2025

最新文章

• Heightened Scrutiny AI翻译
  作者：Thompson, Valerie; Kardon, Gabrielle; Shapiro, Michael D.; Koch, Paul L.; Krauss, Robert S.
  作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; University of California System; University of California Santa Cruz; Icahn School of Medicine at Mount Sinai
• Sunlight drives the abiotic formation of nitrous oxide in fresh and marine waters AI翻译
  作者：Leon-Palmero, Elizabeth; Morales-Baquero, Rafael; Thamdrup, Bo; Loscher, Carolin; Reche, Isabel
  作者单位：University of Granada; University of Southern Denmark; University of Granada; Princeton University
  摘要：Nitrous oxide (N2O) is a potent greenhouse gas and the main stratospheric ozone-depleting agent, yet its sources are not well resolved. In this work, we experimentally show a N2O production pathway not previously considered in greenhouse gas budgets, which we name photochemodenitrification. Sunlight induces substantial and consistent N2O production under oxic abiotic conditions in fresh and marine waters. We measured photochemical N2O production rates using isotope tracers and determined that ...
• Imperfect sounds AI翻译
  作者：O'Grady, Cathleen
• Studies seek signs of consciousness before birth AI翻译
  作者：Servick, Kelly
• Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms AI翻译
  作者：Xia, Xian; Shimogawa, Michelle M.; Wang, Hui; Liu, Samuel; Wijono, Angeline; Langousis, Gerasimos; Kassem, Ahmad M.; Wohlschlegel, James A.; Hill, Kent L.; Zhou, Z. Hong
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：The flagellum of Trypanosoma brucei drives the parasite's characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this process remain unclear. Here, we present high-resolution (up to 2.8 angstrom) cryo-electron microscopy structures of T. brucei flagellar doublet microtubules (DMTs). Integrated modeling identified 154 different axonemal proteins inside and outside the DMT and, together with genetic and proteomic i...
• Large AI models are cultural and social technologies AI翻译
  作者：Farrell, Henry; Gopnik, Alison; Shalizi, Cosma; Evans, James
  作者单位：Johns Hopkins University; Johns Hopkins University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; The Santa Fe Institute; Carnegie Mellon University; Carnegie Mellon University; University of Chicago
• Tunneling nanotube-like structures regulate distant cellular interactions during heart formation AI翻译
  作者：Miao, Lianjie; Lu, Yangyang; Nusrat, Anika; Fan, Guizhen; Zhang, Shaohua; Zhao, Luqi; Wu, Chia-Ling; Guo, Hongyan; Huyen, Trang Le Nu; Zheng, Yi; Fan, Zhen-Chuan; Shou, Weinian; Schwartz, Robert J.; Liu, Yu; Kumar, Ashok; Sui, Haixin; Serysheva, Irina I.; Burns, Alan R.; Wan, Leo Q.; Zhou, Bin; Evans, Sylvia M.; Wu, Mingfu
  作者单位：University of Houston System; University of Houston; University of Texas System; University of Texas Health Science Center Houston; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Center for Excellence in Molecular Cell Science, CAS; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Zhejiang University; Zhejiang University; Indiana University System; Indiana University Bloomington; University of Houston System; University of Houston; Wadsworth Center; State University of New York (SUNY) System; State University of New York (SUNY) System; University at Albany, SUNY; University of Houston System; University of Houston; Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; University of California System; University of California San Diego
  摘要：In the developing mammalian heart, the endocardium and the myocardium are separated by so-called cardiac jelly. Communication between the endocardium and the myocardium is essential for cardiac morphogenesis. How membrane-localized receptors and ligands achieve interaction across the cardiac jelly is not understood. Working in developing mouse cardiac morphogenesis models, we used a variety of cellular, imaging, and genetic approaches to elucidate this question. We found that myocardium and en...
• No sign that vaccine advisers are beholden to industry AI翻译
  作者：Wadman, Meredith
• Identification of antigen-presenting cell-T cell interactions driving immune responses to food AI翻译
  作者：Canesso, Maria Cecilia Campos; de Castro, Tiago Bruno Rezende; Nakandakari-Higa, Sandra; Lockhart, Ainsley; Luehr, Julia; Bortolatto, Juliana; Parsa, Roham; Esterhazy, Daria; Lyu, Mengze; Liu, Tian-Tian; Murphy, Kenneth M.; Sonnenberg, Gregory F.; Reis, Bernardo S.; Victora, Gabriel D.; Mucida, Daniel
  作者单位：Rockefeller University; Rockefeller University; University of Chicago; Cornell University; Weill Cornell Medicine; Washington University (WUSTL); Howard Hughes Medical Institute; Rockefeller University
  摘要：The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal antigens to CD4+ T cells and inducing their differentiation into regulatory (peripheral regulatory T cell) or inflammatory [T helper (Th) cell] subsets. We used a proximity labeling method (LIPSTIC) to identify APCs that presented dietary antigens under tolerizing and inflammatory conditions and to u...
• Face to face with the first known Western European AI翻译
  作者：Gibbons, Ann