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作者：Riel, Bryan
作者单位：Zhejiang University
摘要：A deep-learning model infers large-scale dynamics of Antarctic ice shelves
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作者：Doran, Matthew H.; Niu, Qingwei; Zeng, Jianwei; Beneke, Tom; Smith, James; Ren, Peter; Fochler, Sophia; Coscia, Adrian; Hoeoeg, Johanna L.; Meleppattu, Shimi; Lishko, Polina V.; Wheeler, Richard J.; Gluenz, Eva; Zhang, Rui; Brown, Alan
作者单位：Harvard University; Harvard Medical School; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of Oxford; University of Bern; University of Gothenburg; University of Oxford; University of Edinburgh; University of Wurzburg; Harry Perkins Institute of Medical Research
摘要：The movement and pathogenicity of trypanosomatid species, the causative agents of trypanosomiasis and leishmaniasis, are dependent on a flagellum that contains an axoneme of dynein-bound doublet microtubules (DMTs). In this work, we present cryo-electron microscopy structures of DMTs from two trypanosomatid species, Leishmania tarentolae and Crithidia fasciculata, at resolutions up to 2.7 angstrom. The structures revealed 27 trypanosomatid-specific microtubule inner proteins, a specialized dyn...
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作者：Holmquist, Anna J.; Gillespie, Rosemary G.
作者单位：University of California System; University of California Berkeley
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作者：Jacobs, Phie
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作者：Stone, Richard
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作者：Chowdhury, Rituparno; Preuss, Marco D.; Cho, Hwan-Hee; Thompson, Joshua J. P.; Sen, Samarpita; Baikie, Tomi K.; Ghosh, Pratyush; Boeije, Yorrick; Chua, Xian Wei; Chang, Kai-Wei; Guo, Erjuan; van der Tol, Joost; van den Bersselaar, Bart W. L.; Taddeucci, Andrea; Daub, Nicolas; Dekker, Daphne M.; Keene, Scott T.; Vantomme, Ghislaine; Ehrler, Bruno; Meskers, Stefan C. J.; Rao, Akshay; Monserrat, Bartomeu; Meijer, E. W.; Friend, Richard H.
作者单位：University of Cambridge; Eindhoven University of Technology; Eindhoven University of Technology; University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; Huazhong University of Science & Technology; Diamond Light Source; University of Pisa; AMOLF; Yonsei University
摘要：Current organic light-emitting diode (OLED) technology uses light-emitting molecules in a molecular host. We report green circularly polarized luminescence (CPL) in a chirally ordered supramolecular assembly, with 24% dissymmetry in a triazatruxene (TAT) system. We found that TAT assembled into helices with a pitch of six molecules, associating angular momentum to the valence and conduction bands and obtaining the observed CPL. Cosublimation of TAT as the guest in a structurally mismatched hos...
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作者：de la Pompa, Jose Luis
作者单位：Centro Nacional de Investigaciones Cardiovasculares (CNIC); Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV
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作者：Reardon, Sara
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作者：Batra, Sahil; Allwein, Benjamin; Kumar, Charanya; Devbhandari, Sujan; Bruening, Jan-Gert; Bahng, Soon; Lee, Chong M.; Marians, Kenneth J.; Hite, Richard K.; Remus, Dirk
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
摘要：DNA G-quadruplexes (G4s) are non-B-form DNA secondary structures that threaten genome stability by impeding DNA replication. To elucidate how G4s induce replication fork arrest, we characterized fork collisions with preformed G4s in the parental DNA using reconstituted yeast and human replisomes. We demonstrate that a single G4 in the leading strand template is sufficient to stall replisomes by arresting the CMG helicase. Cryo-electron microscopy structures of stalled yeast and human CMG compl...
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作者：Brainard, Jeffrey
