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作者：Duttke, Sascha H.; Guzman, Carlos; Chang, Max; Delos Santos, Nathaniel P.; McDonald, Bayley R.; Xie, Jialei; Carlin, Aaron F.; Heinz, Sven; Benner, Christopher
作者单位：Washington State University; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：Patterns of transcriptional activity are encoded in our genome through regulatory elements such as promoters or enhancers that, paradoxically, contain similar assortments of sequence-specific transcription factor (TF) binding sites(1-3). Knowledge of how these sequence motifs encode multiple, often overlapping, gene expression programs is central to understanding gene regulation and how mutations in non-coding DNA manifest in disease(4,5). Here, by studying gene regulation from the perspective...
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作者：Ro, Christine
摘要：Nature sent a reporter to find out as part of an investigation into dud events.
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作者：Bernaschi, Massimo; Gonzalez-Adalid Pemartin, Isidoro; Martin-Mayor, Victor; Parisi, Giorgio
作者单位：Consiglio Nazionale delle Ricerche (CNR); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - UAM - Institut de Fisica Teorica (IFT); Complutense University of Madrid; Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR)
摘要：Quantum annealers are commercial devices that aim to solve very hard computational problems(1), typically those involving spin glasses(2,3). Just as in metallurgic annealing, in which a ferrous metal is slowly cooled(4), quantum annealers seek good solutions by slowly removing the transverse magnetic field at the lowest possible temperature. Removing the field diminishes the quantum fluctuations but forces the system to traverse the critical point that separates the disordered phase (at large ...
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作者：Nowogrodzki, Julian
摘要：Companies are using artificial intelligence tools to help scientists to query their data without the need for programming skills.
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作者：Hoer, Jens; Wolf, Sharon G.; Sorek, Rotem
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Helmholtz Association; Helmholtz-Center for Infection Research
摘要：Several immune pathways in humans conjugate ubiquitin-like proteins to virus and host molecules as a means of antiviral defence(1-5). Here we studied an antiphage defence system in bacteria, comprising a ubiquitin-like protein, ubiquitin-conjugating enzymes E1 and E2, and a deubiquitinase. We show that during phage infection, this system specifically conjugates the ubiquitin-like protein to the phage central tail fibre, a protein at the tip of the tail that is essential for tail assembly as we...
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作者：Ledford, Heidi
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作者：Walchli, Thomas
作者单位：University of Toronto; University Health Network Toronto; Krembil Research Institute; University of Toronto
摘要：The brain vasculature is important for the developing and mature human brain, and it plays crucial parts in several brain pathologies. Single-cell RNA sequencing enabled the construction of a single-cell atlas of the fetal, adult healthy and adult diseased human brain vasculature, uncovering its molecular architecture and heterogeneity, and capturing reactivated fetal programs as well as conserved properties in the diseased vascular endothelium.
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作者：Gauci, Vincent; Pangala, Sunitha Rao; Shenkin, Alexander; Barba, Josep; Bastviken, David; Figueiredo, Viviane; Gomez, Carla; Enrich-Prast, Alex; Sayer, Emma; Stauffer, Taina; Welch, Bertie; Elias, Dafydd; McNamara, Niall; Allen, Myles; Malhi, Yadvinder
作者单位：University of Birmingham; University of Birmingham; Lancaster University; Northern Arizona University; Centro de Investigacion Ecologica y Aplicaciones Forestales (CREAF-CERCA); Linkoping University; Open University - UK; Universidade Federal do Rio de Janeiro; Universidade Federal de Sao Paulo (UNIFESP); Smithsonian Institution; Smithsonian Tropical Research Institute; Ulm University; Lancaster University; UK Centre for Ecology & Hydrology (UKCEH); University of Oxford; University of Oxford; University of Oxford
摘要：Methane is an important greenhouse gas1, but the role of trees in the methane budget remains uncertain2. Although it has been shown that wetland and some upland trees can emit soil-derived methane at the stem base3,4, it has also been suggested that upland trees can serve as a net sink for atmospheric methane5,6. Here we examine in situ woody surface methane exchange of upland tropical, temperate and boreal forest trees. We find that methane uptake on woody surfaces, in particular at and above...
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作者：Yoon, Yoseob; Lu, Zheyu; Uzundal, Can; Qi, Ruishi; Zhao, Wenyu; Chen, Sudi; Feng, Qixin; Kim, Woochang; Naik, Mit H.; Watanabe, Kenji; Taniguchi, Takashi; Louie, Steven G.; Crommie, Michael F.; Wang, Feng
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Northeastern University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; National Institute for Materials Science; National Institute for Materials Science
摘要：Phonon engineering at gigahertz frequencies forms the foundation of microwave acoustic filters1, acousto-optic modulators2 and quantum transducers3,4. Terahertz phonon engineering could lead to acoustic filters and modulators at higher bandwidth and speed, as well as quantum circuits operating at higher temperatures. Despite their potential, methods for engineering terahertz phonons have been limited due to the challenges of achieving the required material control at subnanometre precision and...
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作者：[Anonymous]
