8034期

最新文章

• Six tips for going public with your lab's software AI翻译
  作者：Nowogrodzki, Julian
• Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission AI翻译
  作者：Bai, Zhiliang; Feng, Bing; McClory, Susan E.; de Oliveira, Beatriz Coutinho; Diorio, Caroline; Gregoire, Celine; Tao, Bo; Yang, Luojia; Zhao, Ziran; Peng, Lei; Sferruzza, Giacomo; Zhou, Liqun; Zhou, Xiaolei; Kerr, Jessica; Baysoy, Alev; Su, Graham; Yang, Mingyu; Camara, Pablo G.; Chen, Sidi; Tang, Li; June, Carl H.; Melenhorst, J. Joseph; Grupp, Stephan A.; Fan, Rong
  作者单位：Yale University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Cleveland Clinic Foundation; Yale University; Yale University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Yale University; Yale University; Yale University; Yale New Haven Hospital
  摘要：Despite a high response rate in chimeric antigen receptor (CAR) T cell therapy for acute lymphocytic leukaemia (ALL)(1-3), approximately 50% of patients relapse within the first year(4-6), representing an urgent question to address in the next stage of cellular immunotherapy. Here, to investigate the molecular determinants of ultralong CAR T cell persistence, we obtained a single-cell multi-omics atlas from 695,819 pre-infusion CAR T cells at the basal level or after CAR-specific stimulation f...
• Jet stream controls on European climate and agriculture since 1300 CE AI翻译
  作者：Xu, Guobao; Broadman, Ellie; Dorado-Linan, Isabel; Klippel, Lara; Meko, Matthew; Buntgen, Ulf; De Mil, Tom; Esper, Jan; Gunnarson, Bjorn; Hartl, Claudia; Krusic, Paul J.; Linderholm, Hans W.; Ljungqvist, Fredrik C.; Ludlow, Francis; Panayotov, Momchil; Seim, Andrea; Wilson, Rob; Zamora-Reyes, Diana; Trouet, Valerie
  作者单位：Northwest University Xi'an; University of Arizona; Chinese Academy of Sciences; Universidad Politecnica de Madrid; Deutscher Wetterdienst; University of Cambridge; Czech Academy of Sciences; Global Change Research Centre of the Czech Academy of Sciences; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Masaryk University; University of Liege; Johannes Gutenberg University of Mainz; Stockholm University; Justus Liebig University Giessen; Stockholm University; University of Gothenburg; Stockholm University; Swedish Collegium for Advanced Study (SCAS); Trinity College Dublin; Trinity College Dublin; University of Forestry - Bulgaria; University of Freiburg; University of Innsbruck; University of St Andrews
  摘要：The jet stream is an important dynamic driver of climate variability in the Northern Hemisphere mid-latitudes(1-3). Modern variability in the position of summer jet stream latitude in the North Atlantic-European sector (EU JSL) promotes dipole patterns in air pressure, temperature, precipitation and drought between northwestern and southeastern Europe. EU JSL variability and its impacts on regional climatic extremes and societal events are poorly understood, particularly before anthropogenic w...
• The ultra-high affinity transport proteins of ubiquitous marine bacteria AI翻译
  作者：Clifton, Ben E.; Alcolombri, Uria; Uechi, Gen-Ichiro; Jackson, Colin J.; Laurino, Paola
  作者单位：Okinawa Institute of Science & Technology Graduate University; Hebrew University of Jerusalem; Australian National University; Australian National University; Australian National University; University of Osaka
  摘要：SAR11 bacteria are the most abundant microorganisms in the surface ocean(1) and have global biogeochemical importance(2-4). To thrive in their competitive oligotrophic environment, these bacteria rely heavily on solute-binding proteins that facilitate uptake of specific substrates via membrane transporters(5,6). The functions and properties of these transport proteins are key factors in the assimilation of dissolved organic matter and biogeochemical cycling of nutrients in the ocean, but they ...
• Medicine Nobel awarded for gene-regulating Discovery AI翻译
  作者：Callaway, Ewen; Sanderson, Katharine
• Chemistry Nobel goes to developers of AlphaFold AI that predicts protein structures AI翻译
  作者：Callaway, Ewen
  摘要：This year's prize celebrates computational tools that have transformed biology and have the potential to revolutionize drug discovery.
• Physics Nobel scooped by machine-learning pioneers AI翻译
  作者：Gibney, Elizabeth; Castelvecchi, Davide
  摘要：John Hopfield and Geoffrey Hinton pioneered computational methods that enabled the development of neural networks.
• Believe it or not, this lush landscape is Antarctica AI翻译
  作者：Soliman, Alix
  摘要：Vegetation is spreading at an alarming rate in a place where temperatures are soaring.
• Converting chaos into order: aerial archaeology takes flight in the 1920s AI翻译
  作者：[Anonymous]
• Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C AI翻译
  作者：Arseni, Diana; Nonaka, Takashi; Jacobsen, Max H.; Murzin, Alexey G.; Cracco, Laura; Peak-Chew, Sew Y.; Garringer, Holly J.; Kawakami, Ito; Suzuki, Hisaomi; Onaya, Misumoto; Saito, Yuko; Murayama, Shigeo; Geula, Changiz; Vidal, Ruben; Newell, Kathy L.; Mesulam, Marsel; Ghetti, Bernardino; Hasegawa, Masato; Ryskeldi-Falcon, Benjamin
  作者单位：MRC Laboratory Molecular Biology; Tokyo Metropolitan Institute of Medical Science; Indiana University System; Indiana University Indianapolis; Northwestern University; Feinberg School of Medicine
  摘要：Neurodegenerative diseases are characterized by the abnormal filamentous assembly of specific proteins in the central nervous system1. Human genetic studies have established a causal role for protein assembly in neurodegeneration2. However, the underlying molecular mechanisms remain largely unknown, which is limiting progress in developing clinical tools for these diseases. Recent advances in cryo-electron microscopy have enabled the structures of the protein filaments to be determined from th...