8011期

最新文章

• The Light Eaters: How the Unseen World of Plant Intelligence Offers a New Understanding of Life on Earth AI翻译
  作者：Montgomery, Beronda L.
• Ghost roads and the destruction of Asia-Pacific tropical forests AI翻译
  作者：Engert, Jayden E.; Campbell, Mason J.; Cinner, Joshua E.; Ishida, Yoko; Sloan, Sean; Supriatna, Jatna; Alamgir, Mohammed; Cislowski, Jaime; Laurance, William F.
  作者单位：James Cook University; James Cook University; James Cook University; University of Indonesia; University of Indonesia; University of Sydney; Vancouver Island University
  摘要：Roads are expanding at the fastest pace in human history. This is the case especially in biodiversity-rich tropical nations, where roads can result in forest loss and fragmentation, wildfires, illicit land invasions and negative societal effects 1-5 . Many roads are being constructed illegally or informally and do not appear on any existing road map 6-10 ; the toll of such 'ghost roads' on ecosystems is poorly understood. Here we use around 7,000 h of effort by trained volunteers to map ghost ...
• How rich is too rich? AI翻译
  作者：Chancel, Lucas
  作者单位：Harvard University; Institut d'Etudes Politiques Paris (Sciences Po); Paris School of Economics
  摘要：Where should society draw the line on extreme wealth? A fresh account sets out the logic and suggests how to redress inequality.
• Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers AI翻译
  作者：Ferretti, Stephane; Hamon, Jacques; de Kanter, Ruben; Scheufler, Clemens; Andraos-Rey, Rita; Barbe, Stephanie; Bechter, Elisabeth; Blank, Jutta; Bordas, Vincent; Dammassa, Ernesta; Decker, Andrea; Di Nanni, Noemi; Dourdoigne, Marion; Gavioli, Elena; Hattenberger, Marc; Heuser, Alisa; Hemmerlin, Christelle; Hinrichs, Juergen; Kerr, Grainne; Laborde, Laurent; Jaco, Isabel; Nunez, Eloisa Jimenez; Martus, Hans-Joerg; Quadt, Cornelia; Reschke, Markus; Romanet, Vincent; Schaeffer, Fanny; Schoepfer, Joseph; Schrapp, Maxime; Strang, Ross; Voshol, Hans; Wartmann, Markus; Welly, Sarah; Zecri, Frederic; Hofmann, Francesco; Moebitz, Henrik; Cortes-Cros, Marta
  作者单位：Novartis; Novartis; Novartis; Novartis USA
  摘要：The Werner syndrome RecQ helicase WRN was identified as a synthetic lethal target in cancer cells with microsatellite instability (MSI) by several genetic screens(1-6). Despite advances in treatment with immune checkpoint inhibitors(7-10), there is an unmet need in the treatment of MSI cancers(11-14). Here we report the structural, biochemical, cellular and pharmacological characterization of the clinical-stage WRN helicase inhibitor HRO761, which was identified through an innovative hit-findi...
• Growth of diamond in liquid metal at 1 atm pressure AI翻译
  作者：Gong, Yan; Luo, Da; Choe, Myeonggi; Kim, Yongchul; Ram, Babu; Zafari, Mohammad; Seong, Won Kyung; Bakharev, Pavel; Wang, Meihui; Park, In Kee; Lee, Seulyi; Shin, Tae Joo; Lee, Zonghoon; Lee, Geunsik; Ruoff, Rodney S.
  作者单位：Institute for Basic Science - Korea (IBS); Ulsan National Institute of Science & Technology (UNIST); Ulsan National Institute of Science & Technology (UNIST); Ulsan National Institute of Science & Technology (UNIST); Ulsan National Institute of Science & Technology (UNIST); Ulsan National Institute of Science & Technology (UNIST); Huazhong University of Science & Technology
  摘要：Natural diamonds were (and are) formed (thousands of million years ago) in the upper mantle of Earth in metallic melts at temperatures of 900-1,400 degrees C and at pressures of 5-6GPa (refs.(1,2)). Diamond is thermodynamically stable under high-pressure and high-temperature conditions as per the phase diagram of carbon(3). Scientists at General Electric invented and used a high-pressure and high-temperature apparatus in 1955 to synthesize diamonds by using molten iron sulfide at about 7GPa an...
• Control of working memory by phase-amplitude coupling of human hippocampal neurons AI翻译
  作者：Daume, Jonathan; Kaminski, Jan; Schjetnan, Andrea G. P.; Salimpour, Yousef; Khan, Umais; Kyzar, Michael; Reed, Chrystal M.; Anderson, William S.; Valiante, Taufik A.; Mamelak, Adam N.; Rutishauser, Ueli
  作者单位：Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Polish Academy of Sciences; Nencki Institute of Experimental Biology of the Polish Academy of Sciences; Krembil Research Institute; University of Toronto; University Health Network Toronto; University of Toronto; University Health Network Toronto; Johns Hopkins University; Johns Hopkins Medicine; California Institute of Technology
  摘要：Retaining information in working memory is a demanding process that relies on cognitive control to protect memoranda-specific persistent activity from interference(1,2). However, how cognitive control regulates working memory storage is unclear. Here we show that interactions of frontal control and hippocampal persistent activity are coordinated by theta-gamma phase-amplitude coupling (TG-PAC). We recorded single neurons in the human medial temporal and frontal lobe while patients maintained m...
• Japan can embrace open science - but flexible approaches are key AI翻译
  作者：Ide, Kazuki
  作者单位：University of Osaka
  摘要：Letter to the Editor
• I make 3D models of conifer needles to explore their climate effects AI翻译
  作者：Pisek, Jan
  作者单位：University of Tartu; Tartu Observatory
  摘要：Jan Pisek seeks a better understanding of how forests absorb sunlight, carbon and heat.
• What China's mission to collect rocks from the Moon's far side could reveal AI翻译
  作者：Xin, Ling
  摘要：The Chang'e-6 mission aims to land in the Moon's oldest and largest crater, where it will collect rocks to bring back to Earth.
• Reinvent oil refineries for a net-zero future AI翻译
  作者：[Anonymous]
  摘要：From petrol to plastics, oil-derived products define modern life. A bold plan to change that comes with huge costs - but researchers and policymakers should take it seriously.