8024期

最新文章

• Normal liver cells unlock cancer spread AI翻译
  作者：Woess, Katharina; Alonso-Curbelo, Direna
• Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants AI翻译
  作者：Kim, Elizabeth D.; Wu, Xiaoan; Lee, Sangyun; Tibbs, Gareth R.; Cunningham, Kevin P.; Di Zanni, Eleonora; Perez, Marta E.; Goldstein, Peter A.; Accardi, Alessio; Larsson, H. Peter; Nimigean, Crina M.
  作者单位：Cornell University; Weill Cornell Medicine; University of Miami; University of Westminster; Cornell University; Weill Cornell Medicine; Linkoping University
  摘要：Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels1 are essential for pacemaking activity and neural signalling2,3. Drugs inhibiting HCN1 are promising candidates for management of neuropathic pain4 and epileptic seizures5. The general anaesthetic propofol (2,6-di-iso-propylphenol) is a known HCN1 allosteric inhibitor(6) with unknown structural basis. Here, using single-particle cryo-electron microscopy and electrophysiology, we show that propofol inhibits HCN1 by binding to a ...
• Human TMEFF1 is a restriction factor for herpes simplex virus in the brain AI翻译
  作者：Chan, Yi-Hao; Liu, Zhiyong; Bastard, Paul; Khobrekar, Noopur; Hutchison, Kennen M.; Yamazaki, Yasuhiro; Fan, Qing; Matuozzo, Daniela; Harschnitz, Oliver; Kerrouche, Nacim; Nakajima, Koji; Amin, Param; Yatim, Ahmad; Rinchai, Darawan; Chen, Jie; Zhang, Peng; Ciceri, Gabriele; Chen, Jia; Dobbs, Kerry; Belkaya, Serkan; Lee, Danyel; Gervais, Adrian; Aydin, Kursad; Kartal, Ayse; Hasek, Mary L.; Zhao, Shuxiang; Reino, Eduardo Garcia; Lee, Yoon Seung; Seeleuthner, Yoann; Chaldeba, Matthieu; Bailey, Rasheed; Vanhulle, Catherine; Lorenzo, Lazaro; Boucherit, Soraya; Rozenberg, Flore; Marr, Nico; Mogensen, Trine H.; Aubart, Melodie; Cobat, Aurelie; Dulac, Olivier; Emiroglu, Melike; Paludan, Soren R.; Abel, Laurent; Notarangelo, Luigi; Longnecker, Richard; Smith, Greg; Studer, Lorenz; Casanova, Jean-Laurent; Zhang, Shen-Ying
  作者单位：Rockefeller University; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Northwestern University; Feinberg School of Medicine; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Human Technopole; Ihsan Dogramaci Bilkent University; Istanbul Medipol University; Selcuk University; Universite de Rouen Normandie; CHU de Rouen; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Cochin - APHP; Sidra Medical & Research Center; Aarhus University; Aarhus University; Aarhus University; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Selcuk University; University of Gothenburg; Howard Hughes Medical Institute
  摘要：Most cases of herpes simplex virus 1 (HSV-1) encephalitis (HSE) remain unexplained(1,2). Here, we report on two unrelated people who had HSE as children and are homozygous for rare deleterious variants of TMEFF1, which encodes a cell membrane protein that is preferentially expressed by brain cortical neurons. TMEFF1 interacts with the cell-surface HSV-1 receptor NECTIN-1, impairing HSV-1 glycoprotein D- and NECTIN-1-mediated fusion of the virus and the cell membrane, blocking viral entry. Gene...
• From Vikings to Beethoven: what your DNA says about your ancient relatives AI翻译
  作者：Callaway, Ewen
  摘要：Scientists are using consumer-genomics databases to link living people to ancestors from the recent and not-so-recent past. But the meaning of these connections isn't always clear.
• Build local collaborations for global impact AI翻译
  作者：Lee, Seyoon; Lee, Hanjae; Kim, Juhyun; Kim, Jong-Il
  作者单位：Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU)
• An anti-CRISPR that pulls apart a CRISPR-Cas complex AI翻译
  作者：Trost, Chantel N.; Yang, Jing; Garcia, Bianca; Hidalgo-Reyes, Yurima; Fung, Beatrice C. M.; Wang, Jiuyu; Lu, Wang-Ting; Maxwell, Karen L.; Wang, Yanli; Davidson, Alan R.
  作者单位：University of Toronto; Chinese Academy of Sciences; Institute of Biophysics, CAS; Jiangsu University; University of Toronto; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Toronto; Hospital for Sick Children (SickKids)
  摘要：In biological systems, the activities of macromolecular complexes must sometimes be turned off. Thus, a wide variety of protein inhibitors has evolved for this purpose. These inhibitors function through diverse mechanisms, including steric blocking of crucial interactions, enzymatic modification of key residues or substrates, and perturbation of post-translational modifications1. Anti-CRISPRs-proteins that block the activity of CRISPR-Cas systems-are one of the largest groups of inhibitors des...
• The development of terrestrial ecosystems emerging after glacier retreat AI翻译
  作者：Ficetola, Gentile Francesco; Marta, Silvio; Guerrieri, Alessia; Cantera, Isabel; Bonin, Aurelie; Cauvy-Fraunie, Sophie; Ambrosini, Roberto; Caccianiga, Marco; Anthelme, Fabien; Azzoni, Roberto Sergio; Almond, Peter; Alviz Gazitua, Pablo; Ceballos Lievano, Jorge Luis; Chand, Pritam; Sharma, Milap Chand; Clague, John J.; Cochachin Rapre, Justiniano Alejo; Compostella, Chiara; Cruz Encarnacion, Rolando; Dangles, Olivier; Deline, Philip; Eger, Andre; Erokhin, Sergey; Franzetti, Andrea; Gielly, Ludovic; Gili, Fabrizio; Gobbi, Mauro; Hagvar, Sigmund; Kaufmann, Rudiger; Khedim, Norine; Isela Meneses, Rosa; Morales-Martinez, Marco Aurelio; Peyre, Gwendolyn; Pittino, Francesca; Proietto, Angela; Rabatel, Antoine; Sieron, Katrin; Tielidze, Levan; Urseitova, Nurai; Yang, Yan; Zaginaev, Vitalii; Zerboni, Andrea; Zimmer, Anais; Diolaiuti, Guglielmina Adele; Taberlet, Pierre; Poulenard, Jerome; Fontaneto, Diego; Thuiller, Wilfried; Carteron, Alexis
  作者单位：University of Milan; Universite Savoie Mont Blanc; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); Consiglio Nazionale delle Ricerche (CNR); Istituto di Geoscienze e Georisorse (IGG-CNR); INRAE; University of Milan; Universite de Montpellier; CIRAD; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); INRAE; University of Milan; Lincoln University - New Zealand; Universidad de Los Lagos; Central University of Punjab; Jawaharlal Nehru University, New Delhi; Simon Fraser University; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite Savoie Mont Blanc; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); National Academy of Sciences of the Kyrgyz Republic (NAS KR); University of Milano-Bicocca; University of Turin; Norwegian University of Life Sciences; University of Innsbruck; Universidad Veracruzana; Universidad de los Andes (Colombia); Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Institut de Recherche pour le Developpement (IRD); Communaute Universite Grenoble Alpes; Institut National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); INRAE; Monash University; Ilia State University; Chinese Academy of Sciences; Institute of Mountain Hazards & Environment, CAS; University of Central Asia; University of Texas System; University of Texas Austin; UiT The Arctic University of Tromso; Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca sulle Acque (IRSA-CNR); National Biodiversity Future Center; INRAE; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de Toulouse; Institut National Polytechnique de Toulouse
  摘要：The global retreat of glaciers is dramatically altering mountain and high-latitude landscapes, with new ecosystems developing from apparently barren substrates(1-4). The study of these emerging ecosystems is critical to understanding how climate change interacts with microhabitat and biotic communities and determines the future of ice-free terrains1,5. Here, using a comprehensive characterization of ecosystems (soil properties, microclimate, productivity and biodiversity by environmental DNA m...
• In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution AI翻译
  作者：Renz, Peter F.; Ghoshdastider, Umesh; Sain, Simona Baghai; Valdivia-Francia, Fabiola; Khandekar, Ameya; Ormiston, Mark; Bernasconi, Martino; Dure, Clara; Kretz, Jonas A.; Lee, Minkyoung; Hyams, Katie; Forny, Merima; Pohly, Marcel; Ficht, Xenia; Ellis, Stephanie J.; Moor, Andreas E.; Sendoel, Ataman
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); University of Vienna
  摘要：The tumour evolution model posits that malignant transformation is preceded by randomly distributed driver mutations in cancer genes, which cause clonal expansions in phenotypically normal tissues. Although clonal expansions can remodel entire tissues(1-3), the mechanisms that result in only a small number of clones transforming into malignant tumours remain unknown. Here we develop an in vivo single-cell CRISPR strategy to systematically investigate tissue-wide clonal dynamics of the 150 most...
• Obituary Maxine Singer (1931-2024) AI翻译
  作者：Ferry, Georgina
• Tumour vasculature at single-cell resolution AI翻译
  作者：Pan, Xu; Li, Xin; Dong, Liang; Liu, Teng; Zhang, Min; Zhang, Lining; Zhang, Xiyuan; Huang, Lingjuan; Shi, Wensheng; Sun, Hongyin; Fang, Zhaoyu; Sun, Jie; Huang, Yaoxuan; Shao, Hua; Wang, Yeqi; Yin, Mingzhu
  作者单位：Chongqing University; Chongqing University; Tsinghua University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Chongqing University; Central South University; Central South University; Southern Medical University - China; Central South University; Chongqing University
  摘要：Tumours can obtain nutrients and oxygen required to progress and metastasize through the blood supply(1). Inducing angiogenesis involves the sprouting of established vessel beds and their maturation into an organized network(2,3). Here we generate a comprehensive atlas of tumour vasculature at single-cell resolution, encompassing approximately 200,000 cells from 372 donors representing 31 cancer types. Trajectory inference suggested that tumour angiogenesis was initiated from venous endothelia...