp; Lisgo, Steven; Palkovits, Miklos; Giere, Peter; Kutscher, Lena M.; Anders, Simon; Cardoso-Moreira, Margarida; Sarropoulos, Ioannis; Pfister, Stefan M.; Kaessmann, Henrik
作者单位：Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); INRAE; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Leibniz Institut fur Evolutions und Biodiversitatsforschung; Chongqing Medical University; Newcastle University - UK; Semmelweis University; Ruprecht Karls University Heidelberg; Francis Crick Institute; Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; National Center for Tumor Diseases; Wellcome Trust Sanger Institute
摘要：The expansion of the neocortex, a hallmark of mammalian evolution1,2, was accompanied by an increase in cerebellar neuron numbers3. However, little is known about the evolution of the cellular programmes underlying the development of the cerebellum in mammals. In this study we generated single-nucleus RNA-sequencing data for around 400,000 cells to trace the development of the cerebellum from early neurogenesis to adulthood in human, mouse and the marsupial opossum. We established a consensus ...
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作者：Cao, Xiao-Yu
摘要：Mice that work out regularly have higher levels of a molecule that promotes muscle regeneration than sedentary mice do.
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作者：Couture, Victor
作者单位：University of British Columbia
