作者：Lee, Joo; Chen, Liang-Fu; Gaudin, Simon; Gupta, Kavvya; Novacic, Ana; Spakowitz, Andrew; Boettiger, Alistair Nicol
作者单位：Stanford University; Stanford University; Stanford University; Roche Holding; Roche Holding USA; Genentech
摘要：Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian chromosomes with self-mapping fluorescent labels and track them at ultraresolution. We find that sequences separated by submegabase distances transition to proximity in tens of seconds. This rapid search is dependent on cohesin and is exhibited only within domains. Domain borders act as kinetic imp...
作者：Li, Yuanjian; Kumar, Sonal; Yang, Gaoliang; Lu, Jun; Yao, Yan; Kang, Kisuk; Seh, Zhi Wei
作者单位：Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Materials Research & Engineering (IMRE); Zhejiang University; University of Houston System; University of Houston; University of Houston System; University of Houston; Seoul National University (SNU)
摘要：Monovalent (lithium, sodium, potassium) and multivalent (magnesium, calcium, aluminum) metal anodes are promising alternatives to graphite anodes for overcoming the performance limitations of lithium-ion batteries. In this Review, we compare and contrast their electrochemical behaviors in nonaqueous electrolytes by discussing their common challenges of irregular metal deposition and unstable solid electrolyte interphases (SEIs), as well as their differences, which are due to dissimilar surface...
