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作者：Mattick, John
作者单位：University of New South Wales Sydney
摘要：An insider's story of the discoveries that revealed the dazzling abilities of RNA, and the therapeutic possibilities that emerged.
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作者：Borrelli, Costanza; Roberts, Morgan; Eletto, Davide; Hussherr, Marie-Didiee; Fazilaty, Hassan; Valenta, Tomas; Lafzi, Atefeh; Kretz, Jonas A.; Vinzoni, Elena Guido; Karakatsani, Andromachi; Adivarahan, Srivathsan; Mannhart, Ardian; Kimura, Shoichiro; Meijs, Ab; Mhamedi, Farah Baccouche; Acar, Ilhan E.; Handler, Kristina; Ficht, Xenia; Platt, Randall J.; Piscuoglio, Salvatore; Moor, Andreas E.
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; Czech Academy of Sciences; Institute of Molecular Genetics of the Czech Academy of Sciences; University of Basel
摘要：It is estimated that only 0.02% of disseminated tumour cells are able to seed overt metastases1. While this suggests the presence of environmental constraints to metastatic seeding, the landscape of host factors controlling this process remains largely unclear. Here, combining transposon technology2 and fluorescence niche labelling3, we developed an in vivo CRISPR activation screen to systematically investigate the interactions between hepatocytes and metastatic cells. We identify plexin B2 as...
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作者：Zhao, Ke; Liu, Qingqing; Yao, Libing; Deger, Caner; Shen, Jiahui; Zhang, Xu; Shi, Pengju; Tian, Yuan; Luo, Yixin; Xu, Jiazhe; Zhou, Jingjing; Jin, Donger; Wang, Sisi; Fan, Wei; Zhang, Shaochen; Chu, Shenglong; Wang, Xiaonan; Tian, Liuwen; Liu, Ruzhang; Zhang, Li; Yavuz, Ilhan; Wang, Hong-fei; Yang, Deren; Wang, Rui; Xue, Jingjing
作者单位：Zhejiang University; Zhejiang University; Westlake University; Westlake University; Marmara University; Yangzhou University; Westlake University; Baima Lake Laboratory; Westlake University; Westlake University; Westlake University
摘要：Molecule-based selective contacts have become a crucial component to ensure high-efficiency inverted perovskite solar cells1-5. These molecules always consist of a conjugated core with heteroatom substitution to render the desirable carrier-transport capability6-9. So far, the design of successful conjugation cores has been limited to two N-substituted pi-conjugated structures, carbazole and triphenylamine, with molecular optimization evolving around their derivatives2,5,10-12. However, furthe...
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作者：Henley, Benjamin J.; McGregor, Helen V.; King, Andrew D.; Hoegh-Guldberg, Ove; Arzey, Ariella K.; Karoly, David J.; Lough, Janice M.; DeCarlo, Thomas M.; Linsley, Braddock K.
作者单位：University of Wollongong; University of Wollongong; University of Melbourne; University of Melbourne; University of Melbourne; University of Queensland; Australian Institute of Marine Science; University of Western Australia; University of Western Australia; Tulane University; Columbia University
摘要：Mass coral bleaching on the Great Barrier Reef (GBR) in Australia between 2016 and 2024 was driven by high sea surface temperatures (SST)1. The likelihood of temperature-induced bleaching is a key determinant for the future threat status of the GBR2, but the long-term context of recent temperatures in the region is unclear. Here we show that the January-March Coral Sea heat extremes in 2024, 2017 and 2020 (in order of descending mean SST anomalies) were the warmest in 400 years, exceeding the ...
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作者：Mallapaty, Smriti
摘要：A man in Germany is HIV-free after receiving stem cells that are not resistant to the virus.
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作者：Nakatsuka, Nathan; Holguin, Brian; Sedig, Jakob; Langenwalter, Paul E.; Carpenter, John; Culleton, Brendan J.; Garcia-Moreno, Cristina; Harper, Thomas K.; Martin, Debra; Martinez-Ramirez, Jupiter; Porcayo-Michelini, Antonio; Tiesler, Vera; Villapando-Canchola, M. Elisa; Valdes Herrera, Alejandro; Callan, Kim; Curtis, Elizabeth; Kearns, Aisling; Iliev, Lora; Lawson, Ann Marie; Mah, Matthew; Mallick, Swapan; Micco, Adam; Michel, Megan; Workman, J. Noah; Oppenheimer, Jonas; Qiu, Lijun; Zalzala, Fatma; Rohland, Nadin; Diaz, Jose Luis Punzo; Johnson, John R.; Reich, David
作者单位：Harvard University; Harvard Medical School; Harvard University; University of California System; University of California Santa Barbara; Harvard University; Biola University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; Universidad Autonoma de Yucatan; Howard Hughes Medical Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
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作者：Palmer, Nicholas J.; Barrie, Kyle R.; Dominguez, Roberto
作者单位：University of Pennsylvania; University of Pennsylvania
摘要：Humans express 15 formins that play crucial roles in actin-based processes, including cytokinesis, cell motility and mechanotransduction1,2. However, the lack of structures bound to the actin filament (F-actin) has been a major impediment to understanding formin function. Whereas formins are known for their ability to nucleate and elongate F-actin3-7, some formins can additionally depolymerize, sever or bundle F-actin. Two mammalian formins, inverted formin 2 (INF2) and diaphanous 1 (DIA1, enc...
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作者：Liu, Zhihui; Sun, Wenfei; Ng, Yi Han; Dong, Hua; Quake, Stephen R.; Sudhof, Thomas C.
作者单位：Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：Social communication guides decision-making, which is essential for survival. Social transmission of food preference (STFP) is an ecologically relevant memory paradigm in which an animal learns a desirable food odour from another animal in a social context, creating a long-term memory(1,2). How food-preference memory is acquired, consolidated and stored is unclear. Here we show that the posteromedial nucleus of the cortical amygdala (COApm) serves as a computational centre in long-term STFP me...
