作者：Chi, Zhexu; Chen, Sheng; Yang, Dehang; Cui, Wenyu; Lu, Yang; Wang, Zhen; Li, Mobai; Yu, Weiwei; Zhang, Jian; Jiang, Yu; Sun, Ruya; Yu, Qianzhou; Hu, Tianyi; Lu, Xiaoyang; Deng, Qiqi; Yang, Yidong; Zhao, Tianming; Chang, Mengfei; Li, Yuying; Zhang, Xue; Shang, Min; Xiao, Qian; Ding, Kefeng; Wang, Di
作者单位：Zhejiang University; Zhejiang University; Liangzhu Laboratory; Zhejiang University; Zhejiang University; Zhejiang University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Zhejiang University; Zhejiang University
摘要：The establishment of an early pro-regenerative niche is crucial for tissue regeneration1,2. Gasdermin D (GSDMD)-dependent pyroptosis accounts for the release of inflammatory cytokines upon various insults3-5. However, little is known about its role in tissue regeneration followed by homeostatic maintenance. Here we show that macrophage GSDMD deficiency delays tissue recovery but has little effect on the local inflammatory milieu or the lytic pyroptosis process. Profiling of the metabolite secr...
作者：Mo, Chia-Kuei; Liu, Jingxian; Chen, Siqi; Storrs, Erik; Targino da Costa, Andre Luiz N.; Houston, Andrew; Wendl, Michael C.; Jayasinghe, Reyka G.; Iglesia, Michael D.; Ma, Cong; Herndon, John M.; Southard-Smith, Austin N.; Liu, Xinhao; Mudd, Jacqueline; Karpova, Alla; Shinkle, Andrew; Goedegebuure, S. Peter; Abdelzaher, Abdurrahman Taha Mousa Ali; Bo, Peng; Fulghum, Lauren; Livingston, Samantha; Balaban, Metin; Hill, Angela; Ippolito, Joseph E.; Thorsson, Vesteinn; Held, Jason M.; Hagemann, Ian S.; Kim, Eric H.; Bayguinov, Peter O.; Kim, Albert H.; Mullen, Mary M.; Shoghi, Kooresh I.; Ju, Tao; Reimers, Melissa A.; Weimholt, Cody; Kang, Liang-, I; Puram, Sidharth V.; Veis, Deborah J.; Pachynski, Russell; Fuh, Katherine C.; Chheda, Milan G.; Gillanders, William E.; Fields, Ryan C.; Raphael, Benjamin J.; Chen, Feng; Ding, Li
作者单位：Washington University (WUSTL); Washington University (WUSTL); Princeton University; Washington University (WUSTL); Washington University (WUSTL); Siteman Cancer Center; Washington University (WUSTL); Institute for Systems Biology (ISB); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); University of California System; University of California San Francisco
摘要：To study the spatial interactions among cancer and non-cancer cells1, we here examined a cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial transcriptomics (ST). This was combined with 48 matched single-nucleus RNA sequencing samples and 22 matched co-detection by indexing (CODEX) samples. To describe tumour structures and habitats, we defined 'tumour microregions' as spatially distinct cancer cell clusters separated by stromal components. They varied in size a...
