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作者：[Anonymous]
摘要：Should one principal investigator have the power to determine postdocs' careers? Share your thoughts on academia's dominant funding model in our survey and reader poll.
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作者：Ahmed, Anees; Joseph, Ann M.; Zhou, Jordan; Horn, Veronika; Uddin, Jazib; Lyu, Mengze; Goc, Jeremy; Sockolow, Robbyn E.; Wing, James B.; Vivier, Eric; Sakaguchi, Shimon; Sonnenberg, Gregory F.
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of Osaka; University of Osaka; University of Osaka; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille; Kyoto University
摘要：Interleukin (IL-)23 is a major mediator and therapeutic target in chronic inflammatory diseases that also elicits tissue protection in the intestine at homeostasis or following acute infection(1-4). However, the mechanisms that shape these beneficial versus pathological outcomes remain poorly understood. To address this gap in knowledge, we performed single-cell RNA sequencing on all IL-23 receptor-expressing cells in the intestine and their acute response to IL-23, revealing a dominance of T ...
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作者：Bader, Jackie E.; Wolf, Melissa M.; Lupica-Tondo, Gian Luca; Madden, Matthew Z.; Reinfeld, Bradley I.; Arner, Emily N.; Hathaway, Emma S.; Steiner, KayLee K.; Needle, Gabriel A.; Hatem, Zaid; Landis, Madelyn D.; Faneuff, Eden E.; Blackman, Amondrea; Wolf, Elysa M.; Cottam, Matthew A.; Ye, Xiang; Bates, Madison E.; Smart, Kyra; Wang, Wenjun; Pinheiro, Laura V.; Christofides, Anthos; Smith, DuPreez; Boussiotis, Vassiliki A.; Haake, Scott M.; Beckermann, Kathryn E.; Wellen, Kathryn E.; Reinhart-King, Cynthia A.; Serezani, C. Henrique; Lee, Cheng-Han; Aubrey, Christa; Chen, Heidi; Rathmell, W. Kimryn; Hasty, Alyssa H.; Rathmell, Jeffrey C.
作者单位：Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; University of Pennsylvania; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of Alberta; Vanderbilt University; University of Pennsylvania; University of Alberta; Vanderbilt University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Tennessee Valley Healthcare System
摘要：Obesity is a leading risk factor for progression and metastasis of many cancers(1,2), yet can in some cases enhance survival(3-5) and responses to immune checkpoint blockade therapies, including anti-PD-1, which targets PD-1 (encoded by PDCD1), an inhibitory receptor expressed on immune cells6-8. Although obesity promotes chronic inflammation, the role of the immune system in the obesity-cancer connection and immunotherapy remains unclear. It has been shown that in addition to T cells, macroph...
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作者：[Anonymous]
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作者：Zavitsanou, Anastasia-Maria; Abdus-Saboor, Ishmail
作者单位：Columbia University; Columbia University; Howard Hughes Medical Institute
摘要：A little-studied sensory structure called the Krause corpuscle is responsible for detecting light touch and is essential for normal sexual behaviour in mice. The findings have interesting implications for human sexual intimacy.
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作者：Lu, Jun; Wu, Wenbing; Colombari, Felippe Mariano; Jawaid, Ali; Seymour, Bryan; Whisnant, Kody; Zhong, Xiaoyang; Choi, Wonjin; Chalmpes, Nikolaos; Lahann, Joerg; Vaia, Richard A.; de Moura, Andre Farias; Nepal, Dhriti; Kotov, Nicholas A.
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; United States Department of Defense; United States Air Force; US Air Force Research Laboratory; UES, Inc.; ARCTOS; Cornell University; Universidade Federal de Sao Carlos; University of Michigan System; University of Michigan
摘要：Composites from 2D nanomaterials show uniquely high electrical, thermal and mechanical properties1,2. Pairing their robustness with polarization rotation is needed for hyperspectral optics in extreme conditions3,4. However, the rigid nanoplatelets have randomized achiral shapes, which scramble the circular polarization of photons with comparable wavelengths. Here we show that multilayer nanocomposites from 2D nanomaterials with complex textured surfaces strongly and controllably rotate light p...
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作者：[Anonymous]
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作者：Benjamin, Katherine; Bhandari, Aneesha; Kepple, Jessica D.; Qi, Rui; Shang, Zhouchun; Xing, Yanan; An, Yanru; Zhang, Nannan; Hou, Yong; Crockford, Tanya L.; McCallion, Oliver; Issa, Fadi; Hester, Joanna; Tillmann, Ulrike; Harrington, Heather A.; Bull, Katherine R.
作者单位：University of Oxford; University of Oxford; Wellcome Centre for Human Genetics; University of Oxford; University of Oxford; Chinese Academy of Medical Sciences - Peking Union Medical College; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Oxford; University of Cambridge; Max Planck Society; Technische Universitat Dresden
摘要：Spatial transcriptomics measures in situ gene expression at millions of locations within a tissue(1), hitherto with some trade-off between transcriptome depth, spatial resolution and sample size(2). Although integration of image-based segmentation has enabled impactful work in this context, it is limited by imaging quality and tissue heterogeneity. By contrast, recent array-based technologies offer the ability to measure the entire transcriptome at subcellular resolution across large samples(3...
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作者：Adam, David
摘要：Rampant deepfakes and false news are often blamed for swaying votes. Research suggests it's hard to change people's political opinions, but easier to nudge their behaviour.
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作者：Wang, Dashun
作者单位：Northwestern University; Northwestern University; Northwestern University
摘要：Artificial-intelligence algorithms could identify scientists who need support with translating their work into real-world applications and more. Leaders must step up.
