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作者：Li, Erwei; Wang, Luhong; Wang, Daqing; Chi, Jingyi; Lin, Zeran; Smith, Gordon I.; Klein, Samuel; Cohen, Paul; Rosen, Evan D.
作者单位：Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Rockefeller University; Washington University (WUSTL); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Oxytocin (OXT), a nine-amino-acid peptide produced in the hypothalamus and released by the posterior pituitary, has well-known actions in parturition, lactation and social behaviour1, and has become an intriguing therapeutic target for conditions such as autism and schizophrenia2. Exogenous OXT has also been shown to have effects on body weight, lipid levels and glucose homeostasis1,3, suggesting that it may also have therapeutic potential for metabolic disease1,4. It is unclear, however, whet...
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作者：Castelvecchi, Davide
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作者：Tollefson, Jeff
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作者：Zhao, Jian; Ji, Peixuan; Li, Yaqi; Li, Rui; Zhang, Kaimin; Tian, Hao; Yu, Kaicheng; Bian, Boyue; Hao, Luzhen; Xiao, Xue; Griffin, Will; Dudeck, Noel; Moro, Ramiro; Ma, Lei; de Heer, Walt A.
作者单位：Tianjin University; University System of Georgia; Georgia Institute of Technology
摘要：Semiconducting graphene plays an important part in graphene nanoelectronics because of the lack of an intrinsic bandgap in graphene1. In the past two decades, attempts to modify the bandgap either by quantum confinement or by chemical functionalization failed to produce viable semiconducting graphene. Here we demonstrate that semiconducting epigraphene (SEG) on single-crystal silicon carbide substrates has a band gap of 0.6 eV and room temperature mobilities exceeding 5,000 cm2 V-1 s-1, which ...
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作者：Loevestam, Sofia; Li, David; Wagstaff, Jane L.; Kotecha, Abhay; Kimanius, Dari; McLaughlin, Stephen H.; Murzin, Alexey G.; Freund, Stefan M. V.; Goedert, Michel; Scheres, Sjors H. W.
作者单位：MRC Laboratory Molecular Biology; Thermo Fisher Scientific
摘要：Intermediate species in the assembly of amyloid filaments are believed to play a central role in neurodegenerative diseases and may constitute important targets for therapeutic intervention1,2. However, structural information about intermediate species has been scarce and the molecular mechanisms by which amyloids assemble remain largely unknown. Here we use time-resolved cryogenic electron microscopy to study the in vitro assembly of recombinant truncated tau (amino acid residues 297-391) int...
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作者：LaMarche, Nelson M.; Hegde, Samarth; Park, Matthew D.; Maier, Barbara B.; Troncoso, Leanna; Le Berichel, Jessica; Hamon, Pauline; Belabed, Meriem; Mattiuz, Raphael; Hennequin, Clotilde; Chin, Theodore; Reid, Amanda M.; Reyes-Torres, Ivan; Nemeth, Erika; Zhang, Ruiyuan; Olson, Oakley C.; Doroshow, Deborah B.; Rohs, Nicholas C.; Gomez, Jorge E.; Veluswamy, Rajwanth; Hall, Nicole; Venturini, Nicholas; Ginhoux, Florent; Liu, Zhaoyuan; Buckup, Mark; Figueiredo, Igor; Roudko, Vladimir; Miyake, Kensuke; Karasuyama, Hajime; Gonzalez-Kozlova, Edgar; Gnjatic, Sacha; Passegue, Emmanuelle; Kim-Schulze, Seunghee; Brown, Brian D.; Hirsch, Fred R.; Kim, Brian S.; Marron, Thomas U.; Merad, Miriam
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Columbia University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Gustave Roussy; Universite Paris Saclay; Chinese Academy of Sciences; Shanghai Jiao Tong University; Icahn School of Medicine at Mount Sinai; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
摘要：Myeloid cells are known to suppress antitumour immunity(1). However, the molecular drivers of immunosuppressive myeloid cell states are not well defined. Here we used single-cell RNA sequencing of human and mouse non-small cell lung cancer (NSCLC) lesions, and found that in both species the type 2 cytokine interleukin-4 (IL-4) was predicted to be the primary driver of the tumour-infiltrating monocyte-derived macrophage phenotype. Using a panel of conditional knockout mice, we found that only d...
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作者：Alesina, Alberto; Hohmann, Sebastian; Michalopoulos, Stelios; Papaioannou, Elias
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作者：Maus, Victor; Werner, Tim T.
作者单位：Vienna University of Economics & Business; International Institute for Applied Systems Analysis (IIASA); University of Melbourne
摘要：As the race to extract minerals and metals for clean-energy technologies accelerates, researchers must take more steps to map and study mines globally.
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作者：Ruggeri, Kai; Stock, Friederike; Haslam, S. Alexander; Capraro, Valerio; Boggio, Paulo; Ellemers, Naomi; Cichocka, Aleksandra; Douglas, Karen M.; Rand, David G.; van der Linden, Sander; Cikara, Mina; Finkel, Eli J.; Druckman, James N.; Wohl, Michael J. A.; Petty, Richard E.; Tucker, Joshua A.; Shariff, Azim; Gelfand, Michele; Packer, Dominic; Jetten, Jolanda; Van Lange, Paul A. M.; Pennycook, Gordon; Peters, Ellen; Baicker, Katherine; Crum, Alia; Weeden, Kim A.; Napper, Lucy; Tabri, Nassim; Zaki, Jamil; Skitka, Linda; Kitayama, Shinobu; Mobbs, Dean; Sunstein, Cass R.; Ashcroft-Jones, Sarah; Todsen, Anna Louise; Hajian, Ali; Verra, Sanne; Buehler, Vanessa; Friedemann, Maja; Hecht, Marlene; Mobarak, Rayyan S.; Karakasheva, Ralitsa; Tunte, Markus R.; Yeung, Siu Kit; Rosenbaum, R. Shayna; Yamada, Yuki; Hudson, Sa-kiera Tiarra Jolynn; Macchia, Lucia; Soboleva, Irina; Dimant, Eugen; Geiger, Sandra J.; Jarke, Hannes; Wingen, Tobias; Berkessel, Jana B.; Mareva, Silvana; McGill, Lucy; Papa, Francesca; Veckalov, Bojana; Afif, Zeina; Buabang, Eike K.; Landman, Marna; Tavera, Felice; Andrews, Jack L.; Bursaloglu, Asl; Zupan, Zorana; Wagner, Lisa; Navajas, Joaquin; Vranka, Marek; Kasdan, David; Chen, Patricia; Hudson, Kathleen R.; Novak, Lindsay M.; Teas, Paul; Rachev, Nikolay R.; Galizzi, Matteo M.; Milkman, Katherine L.; Petrovic, Marija; Van Bavel, Jay J.; Willer, Robb
作者单位：Columbia University; University of Cambridge; United States Department of Defense; United States Air Force; Max Planck Society; Humboldt University of Berlin; University of Queensland; University of Milano-Bicocca; Universidade Presbiteriana Mackenzie; Utrecht University; University of Kent; Massachusetts Institute of Technology (MIT); University of Cambridge; Harvard University; Northwestern University; Northwestern University; Northwestern University; Carleton University; University System of Ohio; Ohio State University; New York University; New York University; University of British Columbia; Stanford University; Lehigh University; Vrije Universiteit Amsterdam; University of Cologne; Cornell University; University of Oregon; University of Oregon; University of Chicago; Stanford University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Michigan System; University of Michigan; California Institute of Technology; California Institute of Technology; University of Oxford; University of Oxford; University of Tehran; University of Oxford; University System of Maryland; University of Maryland College Park; University of Vienna; Chinese University of Hong Kong; York University - Canada; University of Toronto; Baycrest; University of Ljubljana; Kyushu University; University of California System; University of California Berkeley; City St Georges, University of London; Duke Kunshan University; University of Pennsylvania; Leibniz Association; Ifo Institut; University of Vienna; University of Bonn; University of Mannheim; University of Cambridge; University of Exeter; University College Dublin; University of Groningen; Organisation for Economic Co-operation & Development (OECD); University of Amsterdam; The World Bank; Trinity College Dublin; University of Pretoria; University of Cologne; University of Oxford; Loyola University Chicago; University of Belgrade; University of Zurich; University of Zurich; Universidad Torcuato Di Tella; Universidad Torcuato Di Tella; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Charles University Prague; Sungkyunkwan University (SKKU); University of Texas System; University of Texas Austin; National University of Singapore; University of Sofia; University of London; London School Economics & Political Science; University of Pennsylvania; University of Belgrade; University of Belgrade; New York University; New York University; Stanford University
摘要：Scientific evidence regularly guides policy decisions(1), with behavioural science increasingly part of this process(2). In April 2020, an influential paper(3) proposed 19 policy recommendations ('claims') detailing how evidence from behavioural science could contribute to efforts to reduce impacts and end the COVID-19 pandemic. Here we assess 747 pandemic-related research articles that empirically investigated those claims. We report the scale of evidence and whether evidence supports them to...
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作者：Russell, Andrew J. C.; Weir, Jackson A.; Nadaf, Naeem M.; Shabet, Matthew; Kumar, Vipin; Kambhampati, Sandeep; Raichur, Ruth; Marrero, Giovanni J.; Liu, Sophia; Balderrama, Karol S.; Vanderburg, Charles R.; Shanmugam, Vignesh; Tian, Luyi; Iorgulescu, J. Bryan; Yoon, Charles H.; Wu, Catherine J.; Macosko, Evan Z.; Chen, Fei
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Guangzhou Laboratory; University of Texas System; UTMD Anderson Cancer Center
摘要：Recent technological innovations have enabled the high-throughput quantification of gene expression and epigenetic regulation within individual cells, transforming our understanding of how complex tissues are constructed1-6. However, missing from these measurements is the ability to routinely and easily spatially localize these profiled cells. We developed a strategy, Slide-tags, in which single nuclei within an intact tissue section are tagged with spatial barcode oligonucleotides derived fro...
