The cortical amygdala consolidates a socially transmitted long-term memory
成果类型：
Article
署名作者：
Liu, Zhihui; Sun, Wenfei; Ng, Yi Han; Dong, Hua; Quake, Stephen R.; Sudhof, Thomas C.
署名单位：
Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
刊物名称：
Nature
ISSN/ISSBN：
0028-6930
DOI：
10.1038/s41586-024-07632-5
发表日期：
2024-08-08
页码：
366-+
关键词：
prelimbic cortex impairs
food preferences
basolateral amygdala
synaptic plasticity
retrograde-amnesia
receptor blockade
olfactory memory
basal forebrain
fos expression
rna-seq
摘要：
Social communication guides decision-making, which is essential for survival. Social transmission of food preference (STFP) is an ecologically relevant memory paradigm in which an animal learns a desirable food odour from another animal in a social context, creating a long-term memory(1,2). How food-preference memory is acquired, consolidated and stored is unclear. Here we show that the posteromedial nucleus of the cortical amygdala (COApm) serves as a computational centre in long-term STFP memory consolidation by integrating social and sensory olfactory inputs. Blocking synaptic signalling by the COApm-based circuit selectively abolished STFP memory consolidation without impairing memory acquisition, storage or recall. COApm-mediated STFP memory consolidation depends on synaptic inputs from the accessory olfactory bulb and on synaptic outputs to the anterior olfactory nucleus. STFP memory consolidation requires protein synthesis, suggesting a gene-expression mechanism. Deep single-cell and spatially resolved transcriptomics revealed robust but distinct gene-expression signatures induced by STFP memory formation in the COApm that are consistent with synapse restructuring. Our data thus define a neural circuit for the consolidation of a socially communicated long-term memory, thereby mechanistically distinguishing protein-synthesis-dependent memory consolidation from memory acquisition, storage or retrieval.