-
作者：Fu, Wenyu; Vasylyev, Dmytro; Bi, Yufei; Zhang, Mingshuang; Sun, Guodong; Khleborodova, Asya; Huang, Guiwu; Zhao, Libo; Zhou, Renpeng; Li, Yonggang; Liu, Shujun; Cai, Xianyi; He, Wenjun; Cui, Min; Zhao, Xiangli; Hettinghouse, Aubryanna; Good, Julia; Kim, Ellen; Strauss, Eric; Leucht, Philipp; Schwarzkopf, Ran; Guo, Edward X.; Samuels, Jonathan; Hu, Wenhuo; Attur, Mukundan; Waxman, Stephen G.; Liu, Chuan-ju
作者单位：New York University; Yale University; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; Columbia University; New York University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; New York University
摘要：Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain(1). Although limited evidence suggests the existence of voltage-gated sodium channels (VGSCs) in chondrocytes(2), their expression and function in chondrocytes and in OA remain essentially unknown. Here we identify Na(v)1.7 as an OA-associated VGSC and demonstrate that human OA chondrocytes express functional Na(v)1.7 channels, with a den...
-
作者：Tamessar, Cottrell
作者单位：University of Newcastle; Hunter Medical Research Institute
-
作者：[Anonymous]
-
作者：Greene, Chad A.; Gardner, Alex S.; Wood, Michael; Cuzzone, Joshua K.
作者单位：California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Moss Landing Marine Laboratories; California State University System; San Jose State University; University of California System; University of California Los Angeles
摘要：Nearly every glacier in Greenland has thinned or retreated over the past few decades1-4, leading to glacier acceleration, increased rates of sea-level rise and climate impacts around the globe5-9. To understand how calving-front retreat has affected the ice-mass balance of Greenland, we combine 236,328 manually derived and AI-derived observations of glacier terminus positions collected from 1985 to 2022 and generate a 120-m-resolution mask defining the ice-sheet extent every month for nearly f...
-
作者：Gugger, Morgan K.; Hergenrother, Paul J.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign
-
作者：Witze, Alexandra
摘要：Astrobotic, the firm that launched the Peregrine spacecraft, says it will learn from any missteps and look ahead to its next attempt.
-
作者：[Anonymous]
-
作者：Pahil, Karanbir S.; Gilman, Morgan S. A.; Baidin, Vadim; Clairfeuille, Thomas; Mattei, Patrizio; Bieniossek, Christoph; Dey, Fabian; Muri, Dieter; Baettig, Remo; Lobritz, Michael; Bradley, Kenneth; Kruse, Andrew C.; Kahne, Daniel
作者单位：Harvard University; Harvard University; Harvard Medical School; Roche Holding; Roche Holding; Roche Holding
摘要：Gram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic membrane is surrounded by an outer membrane that blocks the entry of most antibiotics. The impenetrable nature of the outer membrane is due to the presence of a large, amphipathic glycolipid called lipopolysaccharide (LPS) in its outer leaflet1. Assembly of the outer membrane requires transport of LPS across a protein bridge that spans from the cytoplasmic membrane to the cell surface. Maintaining outer memb...
-
作者：Chen, Peng; Xiao, Yun; Hu, Juntao; Li, Shunde; Luo, Deying; Su, Rui; Caprioglio, Pietro; Kaienburg, Pascal; Jia, Xiaohan; Chen, Nan; Wu, Jingjing; Sui, Yanping; Tang, Pengyi; Yan, Haoming; Huang, Tianyu; Yu, Maotao; Li, Qiuyang; Zhao, Lichen; Hou, Cheng-Hung; You, Yun-Wen; Shyue, Jing-Jong; Wang, Dengke; Li, Xiaojun; Zhao, Qing; Gong, Qihuang; Lu, Zheng-Hong; Snaith, Henry J.; Zhu, Rui
作者单位：Peking University; Peking University; Tsinghua University; Collaborative Innovation Center of Quantum Matter; University of Oxford; Yunnan University; University of Toronto; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS; Academia Sinica - Taiwan; Chinese Academy of Sciences; Institute of Chemistry, CAS; Peking University; Shanxi University; Kunming Medical University
摘要：Perovskite solar cells (PSCs) comprise a solid perovskite absorber sandwiched between several layers of different charge-selective materials, ensuring unidirectional current flow and high voltage output of the devices1,2. A 'buffer material' between the electron-selective layer and the metal electrode in p-type/intrinsic/n-type (p-i-n) PSCs (also known as inverted PSCs) enables electrons to flow from the electron-selective layer to the electrode3-5. Furthermore, it acts as a barrier inhibiting...
-
作者：Conroy, Gemma
摘要：The 300-kilogram primate couldn't adapt when a changing environment forced a dietary shift.
