2024

最新文章

• Geophysical evidence for an enriched molten silicate layer above Mars's core (vol 622, pg 712, 2023) AI翻译
  作者：Samuel, Henri; Drilleau, Melanie; Rivoldini, Attilio; Xu, Zongbo; Huang, Quancheng; Garcia, Raphael F.; Lekic, Vedran; Irving, Jessica C. E.; Badro, James; Lognonne, Philippe H.; Connolly, James A. D.; Kawamura, Taichi; Gudkova, Tamara; Banerdt, William B.
• The demise of the giant ape Gigantopithecus blacki AI翻译
  作者：Zhang, Yingqi; Westaway, Kira E.; Haberle, Simon; Lubeek, Julien K.; Bailey, Marian; Ciochon, Russell; Morley, Mike W.; Roberts, Patrick; Zhao, Jian-xin; Duval, Mathieu; Dosseto, Anthony; Pan, Yue; Rule, Sue; Liao, Wei; Gully, Grant A.; Lucas, Mary; Mo, Jinyou; Yang, Liyun; Cai, Yanjun; Wang, Wei; Joannes-Boyau, Renaud
  作者单位：Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Macquarie University; Australian National University; Southern Cross University; University of Iowa; University of Iowa; Flinders University South Australia; Max Planck Society; Max Planck Society; University of Queensland; University of Queensland; Centro Nacional de Investigacion de La Evolucion Humana (CENIEH); Griffith University; University of Wollongong; Shandong University; Flinders University South Australia; Xi'an Jiaotong University; University of Johannesburg
  摘要：The largest ever primate and one of the largest of the southeast Asian megafauna, Gigantopithecus blacki1, persisted in China from about 2.0 million years until the late middle Pleistocene when it became extinct(2-4). Its demise is enigmatic considering that it was one of the few Asian great apes to go extinct in the last 2.6 million years, whereas others, including orangutan, survived until the present(5). The cause of the disappearance of G. blacki remains unresolved but could shed light on ...
• Stream-disk shocks as the origins of peak light in tidal disruption events AI翻译
  作者：Steinberg, Elad; Stone, Nicholas C.
  作者单位：Hebrew University of Jerusalem
  摘要：Tidal disruption events (TDEs) occur when stars are ripped apart1,2 by massive black holes and result in highly luminous, multi-wavelength flares3-5. Optical-ultraviolet observations5-7 of TDEs contradict simple models of TDE emission2,8, but the debate between alternative models (for example, shock power9,10 or reprocessed accretion power11-16) remains unsettled, as the dynamic range of the problem has so far prevented ab initio hydrodynamical simulations17. Consequently, past simulations hav...
• US particle physicists want to build a muon collider - Europe should pitch in AI翻译
  作者：[Anonymous]
  摘要：A feasibility study for a muon smasher in the United States could be an affordable way to maintain particle-physics unity.
• Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides AI翻译
  作者：Huang, Di; Zhu, Xiaofeng; Ye, Shuying; Zhang, Jiahui; Liao, Jianyou; Zhang, Ning; Zeng, Xin; Wang, Jiawen; Yang, Bing; Zhang, Yin; Lao, Liyan; Chen, Jianing; Xin, Min; Nie, Yan; Saw, Phei Er; Su, Shicheng; Song, Erwei
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
  摘要：Emerging data have shown that previously defined noncoding genomes might encode peptides that bind human leukocyte antigen (HLA) as cryptic antigens to stimulate adaptive immunity1,2. However, the significance and mechanisms of action of cryptic antigens in anti-tumour immunity remain unclear. Here mass spectrometry of the HLA class I (HLA-I) peptidome coupled with ribosome sequencing of human breast cancer samples identified HLA-I-binding cryptic antigenic peptides that were noncanonically tr...
• A novel antibiotic class targeting the lipopolysaccharide transporter AI翻译
  作者：Zampaloni, Claudia; Mattei, Patrizio; Bleicher, Konrad; Winther, Lotte; Thate, Claudia; Bucher, Christian; Adam, Jean-Michel; Alanine, Alexander; Amrein, Kurt E.; Baidin, Vadim; Bieniossek, Christoph; Bissantz, Caterina; Boess, Franziska; Cantrill, Carina; Clairfeuille, Thomas; Dey, Fabian; Di Giorgio, Patrick; du Castel, Pauline; Dylus, David; Dzygiel, Pawel; Felici, Antonio; Garcia-Alcalde, Fernando; Haldimann, Andreas; Leipner, Matthew; Leyn, Semen; Louvel, Severine; Misson, Pauline; Osterman, Andrei; Pahil, Karanbir; Rigo, Sebastien; Schaublin, Adrian; Scharf, Sebastian; Schmitz, Petra; Stoll, Theodor; Trauner, Andrej; Zoffmann, Sannah; Kahne, Daniel; Young, John A. T.; Lobritz, Michael A.; Bradley, Kenneth A.
  作者单位：Roche Holding; Roche Holding; Roche Holding; Johnson & Johnson; Janssen Pharmaceuticals; Johson & Johnson Belgium; Harvard University; Sanford Burnham Prebys Medical Discovery Institute; Roche Holding; Johnson & Johnson; Johson & Johnson Belgium; Janssen Pharmaceuticals
  摘要：Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options1. No new antibiotic chemical class with activity against A. baumannii has reached patients in over 50 years1. Here we report the identification and optimization of tethered macrocyclic peptide (MCP) antibiotics with potent antibacterial activity against CRAB. The mechanism of action of this molecule class involves blocking the transport of bacterial lipopolysaccharide from ...
• BCG: WHY PEOPLE'S IMMUNE RESPONSES TO VACCINE VARY AI翻译
  作者：[Anonymous]
• Ionized gas extends over 40 kpc in an odd radio circle host galaxy AI翻译
  作者：Coil, Alison L.; Perrotta, Serena; Rupke, David S. N.; Lochhaas, Cassandra; Tremonti, Christy A.; Diamond-Stanic, Aleks; Fielding, Drummond; Geach, James E.; Hickox, Ryan C.; Moustakas, John; Rudnick, Gregory H.; Sell, Paul; Whalen, Kelly E.
  作者单位：University of California System; University of California San Diego; Space Telescope Science Institute; University of Wisconsin System; University of Wisconsin Madison; Simons Foundation; Flatiron Institute; University of Hertfordshire; Dartmouth College; University of Kansas; State University System of Florida; University of Florida
  摘要：A new class of extragalactic astronomical sources discovered in 2021, named odd radio circles (ORCs)1, are large rings of faint, diffuse radio continuum emission spanning approximately 1 arcminute on the sky. Galaxies at the centres of several ORCs have photometric redshifts of z similar or equal to 0.3-0.6, implying physical scales of several 100 kpc in diameter for the radio emission, the origin of which is unknown. Here we report spectroscopic data on an ORC including strong [O ii] emission...
• Large language models help computer programs to evolve AI翻译
  作者：Mouret, Jean-Baptiste
  作者单位：Universite de Lorraine; Centre National de la Recherche Scientifique (CNRS)
  摘要：A branch of computer science known as genetic programming has been given a boost with the application of large language models that are trained on the combined intuition of the world's programmers.
• Why the immune response to a vaccine varies from person to person AI翻译
  作者：[Anonymous]
  摘要：A dormant immune system before receiving the BCG vaccine is tied to a greater innate immune response afterwards.