-
作者：Ward, Collin P.; Reddy, Christopher M.; Edwards, Brian; Perri, Steven T.
作者单位：Woods Hole Oceanographic Institution; Woods Hole Oceanographic Institution
-
作者：Willyard, Cassandra
-
作者：Witze, Alexandra
-
作者：Monticelli, Silvia; Cejka, Petr
作者单位：Universita della Svizzera Italiana
-
作者：Cao, Dongdong; Gao, Yunrong; Chen, Zhenhang; Gooneratne, Inesh; Roesler, Claire; Mera, Cristopher; D'Cunha, Paul; Antonova, Anna; Katta, Deepak; Romanelli, Sarah; Wang, Qi; Rice, Samantha; Lemons, Wesley; Ramanathan, Anita; Liang, Bo
作者单位：Emory University
摘要：The respiratory syncytial virus (RSV) polymerase is a multifunctional RNA-dependent RNA polymerase composed of the large (L) protein and the phosphoprotein (P). It transcribes the RNA genome into ten viral mRNAs and replicates full-length viral genomic and antigenomic RNAs1. The RSV polymerase initiates RNA synthesis by binding to the conserved 3 '-terminal RNA promoters of the genome or antigenome2. However, the lack of a structure of the RSV polymerase bound to the RNA promoter has impeded t...
-
作者：Melcer, Ron Aharon; Gil, Avigail; Paul, Arup Kumar; Tiwari, Priya; Umansky, Vladimir; Heiblum, Moty; Oreg, Yuval; Stern, Ady; Berg, Erez
作者单位：Weizmann Institute of Science; Weizmann Institute of Science
摘要：The quantum Hall effect is a prototypical realization of a topological state of matter. It emerges from a subtle interplay between topology, interactions and disorder1-9. The disorder enables the formation of localized states in the bulk that stabilize the quantum Hall states with respect to the magnetic field and carrier density3. Still, the details of the localized states and their contribution to transport remain beyond the reach of most experimental techniques10-31. Here we describe an ext...
-
作者：Devant, Pascal; Dong, Ying; Mintseris, Julian; Ma, Weiyi; Gygi, Steven P.; Wu, Hao; Kagan, Jonathan C.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Harvard Medical School
-
作者：Harvey, Alvin D.
作者单位：Massachusetts Institute of Technology (MIT)
-
作者：Klucznik, Tomasz; Syntrivanis, Leonidas-Dimitrios; Bas, Sebastian; Mikulak-Klucznik, Barbara; Moskal, Martyna; Szymkuc, Sara; Mlynarski, Jacek; Gadina, Louis; Beker, Wiktor; Burke, Martin D.; Tiefenbacher, Konrad; Grzybowski, Bartosz A.
作者单位：Polish Academy of Sciences; Institute of Organic Chemistry of the Polish Academy of Sciences; University of Illinois System; University of Illinois Urbana-Champaign; University of Basel; Jagiellonian University; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Swiss Federal Institutes of Technology Domain; ETH Zurich; Institute for Basic Science - Korea (IBS); Ulsan National Institute of Science & Technology (UNIST)
摘要：Recent years have seen revived interest in computer-assisted organic synthesis1,2. The use of reaction- and neural-network algorithms that can plan multistep synthetic pathways have revolutionized this field1,3-7, including examples leading to advanced natural products6,7. Such methods typically operate on full, literature-derived 'substrate(s)-to-product' reaction rules and cannot be easily extended to the analysis of reaction mechanisms. Here we show that computers equipped with a comprehens...
-
作者：Ogden, Lesley Evans
