High-resolution atlas of the developing, adult and diseased human brain vasculature
成果类型：
Editorial Material
署名作者：
Walchli, Thomas
署名单位：
University of Toronto; University Health Network Toronto; Krembil Research Institute; University of Toronto
刊物名称：
Nature
ISSN/ISSBN：
0028-4813
DOI：
10.1038/d41586-024-02284-x
发表日期：
2024-07-25
页码：
E17-E17
关键词：
摘要：
The brain vasculature is important for the developing and mature human brain, and it plays crucial parts in several brain pathologies. Single-cell RNA sequencing enabled the construction of a single-cell atlas of the fetal, adult healthy and adult diseased human brain vasculature, uncovering its molecular architecture and heterogeneity, and capturing reactivated fetal programs as well as conserved properties in the diseased vascular endothelium.