8018期

最新文章

• Acceleration of radiative recombination for efficient perovskite LEDs (vol 630, pg 631, 2024) AI翻译
  作者：Li, Mengmeng; Yang, Yingguo; Kuang, Zhiyuan; Hao, Chenjie; Wang, Saixue; Lu, Feiyue; Liu, Zhongran; Liu, Jinglong; Zeng, Lingjiao; Cai, Yuxiao; Mao, Yulin; Guo, Jingshu; Tian, He; Xing, Guichuan; Cao, Yu; Ma, Chao; Wang, Nana; Peng, Qiming; Zhu, Lin; Huang, Wei; Wang, Jianpu
• Structural insights into the cross-exon to cross-intron spliceosome switch AI翻译
  作者：Zhang, Zhenwei; Kumar, Vinay; Dybkov, Olexandr; Will, Cindy L.; Zhong, Jiayun; Ludwig, Sebastian E. J.; Urlaub, Henning; Kastner, Berthold; Stark, Holger; Luehrmann, Reinhard
  作者单位：Sichuan University; Sichuan University; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL
  摘要：Early spliceosome assembly can occur through an intron-defined pathway, whereby U1 and U2 small nuclear ribonucleoprotein particles (snRNPs) assemble across the intron(1). Alternatively, it can occur through an exon-defined pathway(2-5), whereby U2 binds the branch site located upstream of the defined exon and U1 snRNP interacts with the 5 ' splice site located directly downstream of it. The U4/U6.U5 tri-snRNP subsequently binds to produce a cross-intron (CI) or cross-exon (CE) pre-B complex, ...
• Translation tool embraces overlooked languages AI翻译
  作者：Adelani, David I.
  作者单位：University of London; University College London; McGill University; Mila Quebec Artificial Intelligence Institute
• How climate change is harming health in Europe AI翻译
  作者：Wong, Carissa
• Sleep loss diminishes hippocampal reactivation and replay AI翻译
  作者：Giri, Bapun; Kinsky, Nathaniel; Kaya, Utku; Maboudi, Kourosh; Abel, Ted; Diba, Kamran
  作者单位：University of Michigan System; University of Michigan; University of Wisconsin System; University of Wisconsin Milwaukee; University of Iowa; University of Michigan System; University of Michigan
  摘要：Memories benefit from sleep(1), and the reactivation and replay of waking experiences during hippocampal sharp-wave ripples (SWRs) are considered to be crucial for this process(2). However, little is known about how these patterns are impacted by sleep loss. Here we recorded CA1 neuronal activity over 12 h in rats across maze exploration, sleep and sleep deprivation, followed by recovery sleep. We found that SWRs showed sustained or higher rates during sleep deprivation but with lower power an...
• AI translators need cultural competence AI翻译
  作者：Tenzer, Helene; Feuerriegel, Stefan; Piekkari, Rebecca
  作者单位：University of Munich; Aalto University
• Two decades of deep ice cores from Antarctica AI翻译
  作者：Kawamura, Kenji; Oyabu, Ikumi
  作者单位：Research Organization of Information & Systems (ROIS); National Institute of Polar Research (NIPR) - Japan
  摘要：In June 2004, the results of an ambitious Antarctic ice-drilling project brought insight into hundreds of thousands of years of climatic changes. The extraordinary sample still has much to offer climate research - even as its successor is being drilled.
• Plasmid targeting and destruction by the DdmDE bacterial defence system AI翻译
  作者：Bravo, Jack P. K.; Ramos, Delisa A.; Fregoso Ocampo, Rodrigo; Ingram, Caiden; Taylor, David W.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Institute of Science & Technology - Austria
  摘要：Although eukaryotic Argonautes have a pivotal role in post-transcriptional gene regulation through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on auxiliary nuclease factors for efficient foreign DNA degradation1. Here we reveal the activation pathway of the DNA defence module DdmDE system, which rapidly eliminates small, multicopy plasmids from the Vibrio cholerae seventh pandemic strain (7PET)2. Through a combination of cryo-electron microscopy, biochemistry ...
• See how your body works in real time - wearable ultrasound is on its way AI翻译
  作者：Wang, Chonghe; Zhao, Xuanhe
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：Full-body, continuous wearable ultrasound will benefit health care and biomedical research. Seven key obstacles must first be overcome.
• Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines AI翻译
  作者：Liang, Chieh-Yu; Raju, Saravanan; Liu, Zhuoming; Li, Yuhao; Arunkumar, Guha Asthagiri; Case, James Brett; Scheaffer, Suzanne M.; Zost, Seth J.; Acreman, Cory M.; Gagne, Matthew; Andrew, Shayne F.; dos Anjos, Deborah Carolina Carvalho; Foulds, Kathryn E.; McLellan, Jason S.; Crowe Jr, James E.; Douek, Daniel C.; Whelan, Sean P. J.; Elbashir, Sayda M.; Edwards, Darin K.; Diamond, Michael S.
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Vanderbilt University; Vanderbilt University; University of Texas System; University of Texas Austin; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Vanderbilt University; Washington University (WUSTL); Washington University (WUSTL)
  摘要：Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination1,2. The effects of immune imprinting on serum antibody responses after boosting with variant-matched SARS-CoV-2 vaccines remain uncertain. Here we characterized the serum antibody responses after mRNA vaccine boosting of mice and human clinical trial participants. In mice, a single dose of a preclinical version of mRNA-1273 vaccine encoding Wuhan-1 spike protein min...