8019期

最新文章

• A deconstruction-reconstruction strategy for pyrimidine diversification AI翻译
  作者：Uhlenbruck, Benjamin J. H.; Josephitis, Celena M.; de Lescure, Louis; Paton, Robert S.; McNally, Andrew
  作者单位：Colorado State University System; Colorado State University Fort Collins
  摘要：Structure-activity relationship (SAR) studies are fundamental to drug and agrochemical development, yet only a few synthetic strategies apply to the nitrogen heteroaromatics frequently encountered in small molecule candidates(1-3). Here we present an alternative approach in which we convert pyrimidine-containing compounds into various other nitrogen heteroaromatics. Transforming pyrimidines into their corresponding N-arylpyrimidinium salts enables cleavage into a three-carbon iminoenamine buil...
• Zinc mediates control of nitrogen fixation via transcription factor filamentation AI翻译
  作者：Lin, Jieshun; Bjork, Peter K.; Kolte, Marie V.; Poulsen, Emil; Dedic, Emil; Drace, Taner; Andersen, Stig U.; Nadzieja, Marcin; Liu, Huijun; Castillo-Michel, Hiram; Escudero, Viviana; Gonzalez-Guerrero, Manuel; Boesen, Thomas; Pedersen, Jan Skov; Stougaard, Jens; Andersen, Kasper R.; Reid, Dugald
  作者单位：Aarhus University; Aarhus University; European Synchrotron Radiation Facility (ESRF); Universidad Politecnica de Madrid; Universidad Politecnica de Madrid; Aarhus University; La Trobe University; La Trobe University
  摘要：Plants adapt to fluctuating environmental conditions by adjusting their metabolism and gene expression to maintain fitness1. In legumes, nitrogen homeostasis is maintained by balancing nitrogen acquired from soil resources with nitrogen fixation by symbiotic bacteria in root nodules2-8. Here we show that zinc, an essential plant micronutrient, acts as an intracellular second messenger that connects environmental changes to transcription factor control of metabolic activity in root nodules. We ...
• AGE CAP: PROTEIN GIVES ELDERLY MICE NEW LEASE OF LIFE AI翻译
  作者：[Anonymous]
• BIOBANK RETURNS GENOME DATA TO ONE-FIFTH OF ESTONIANS AI翻译
  作者：Callaway, Ewen
• Hearing How fish sense the direction of sound AI翻译
  作者：Carr, Catherine E.
  作者单位：University System of Maryland; University of Maryland College Park
  摘要：Scientists have long sought to explain how fish can sense the direction of sound, given the challenges that hearing underwater poses. An experimental study testing a variety of models now provides some answers. See p.118
• Canadian housing crisis demands local leadership AI翻译
  作者：Christensen, Julia
  作者单位：Queens University - Canada
• Where I work N. M. Ganesh Babu AI翻译
  作者：Nogrady, Bianca; Babu, N. M. Ganesh
• Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing (vol 586, pg 113, 2020) AI翻译
  作者：Riva, Laura; Yuan, Shuofeng; Yin, Xin; Martin-Sancho, Laura; Matsunaga, Naoko; Pache, Lars; Burgstaller-Muehlbacher, Sebastian; De Jesus, Paul D.; Teriete, Peter; Hull, Mitchell V.; Chang, Max W.; Chan, Jasper Fuk-Woo; Cao, Jianli; Poon, Vincent Kwok-Man; Herbert, Kristina M.; Cheng, Kuoyuan; Nguyen, Tu-Trinh H.; Rubanov, Andrey; Pu, Yuan; Nguyen, Courtney; Choi, Angela; Rathnasinghe, Raveen; Schotsaert, Michael; Miorin, Lisa; Dejosez, Marion; Zwaka, Thomas P.; Sit, Ko-Yung; Martinez-Sobrido, Luis; Liu, Wen-Chun; White, Kris M.; Chapman, Mackenzie E.; Lendy, Emma K.; Glynne, Richard J.; Albrecht, Randy; Ruppin, Eytan; Mesecar, Andrew D.; Johnson, Jeffrey R.; Benner, Christopher; Sun, Ren; Schultz, Peter G.; Su, Andrew I.; Garcia-Sastre, Adolfo; Chatterjee, Arnab K.; Yuen, Kwok-Yung; Chanda, Sumit K.
• Brain Chimeroids reveal individual susceptibility to neurotoxic triggers AI翻译
  作者：Anton-Bolanos, Noelia; Faravelli, Irene; Faits, Tyler; Andreadis, Sophia; Kastli, Rahel; Trattaro, Sebastiano; Adiconis, Xian; Wei, Anqi; Sampath Kumar, Abhishek; Di Bella, Daniela J.; Tegtmeyer, Matthew; Nehme, Ralda; Levin, Joshua Z.; Regev, Aviv; Arlotta, Paola
  作者单位：Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Roche Holding; Roche Holding USA; Genentech
  摘要：Interindividual genetic variation affects the susceptibility to and progression of many diseases1,2. However, efforts to study how individual human brains differ in normal development and disease phenotypes are limited by the paucity of faithful cellular human models, and the difficulty of scaling current systems to represent multiple people. Here we present human brain Chimeroids, a highly reproducible, multidonor human brain cortical organoid model generated by the co-development of cells fr...
• Amazon forest biogeography predicts resilience and vulnerability to drought AI翻译
  作者：Chen, Shuli; Stark, Scott C.; Nobre, Antonio Donato; Cuartas, Luz Adriana; de Jesus Amore, Diogo; Restrepo-Coupe, Natalia; Smith, Marielle N.; Chitra-Tarak, Rutuja; Ko, Hongseok; Nelson, Bruce W.; Saleska, Scott R.
  作者单位：University of Arizona; Michigan State University; Instituto Nacional de Pesquisas Espaciais (INPE); Bangor University; United States Department of Energy (DOE); Los Alamos National Laboratory; Institute Nacional de Pesquisas da Amazonia; University of Arizona
  摘要：Amazonia contains the most extensive tropical forests on Earth, but Amazon carbon sinks of atmospheric CO2 are declining, as deforestation and climate-change-associated droughts1-4 threaten to push these forests past a tipping point towards collapse5-8. Forests exhibit complex drought responses, indicating both resilience (photosynthetic greening) and vulnerability (browning and tree mortality), that are difficult to explain by climate variation alone9-17. Here we combine remotely sensed photo...