8036期

最新文章

• Biomolecular condensates mediate bending and scission of endosome membranes AI翻译
  作者：Wang, Yanning; Li, Shulin; Mokbel, Marcel; May, Alexander I.; Liang, Zizhen; Zeng, Yonglun; Wang, Weiqi; Zhang, Honghong; Yu, Feifei; Sporbeck, Katharina; Jiang, Liwen; Aland, Sebastian; Agudo-Canalejo, Jaime; Knorr, Roland L.; Fang, Xiaofeng
  作者单位：Tsinghua University; Technical University Freiberg; Humboldt University of Berlin; Institute of Science Tokyo; Tokyo Institute of Technology; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese Academy of Sciences; South China Botanical Garden, CAS; Chinese Academy of Sciences; South China Botanical Garden, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; China Agricultural University; Max Planck Society; University of London; University College London; University of Tokyo; University of Cologne; University of Cologne
  摘要：Multivesicular bodies are key endosomal compartments implicated in cellular quality control through their degradation of membrane-bound cargo proteins(1-3). The ATP-consuming ESCRT protein machinery mediates the capture and engulfment of membrane-bound cargo proteins through invagination and scission of multivesicular-body membranes to form intraluminal vesicles(4,5). Here we report that the plant ESCRT component FREE1(6) forms liquid-like condensates that associate with membranes to drive int...
• AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases AI翻译
  作者：Li, Heyu; Liu, Chao; Li, Ran; Zhou, Lili; Ran, Yu; Yang, Qiqing; Huang, Huizhe; Lu, Huasong; Song, Hai; Yang, Bing; Ru, Heng; Lin, Shixian; Zhang, Long
  作者单位：Zhejiang University; Zhejiang University; Hangzhou City University; Soochow University - China; Chongqing Medical University; Nanchang University; Zhejiang University
  摘要：l-lactate modifies proteins through lactylation1, but how this process occurs is unclear. Here we identify the alanyl-tRNA synthetases AARS1 and AARS2 (AARS1/2) as intracellular l-lactate sensors required for l-lactate to stimulate the lysine lactylome in cells. AARS1/2 and the evolutionarily conserved Escherichia coli orthologue AlaRS bind to l-lactate with micromolar affinity and they directly catalyse l-lactate for ATP-dependent lactylation on the lysine acceptor end. In response to l-lacta...
• Prestigious Japanese biomedical awards need to become more gender-representative AI翻译
  作者：Hakariya, Hayase
  作者单位：Eberhard Karls University of Tubingen
• 'Educational' apps are worth billions. We need to make sure they work AI翻译
  作者：Kucirkova, Natalia I.
  作者单位：Universitetet i Stavanger
  摘要：The past year has seen bans on the use of smartphones in schools in some 60 countries, including the Netherlands, France and the United States. The restrictions come amid spreading worry that social media can harm children's mental health. It's a valid concern. But in the heat of the discussion, other technologies used by children - such as educational technology (edtech) - are flying under the radar.
• Rapid 3D printing at the curved surface of a liquid AI翻译
  作者：Taylor, Hayden
  作者单位：University of California System; University of California Berkeley
• Smooth trends in fermium charge radii and the impact of shell effects AI翻译
  作者：Warbinek, Jessica; Rickert, Elisabeth; Raeder, Sebastian; Albrecht-Schonzart, Thomas; Andelic, Brankica; Auler, Julian; Bally, Benjamin; Bender, Michael; Berndt, Sebastian; Block, Michael; Brizard, Alexandre; Chauveau, Pierre; Cheal, Bradley; Chhetri, Premaditya; Claessens, Arno; de Roubin, Antoine; Devlin, Charlie; Dorrer, Holger; Duellmann, Christoph E.; Ezold, Julie; Ferrer, Rafael; Gadelshin, Vadim; Gaiser, Alyssa; Giacoppo, Francesca; Goriely, Stephane; Gutierrez, Manuel J.; Harvey, Ashley; Hasse, Raphael; Heinke, Reinhard; Hessberger, Fritz-Peter; Hilaire, Stephane; Kaja, Magdalena; Kaleja, Oliver; Kieck, Tom; Kim, Eunkang; Kneip, Nina; Koester, Ulli; Kraemer, Sandro; Laatiaoui, Mustapha; Lantis, Jeremy; Lecesne, Nathalie; Loria Basto, Andrea Tzeitel; Mistry, Andrew Kishor; Mokry, Christoph; Moore, Iain; Murboeck, Tobias; Muenzberg, Danny; Nazarewicz, Witold; Niemeyer, Thorben; Nothhelfer, Steven; Peru, Sophie; Raggio, Andrea; Reinhard, Paul-Gerhard; Renisch, Dennis; Rey-Herme, Emmanuel; Romans, Jekabs; Romero Romero, Elisa; Runke, Joerg; Ryssens, Wouter; Savajols, Herve; Schneider, Fabian; Sperling, Joseph; Stemmler, Matou; Studer, Dominik; Thoerle-Pospiech, Petra; Trautmann, Norbert; Urquiza-Gonzalez, Mitzi; van Beek, Kenneth; Van Cleve, Shelley; Van Duppen, Piet; Vandebrouck, Marine; Verstraelen, Elise; Walther, Thomas; Weber, Felix; Wendt, Klaus
  作者单位：Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Johannes Gutenberg University of Mainz; Colorado School of Mines; University of Groningen; Universite Paris Saclay; CEA; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute of Nuclear and Particle Physics (IN2P3); Universite Claude Bernard Lyon 1; CEA; University of Liverpool; KU Leuven; United States Department of Energy (DOE); Oak Ridge National Laboratory; Johannes Gutenberg University of Mainz; Michigan State University; Michigan State University; Universite Libre de Bruxelles; CEA; Universite Paris Saclay; CEA; Universitat Greifswald; Institut Laue-Langevin (ILL); Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Technical University of Darmstadt; University of Jyvaskyla; Michigan State University; University of Erlangen Nuremberg; CEA; Universite Paris Saclay; University of Gothenburg; European Organization for Nuclear Research (CERN)
  摘要：The quantum-mechanical nuclear-shell structure determines the stability and limits of the existence of the heaviest nuclides with large proton numbers Z greater than or similar to 100 (refs. 1-3). Shell effects also affect the sizes and shapes of atomic nuclei, as shown by laser spectroscopy studies in lighter nuclides4. However, experimental information on the charge radii and the nuclear moments of the heavy actinide elements, which link the heaviest naturally abundant nuclides with artifici...
• Strain could enable energy-saving computer memories AI翻译
  作者：Gattinoni, Chiara
  作者单位：University of London; King's College London
• Nitrogen-doped amorphous monolayer carbon ( oct , 2024 , 10.1038/s41586-024-08147-9 ) AI翻译
  作者：Bai, Xiuhui; Hu, Pengfei; Li, Ang; Zhang, Youwei; Li, Aowen; Zhang, Guangjie; Xue, Yufeng; Jiang, Tianxing; Wang, Zezhou; Cui, Hanke; Kang, Jianxin; Zhao, Hewei; Gu, Lin; Zhou, Wu; Liu, Li-Min; Qiu, Xiaohui; Guo, Lin
  作者单位：Beihang University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Beihang University; Tsinghua University; Tsinghua University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
• CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells AI翻译
  作者：Ruetz, Tyson J.; Pogson, Angela N.; Kashiwagi, Chloe M.; Gagnon, Stephanie D.; Morton, Bhek; Sun, Eric D.; Na, Jeeyoon; Yeo, Robin W.; Leeman, Dena S.; Morgens, David W.; Tsui, C. Kimberly; Li, Amy; Bassik, Michael C.; Brunet, Anne
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University
  摘要：Ageing impairs the ability of neural stem cells (NSCs) to transition from quiescence to proliferation in the adult mammalian brain. Functional decline of NSCs results in the decreased production of new neurons and defective regeneration following injury during ageing(1-4). Several genetic interventions have been found to ameliorate old brain function(5-8), but systematic functional testing of genes in old NSCs-and more generally in old cells-has not been done. Here we develop in vitro and in v...
• European hedgehog's 'near threatened' listing raises concerns for an iconic species AI翻译
  作者：Gazzard, Abigail; Macdonald, David W.; Lund Rasmussen, Sophie
  作者单位：University of Oxford