2024

最新文章

• How human brains got so big: our cells learned to handle the stress that comes with size AI翻译
  作者：Naddaf, Miryam
  摘要：Understanding how human neurons cope with the energy demands of a large, active brain could open up new avenues for treating neurological disorders.
• The rise and transformation of Bronze Age pastoralists in the Caucasus AI翻译
  作者：Ghalichi, Ayshin; Reinhold, Sabine; Rohrlach, Adam B.; Kalmykov, Alexey A.; Childebayeva, Ainash; Yu, He; Aron, Franziska; Semerau, Lena; Bastert-Lamprichs, Katrin; Belinskiy, Andrey B.; Berezina, Natalia Y.; Berezin, Yakov B.; Broomandkhoshbacht, Nasreen; Buzhilova, Alexandra P.; Erlikh, Vladimir R.; Fehren-Schmitz, Lars; Gambashidze, Irina; Kantorovich, Anatoliy R.; Kolesnichenko, Konstantin B.; Lordkipanidze, David; Magomedov, Rabadan G.; Malek-Custodis, Katharina; Mariaschk, Dirk; Maslov, Vladimir E.; Mkrtchyan, Levon; Nagler, Anatoli; Fazeli Nashli, Hassan; Ochir, Maria; Piotrovskiy, Yuri Y.; Saribekyan, Mariam; Sheremetev, Aleksandr G.; Stoellner, Thomas; Thomalsky, Judith; Vardanyan, Benik; Posth, Cosimo; Krause, Johannes; Warinner, Christina; Hansen, Svend; Haak, Wolfgang
  作者单位：Max Planck Society; University of Adelaide; University of Texas System; University of Texas Austin; Peking University; Lomonosov Moscow State University; Federal State Institution of Scientific Research Institute of the Federal Penitentiary Service of Russia; Lomonosov Moscow State University; University of California System; University of California Santa Cruz; University of California System; University of California Santa Cruz; Lomonosov Moscow State University; Ivane Javakhishvili Tbilisi State University; Russian Academy of Sciences; Russian Academy of Sciences; Institute of Archaeology, Russian Academy of Sciences; National Academy of Sciences of Armenia; Institute of Archaeology & Ethnography - NAS RA; University of Tehran; Kalmyk Scientific Center of the Russian Academy of Sciences; Russian Academy of Sciences; State Hermitage Museum; Ruhr University Bochum; Leibniz Association; Deutsches Bergbau Museum Bochum (DBM); National Academy of Sciences of Armenia; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); Friedrich Schiller University of Jena; Harvard University
  摘要：The Caucasus and surrounding areas, with their rich metal resources, became a crucible of the Bronze Age1 and the birthplace of the earliest steppe pastoralist societies2. Yet, despite this region having a large influence on the subsequent development of Europe and Asia, questions remain regarding its hunter-gatherer past and its formation of expansionist mobile steppe societies3-5. Here we present new genome-wide data for 131 individuals from 38 archaeological sites spanning 6,000 years. We f...
• Superconductivity researcher who committed misconduct exits university AI翻译
  作者：Garisto, Dan
  摘要：The University of Rochester has confirmed that it no longer employs Ranga Dias, who was found by investigators to have fabricated data.
• Transgelin 2 guards T cell lipid metabolism and antitumour function AI翻译
  作者：Hwang, Sung-Min; Awasthi, Deepika; Jeong, Jieun; Sandoval, Tito A.; Chae, Chang-Suk; Ramos, Yusibeska; Tan, Chen; Falco, Matias Marin; Salvagno, Camilla; Emmanuelli, Alexander; McBain, Ian T.; Mishra, Bikash; Ivashkiv, Lionel B.; Zamarin, Dmitriy; Cantillo, Evelyn; Chapman-Davis, Eloise; Holcomb, Kevin; Morales, Diana K.; Yu, Xiaoqing; Rodriguez, Paulo C.; Conejo-Garcia, Jose R.; Kaczocha, Martin; Vaharautio, Anna; Song, Minkyung; Cubillos-Ruiz, Juan R.
  作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; University of Helsinki; Cornell University; Icahn School of Medicine at Mount Sinai; H Lee Moffitt Cancer Center & Research Institute; Duke University; Duke University; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital; National Cancer Center - Korea (NCC); Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU)
  摘要：Mounting effective immunity against pathogens and tumours relies on the successful metabolic programming of Tcells by extracellular fatty acids(1-3). Fatty-acid-binding protein5 (FABP5) has a key role in this process by coordinating the efficient import and trafficking of lipids that fuel mitochondrial respiration to sustain the bioenergetic requirements of protective CD8(+) Tcells(4,5). However, the mechanisms that govern this immunometabolic axis remain unexplored. Here we report that the cy...
• One-shot entorhinal maps enable flexible navigation in novel environments AI翻译
  作者：Wen, John H.; Sorscher, Ben; Jones, Emily A. Aery; Ganguli, Surya; Giocomo, Lisa M.
  作者单位：Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute
  摘要：Animals must navigate changing environments to find food, shelter or mates. In mammals, grid cells in the medial entorhinal cortex construct a neural spatial map of the external environment1-5. However, how grid cell firing patterns rapidly adapt to novel or changing environmental features on a timescale relevant to behaviour remains unknown. Here, by recording over 15,000 grid cells in mice navigating virtual environments, we tracked the real-time state of the grid cell network. This allowed ...
• Local probe of bulk and edge states in a fractional Chern insulator AI翻译
  作者：Ji, Zhurun; Park, Heonjoon; Barber, Mark E.; Hu, Chaowei; Watanabe, Kenji; Taniguchi, Takashi; Chu, Jiun-Haw; Xu, Xiaodong; Shen, Zhi-Xun
  作者单位：Stanford University; Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; University of Washington; University of Washington Seattle; National Institute for Materials Science; National Institute for Materials Science; University of Washington; University of Washington Seattle; Stanford University
  摘要：The fractional quantum Hall effect is a key example of topological quantum many-body phenomena, arising from the interplay between strong electron correlation, topological order and time-reversal symmetry breaking. Recently, a lattice analogue of the fractional quantum Hall effect at zero magnetic field has been observed, confirming the existence of a zero-field fractional Chern insulator (FCI). Despite this, the bulk-edge correspondence-a hallmark of a FCI featuring an insulating bulk with co...
• Why it's in rich nations' interests to fund climate finance AI翻译
  作者：Kleinnijenhuis, Alissa M.
  作者单位：Cornell University; Imperial College London
• Photocatalytic low-temperature defluorination of PFASs AI翻译
  作者：Zhang, Hao; Chen, Jin-Xiang; Qu, Jian-Ping; Kang, Yan-Biao
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Nanjing Tech University
  摘要：Polyfluoroalkyl and perfluoroalkyl substances (PFASs) are found in many everyday consumer products, often because of their high thermal and chemical stabilities, as well as their hydrophobic and oleophobic properties1. However, the inert carbon-fluorine (C-F) bonds that give PFASs their properties also provide resistance to decomposition through defluorination, leading to long-term persistence in the environment, as well as in the human body, raising substantial safety and health concerns1-5. ...
• AKT and EZH2 inhibitors kill TNBCs by hijacking mechanisms of involution AI翻译
  作者：Schade, Amy E.; Perurena, Naiara; Yang, Yoona; Rodriguez, Carrie L.; Krishnan, Anjana; Gardner, Alycia; Loi, Patrick; Xu, Yilin; Nguyen, Van T. M.; Mastellone, G. M.; Pilla, Natalie F.; Watanabe, Marina; Ota, Keiichi; Davis, Rachel A.; Mattioli, Kaia; Xiang, Dongxi; Zoeller, Jason J.; Lin, Jia-Ren; Morganti, Stefania; Garrido-Castro, Ana C.; Tolaney, Sara M.; Li, Zhe; Barbie, David A.; Sorger, Peter K.; Helin, Kristian; Santagata, Sandro; Knott, Simon R. V.; Cichowski, Karen
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Cedars Sinai Medical Center; Cedars Sinai Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
  摘要：Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and has the highest rate of recurrence(1). The predominant standard of care for advanced TNBC is systemic chemotherapy with or without immunotherapy; however, responses are typically short lived(1,2). Thus, there is an urgent need to develop more effective treatments. Components of the PI3K pathway represent plausible therapeutic targets; more than 70% of TNBCs have alterations in PIK3CA, AKT1 or PTEN3-6. However...
• This scientist treated her own cancer with viruses she grew in the lab AI翻译
  作者：Corbyn, Zoe
  摘要：Virologist Beata Halassy says self-treatment worked and was a positive experience - but researchers warn that it is not something others should try.