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作者：Riggi, Nicolo; de Sousa e Melo, Felipe
作者单位：Roche Holding; Roche Holding USA; Genentech
摘要：Cells grown on a 3D scaffold have generated a 'mini-colon' that mimics key features of the organ. Controlled expression of cancer-associated genes in the system offers a way to examine tumour formation over space and time.
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作者：Seydel, Caroline
摘要：Latest methods bring the speed, portability, and long read lengths of nanopore sequencing to proteomics.
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作者：Hossain, Amer A.; Pigli, Ying Z.; Baca, Christian F.; Heissel, Soren; Thomas, Alexis; Libis, Vincent K.; Burian, Jan; Chappie, Joshua S.; Brady, Sean F.; Rice, Phoebe A.; Marraffini, Luciano A.
作者单位：Rockefeller University; University of Chicago; Rockefeller University; Rockefeller University; Cornell University; Rockefeller University; Howard Hughes Medical Institute
摘要：Bacteria have adapted to phage predation by evolving a vast assortment of defence systems(1). Although anti-phage immunity genes can be identified using bioinformatic tools, the discovery of novel systems is restricted to the available prokaryotic sequence data(2). Here, to overcome this limitation, we infected Escherichia coli carrying a soil metagenomic DNA library(3) with the lytic coliphage T4 to isolate clones carrying protective genes. Following this approach, we identified Brig1, a DNA ...
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作者：Abraham, Mary
摘要：Some fox species leap up and pounce head first into snow to capture prey that they hear below the surface. An analysis of the forces involved reveals how the shape of the skull has evolved to minimize damage from this behaviour.
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作者：Zuo, Hao; Park, Jinseo; Frangaj, Aurel; Ye, Jianxiang; Lu, Guanqi; Manning, Jamie J.; Asher, Wesley B.; Lu, Zhengyuan; Hu, Guo-bin; Wang, Liguo; Mendez, Joshua; Eng, Edward; Zhang, Zhening; Lin, Xin; Grassucci, Robert; Hendrickson, Wayne A.; Clarke, Oliver B.; Javitch, Jonathan A.; Conigrave, Arthur D.; Fan, Qing R.
作者单位：Columbia University; Columbia University; Columbia University; Columbia University; New York State Psychiatry Institute; United States Department of Energy (DOE); Brookhaven National Laboratory; Columbia University; Columbia University; Columbia University; University of Sydney; Columbia University
摘要：The human calcium-sensing receptor (CaSR) detects fluctuations in the extracellular Ca2+ concentration and maintains Ca2+ homeostasis(1,2). It also mediates diverse cellular processes not associated with Ca2+ balance(3-5). The functional pleiotropy of CaSR arises in part from its ability to signal through several G-protein subtypes(6). We determined structures of CaSR in complex with G proteins from three different subfamilies: G(q), G(i) and G(s). We found that the homodimeric CaSR of each co...
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作者：Conroy, Gemma
摘要：From extreme cold to strong magnets and high pressures, the Synergetic Extreme Condition User Facility (SECUF) provides conditions for researching potential wonder materials. Credit: Institute of Physics, Chinese Academy of SciencesAn aerial view of the Synergetic Extreme Condition User Facility.
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作者：Lebrat, Martin; Xu, Muqing; Kendrick, Lev Haldar; Kale, Anant; Gang, Youqi; Seetharaman, Pranav; Morera, Ivan; Khatami, Ehsan; Demler, Eugene; Greiner, Markus
作者单位：Harvard University; California State University System; San Jose State University; University of Barcelona; University of Barcelona; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：Quantum interference can deeply alter the nature of many-body phases of matter1. In the case of the Hubbard model, Nagaoka proved that introducing a single itinerant charge can transform a paramagnetic insulator into a ferromagnet through path interference2-4. However, a microscopic observation of this kinetic magnetism induced by individually imaged dopants has been so far elusive. Here we demonstrate the emergence of Nagaoka polarons in a Hubbard system realized with strongly interacting fer...
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作者：Rose, Michael; White, Henry S.
作者单位：University of Texas System; University of Texas Austin
摘要：Innovator who pioneered scanning electrochemical microscopy, bioassays and solar fuels.
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作者：Cassidy, Lara M.
作者单位：Trinity College Dublin
摘要：Genetic pedigrees spanning nine generations uncover the social organization of a nomadic empire that dominated much of central and eastern Europe from the sixth to the early ninth century.
