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作者:Frey, H. Christopher
作者单位:North Carolina State University
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作者:Feng, Xiaobo; Yin, Qiyu; Gao, Feng; Lu, Dan; Fang, Qin; Feng, Yilu; Huang, Xuchu; Tan, Chen; Zhou, Hanwen; Li, Qiang; Zhang, Chi; Stringer, Chris; Ni, Xijun
作者单位:Shanxi University; Hubei Polytechnic University; Hanjiang Normal University; Hanjiang Normal University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; China University of Geosciences; Natural History Museum London; Fudan University
摘要:Diverse forms of Homo coexisted during the Middle Pleistocene. Whether these fossil humans represent different species or clades is debated. The similar to 1-million-year-old Yunxian 2 fossil from China is important for understanding the cladogenesis of Homo and the origin of Homo sapiens. In this study, we restored and reconstructed the distorted Yunxian 2 cranium using recently introduced technology. The results show that this cranium displays mosaic primitive and derived features. Morphomet...
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作者:Holley, Elizabeth A.; Hadden, Karlie M.; Hammerling, Dorit; Eggert, Rod; Spiller, D. Erik; Nelson, Priscilla P.
作者单位:Colorado School of Mines; Colorado School of Mines; Colorado School of Mines; Colorado School of Mines
摘要:The United States (US) has sufficient geological endowment in active metal mines to reduce the nation's dependence on critical mineral imports. Demand is increasing for cobalt, nickel, rare earth elements, tellurium, germanium, and other materials used in energy production, semiconductors, and defense. This study uses a statistical evaluation of new geochemical datasets to quantify the critical minerals that are mined annually in US ores but go unrecovered. Ninety percent recovery of by-produc...
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作者:Cho, Adrian
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作者:Zhao, Celina
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作者:Wassarman, Douglas R.; Pfaff, Patrick; Paulo, Joao A.; Gygi, Steven P.; Shokat, Kevan M.; Kranzusch, Philip J.
作者单位:Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
摘要:7-Deazapurines are nucleobase analogs essential for nucleic acid modifications in nearly all cellular life. In this study, we discovered a role for 7-deazapurines in protein modification within type IV cyclic oligonucleotide-based antiviral signaling system (CBASS) antiphage defense and defined functions for CBASS ancillary proteins Cap9 and Cap10 in nucleobase-protein conjugation. A structure of Cap10 revealed a transfer RNA transglycosylase family enzyme remodeled to bind a partner cGAS/DncV...