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作者：Tursi, Nicholas J.; Weiner, David B.
作者单位：The Wistar Institute; University of Pennsylvania; University of Pennsylvania
摘要：Modified components of messenger RNA can cause the protein-production machinery to stall during the process of translation. This might change the protein being made, a finding with implications for vaccines or therapies.
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作者：Dhindsa, Ryan S.; Petrovski, Slave
作者单位：Baylor College of Medicine; AstraZeneca; AstraZeneca
摘要：An expanded version of a human-genome database called gnomAD, containing 76,156 whole-genome sequences, has enabled investigation of how variants in non-protein-coding regions of the genome affect health.
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作者：Shi, Hailing; He, Yichun; Zhou, Yiming; Huang, Jiahao; Maher, Kamal; Wang, Brandon; Tang, Zefang; Luo, Shuchen; Tan, Peng; Wu, Morgan; Lin, Zuwan; Ren, Jingyi; Thapa, Yaman; Tang, Xin; Chan, Ken Y.; Deverman, Benjamin E.; Shen, Hao; Liu, Albert; Liu, Jia; Wang, Xiao
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
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作者：[Anonymous]
摘要：The threat of antimicrobial resistance means that new antibiotics need to be used sparingly. Governments must support their development with a long-term funding plan.
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作者：Manno, Francis A. M.
作者单位：University of North Carolina; East Carolina University
摘要：Letter to the Editor
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作者：Nogrady, Bianca
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作者：Palmer, Jane
摘要：Don't rely solely on academic papers to raise your professional profile. General readers are interested in your opinions, too.
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作者：Thompson, Tosin
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作者：Mulroney, Thomas E.; Poyry, Tuija; Yam-Puc, Juan Carlos; Rust, Maria; Harvey, Robert F.; Kalmar, Lajos; Horner, Emily; Booth, Lucy; Ferreira, Alexander P.; Stoneley, Mark; Sawarkar, Ritwick; Mentzer, Alexander J.; Lilley, Kathryn S.; Smales, C. Mark; von der Haar, Tobias; Turtle, Lance; Dunachie, Susanna; Klenerman, Paul; Thaventhiran, James E. D.; Willis, Anne E.
作者单位：University of Cambridge; University of Oxford; Wellcome Centre for Human Genetics; University of Cambridge; University of Kent; University College Dublin; University of Liverpool; Oxford University Hospitals NHS Foundation Trust; University of Oxford; University of Oxford; Mahidol Oxford Tropical Medicine Research Unit (MORU); Mahidol University; University of Oxford
摘要：In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IVT mRNAs are transfected into target cells, where they are translated into recombinant protein, and the biological activity or immunogenicity of the encoded protein exerts an intended therapeutic effect(1,2). Modified ribonucleotides are commonly incorporated into therapeutic IVT mRNAs to decrease their innate imm...
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作者：McLeod, Anna F.; Klaassen, Pamela D.; Reiter, Megan; Henshaw, Jonathan; Kuiper, Rolf; Ginsburg, Adam
作者单位：Durham University; Durham University; University of Edinburgh; Rice University; Liverpool John Moores University; Max Planck Society; University of Duisburg Essen; State University System of Florida; University of Florida
摘要：The canonical picture of star formation involves disk-mediated accretion, with Keplerian accretion disks and associated bipolar jets primarily observed in nearby, low-mass young stellar objects (YSOs). Recently, rotating gaseous structures and Keplerian disks have been detected around several massive (M > 8 M-circle dot) YSOs (MYSOs)(1-4), including several disk-jet systems(5-7). All the known MYSO systems are in the Milky Way, and all are embedded in their natal material. Here we report the d...
