6767期

最新文章

• Dual transposon sequencing profiles the genetic interaction landscape in bacteria AI翻译
  作者：Zik, Justin J.; Price, Morgan N.; Mayra, Keisha Hanifa Alma; Santoso, Audrey A.; Arkin, Adam P.; Deutschbauer, Adam M.; Sham, Lok-To
  作者单位：National University of Singapore; National University of Singapore; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform for assaying the fitness of a comprehensive double mutant pool in parallel. Dual Tn-seq couples random barcode transposon site sequencing with the Cre-lox system, enabling deep sampling of 73% of the 1.3 million possible double gene deletions in Streptococcus pneumoniae. The genetic interactions ...
• What to Expect When You're Dead: An Ancient Tour of Death and the Afterlife AI翻译
  作者：Riedl, Rachel Beatty
  作者单位：Cornell University
• 撤稿声明: In vivo direct imaging of neuronal activity at high temporospatial resolution AI翻译
  作者：Toi, Phan Tan; Jang, Hyun Jae; Min, Kyeongseon; Kim, Sung-Phil; Lee, Seung-Kyun; Lee, Jongho; Kwag, Jeehyun; Park, Jang-Yeon
  作者单位：Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Korea University; Baekseok University; Seoul National University (SNU); Ulsan National Institute of Science & Technology (UNIST); Seoul National University (SNU)
• Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity AI翻译
  作者：Wassarman, Douglas R.; Pfaff, Patrick; Paulo, Joao A.; Gygi, Steven P.; Shokat, Kevan M.; Kranzusch, Philip J.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of California System; University of California San Francisco; Howard Hughes Medical Institute; University of California System; University of California San Francisco; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute
  摘要：7-Deazapurines are nucleobase analogs essential for nucleic acid modifications in nearly all cellular life. In this study, we discovered a role for 7-deazapurines in protein modification within type IV cyclic oligonucleotide-based antiviral signaling system (CBASS) antiphage defense and defined functions for CBASS ancillary proteins Cap9 and Cap10 in nucleobase-protein conjugation. A structure of Cap10 revealed a transfer RNA transglycosylase family enzyme remodeled to bind a partner cGAS/DncV...
• Ethicists flirt with AI for reviewing human research AI翻译
  作者：Zhao, Celina
• Quantum learning advantage on a scalable photonic platform AI翻译
  作者：Liu, Zheng-Hao; Brunel, Romain; Ostergaard, Emil E. B.; Cordero, Oscar; Chen, Senrui; Wong, Yat; Nielsen, Jens A. H.; Bregnsbo, Axel B.; Zhou, Sisi; Huang, Hsin-Yuan; Oh, Changhun; Jiang, Liang; Preskill, John; Neergaard-Nielsen, Jonas S.; Andersen, Ulrik L.
  作者单位：Technical University of Denmark; University of Chicago; Perimeter Institute for Theoretical Physics; University of Waterloo; University of Waterloo; University of Waterloo; Alphabet Inc.; Google Incorporated; California Institute of Technology; Massachusetts Institute of Technology (MIT); Korea Advanced Institute of Science & Technology (KAIST)
  摘要：Recent advances in quantum technologies have demonstrated that quantum systems can outperform classical ones in specific tasks, a concept known as quantum advantage. Although previous efforts have focused on computational speedups, a definitive and provable quantum advantage that is unattainable by any classical system has remained elusive. In this work, we demonstrate a provable photonic quantum advantage by implementing a quantum-enhanced protocol for learning a high-dimensional physical pro...
• Hope, rediscovered AI翻译
  作者：White, Easton R.
  作者单位：University System Of New Hampshire; University of New Hampshire
• What if NIH had been 40% smaller? AI翻译
  作者：Azoulay, Pierre; Clancy, Matthew; Li, Danielle; Sampat, Bhaven N.
  作者单位：Massachusetts Institute of Technology (MIT); National Bureau of Economic Research; Johns Hopkins University; Johns Hopkins University
• An inheritance of long life AI翻译
  作者：Bohnert, K. Adam
  作者单位：Louisiana State University System; Louisiana State University
• Corporate tourism threatens protected areas AI翻译
  作者：O'Bryan, Christopher J.; Allan, James R.; Dapash, Meitamei Ole
  作者单位：Maastricht University