8034期

最新文章

• Make secondary microplastics a primary UN concern AI翻译
  作者：Diana, Zoie T.; Rochman, Chelsea M.; Mallos, Nicholas
  作者单位：University of Toronto
• Robust chemical analysis with graphene chemosensors and machine learning AI翻译
  作者：Pannone, Andrew; Raj, Aditya; Ravichandran, Harikrishnan; Das, Sarbashis; Chen, Ziheng; Price, Collin A.; Sultana, Mahmooda; Das, Saptarshi
  作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
• Temporal BMP4 effects on mouse embryonic and extraembryonic development AI翻译
  作者：Hadas, Ron; Rubinstein, Hernan; Mittnenzweig, Markus; Mayshar, Yoav; Ben-Yair, Raz; Cheng, Saifeng; Aguilera-Castrejon, Alejandro; Reines, Netta; Orenbuch, Ayelet-Hashahar; Lifshitz, Aviezer; Chen, Dong-Yuan; Elowitz, Michael B.; Zernicka-Goetz, Magdalena; Hanna, Jacob H.; Tanay, Amos; Stelzer, Yonatan
  作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science; California Institute of Technology; University of Cambridge
  摘要：The developing placenta, which in mice originates through the extraembryonic ectoderm (ExE), is essential for mammalian embryonic development. Yet unbiased characterization of the differentiation dynamics of the ExE and its interactions with the embryo proper remains incomplete. Here we develop a temporal single-cell model of mouse gastrulation that maps continuous and parallel differentiation in embryonic and extraembryonic lineages. This is matched with a three-way perturbation approach to t...
• Diverse viral cas genes antagonize CRISPR immunity AI翻译
  作者：Katz, Mark A.; Sawyer, Edith M.; Oriolt, Luke; Kozlova, Albina; Williams, Madison C.; Margolis, Shally R.; Johnson, Matthew; Bondy-Denomy, Joseph; Meeske, Alexander J.
  作者单位：University of Washington; University of Washington Seattle; University of California System; University of California San Francisco
  摘要：Prokaryotic CRISPR-Cas immunity is subverted by anti-CRISPRs (Acrs), which inhibit Cas protein activities when expressed during the phage lytic cycle or from resident prophages or plasmids1. Acrs often bind to specific cognate Cas proteins, and hence inhibition is typically limited to a single CRISPR-Cas subtype2. Furthermore, although acr genes are frequently organized together in phage-associated gene clusters3, how such inhibitors initially evolve has remained unclear. Here we investigated ...
• The type 2 cytokine Fc-IL-4 revitalizes exhausted CD8+ T cells against cancer AI翻译
  作者：Feng, Bing; Bai, Zhiliang; Zhou, Xiaolei; Zhao, Yang; Xie, Yu-Qing; Huang, Xinyi; Liu, Yang; Enbar, Tom; Li, Rongrong; Wang, Yi; Gao, Min; Bonati, Lucia; Peng, Mei-Wen; Li, Weilin; Tao, Bo; Charmoy, Melanie; Held, Werner; Melenhorst, J. Joseph; Fan, Rong; Guo, Yugang; Tang, Li
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Yale University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Yale University; University of Lausanne; Cleveland Clinic Foundation; Zhejiang University; Zhejiang University; Zhejiang University
  摘要：Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses fighting cancer; however, long-term complete remission remains uncommon(1,2). A pivotal question arises as to whether type 2 immunity can be orchestrated alongside type 1-centric immunotherapy to achieve enduring response against cancer(3,4). Here we show that an interleukin-4 fusion protein (Fc-IL-4), a typical type 2 cytokine, directly acts on CD8(+) T cells and enriches functional terminally exhausted CD...
• MARBURG VIRUS IS RISING IN RWANDA: WHY SCIENTISTS ARE WORRIED AI翻译
  作者：Sidik, Saima
• Evidence of dead people posed on dead horses found in ancient tomb AI翻译
  作者：[Anonymous]
• Differences in misinformation sharing can lead to politically asymmetric sanctions AI翻译
  作者：Mosleh, Mohsen; Yang, Qi; Zaman, Tauhid; Pennycook, Gordon; Rand, David G.
  作者单位：University of Oxford; University of Exeter; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Yale University; Cornell University; Massachusetts Institute of Technology (MIT)
  摘要：In response to intense pressure, technology companies have enacted policies to combat misinformation(1-4). The enforcement of these policies has, however, led to technology companies being regularly accused of political bias(5-7). We argue that differential sharing of misinformation by people identifying with different political groups(8-15) could lead to political asymmetries in enforcement, even by unbiased policies. We first analysed 9,000 politically active Twitter users during the US 2020...
• High-performance 4-nm-resolution X-ray tomography using burst ptychography (vol 632, pg 81, 2024) AI翻译
  作者：Aidukas, Tomas; Phillips, Nicholas W.; Diaz, Ana; Poghosyan, Emiliya; Muller, Elisabeth; Levi, A. F. J.; Aeppli, Gabriel; Guizar-Sicairos, Manuel; Holler, Mirko
• Molecular programs guiding arealization of descending cortical pathways AI翻译
  作者：Abe, Philipp; Lavalley, Adrien; Morassut, Ilaria; Santinha, Antonio J.; Roig-Puiggros, Sergi; Javed, Awais; Klingler, Esther; Baumann, Natalia; Prados, Julien; Platt, Randall J.; Jabaudon, Denis
  作者单位：University of Geneva; Technische Universitat Dresden; Carl Gustav Carus University Hospital; University of Geneva; Swiss Federal Institutes of Technology Domain; ETH Zurich; Flanders Institute for Biotechnology (VIB); University of Geneva; University of Basel; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite
  摘要：Layer 5 extratelencephalic (ET) neurons are present across neocortical areas and send axons to multiple subcortical targets1-6. Two cardinal subtypes exist7,8: (1) Slco2a1-expressing neurons (ETdist), which predominate in the motor cortex and project distally to the pons, medulla and spinal cord; and (2) Nprs1- or Hpgd-expressing neurons (ETprox), which predominate in the visual cortex and project more proximally to the pons and thalamus. An understanding of how area-specific ETdist and ETprox...