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作者：Wirbel, Jakob; Bhatt, Ami S.; Probst, Alexander J.
作者单位：Stanford University; Stanford University
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作者：[Anonymous]
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作者：Torres, Susana Vazquez; Leung, Philip J. Y.; Venkatesh, Preetham; Lutz, Isaac D.; Hink, Fabian; Huynh, Huu-Hien; Becker, Jessica; Yeh, Andy Hsien-Wei; Juergens, David; Bennett, Nathaniel R.; Hoofnagle, Andrew N.; Huang, Eric; MacCoss, Michael J.; Exposit, Marc; Lee, Gyu Rie; Bera, Asim K.; Kang, Alex; De La Cruz, Joshmyn; Levine, Paul M.; Li, Xinting; Lamb, Mila; Gerben, Stacey R.; Murray, Analisa; Heine, Piper; Korkmaz, Elif Nihal; Nivala, Jeff; Stewart, Lance; Watson, Joseph L.; Rogers, Joseph M.; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Copenhagen; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
摘要：Many peptide hormones form an alpha-helix on binding their receptors1-4, and sensitive methods for their detection could contribute to better clinical management of disease5. De novo protein design can now generate binders with high affinity and specificity to structured proteins6,7. However, the design of interactions between proteins and short peptides with helical propensity is an unmet challenge. Here we describe parametric generation and deep learning-based methods for designing proteins ...
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作者：Jones, Nicola
摘要：Researchers are experimenting with different designs that could lower costs, extend vehicle ranges and offer other improvements.
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作者：Mylopotamitaki, Dorothea; Weiss, Marcel; Fewlass, Helen; Zavala, Elena Irene; Rougier, Helene; Suemer, Arev Pelin; Hajdinjak, Mateja; Smith, Geoff M.; Ruebens, Karen; Sinet-Mathiot, Virginie; Pederzani, Sarah; Essel, Elena; Harking, Florian S.; Xia, Huan; Hansen, Jakob; Kirchner, Andre; Lauer, Tobias; Stahlschmidt, Mareike; Hein, Michael; Talamo, Sahra; Wacker, Lukas; Meller, Harald; Dietl, Holger; Orschiedt, Joerg; Olsen, Jesper V.; Zeberg, Hugo; Pruefer, Kay; Krause, Johannes; Meyer, Matthias; Welker, Frido; Mcpherron, Shannon P.; Schueler, Tim; Hublin, Jean-Jacques
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; College de France; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Max Planck Society; University of Erlangen Nuremberg; Francis Crick Institute; University of California System; University of California Berkeley; California State University System; California State University Northridge; University of Kent; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Bordeaux; Universidad de la Laguna; University of Copenhagen; Lanzhou University; University of Copenhagen; Autonomous University of Barcelona; Eberhard Karls University of Tubingen; University of Vienna; Leuphana University Luneburg; Leipzig University; University of Bologna; Swiss Federal Institutes of Technology Domain; ETH Zurich; Karolinska Institutet
摘要：The Middle to Upper Palaeolithic transition in Europe is associated with the regional disappearance of Neanderthals and the spread of Homo sapiens. Late Neanderthals persisted in western Europe several millennia after the occurrence of H. sapiens in eastern Europe1. Local hybridization between the two groups occurred2, but not on all occasions3. Archaeological evidence also indicates the presence of several technocomplexes during this transition, complicating our understanding and the associat...
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作者：Tye, Simon P.; Fey, Samuel B.; Gibert, Jean P.; Siepielski, Adam M.
作者单位：University of Arkansas System; University of Arkansas Fayetteville; Reed College - Portland; Duke University
摘要：Predators have a key role in structuring ecosystems1-4. However, predator loss is accelerating globally4-6, and predator mass-mortality events7 (MMEs)-rapid large-scale die-offs-are now emblematic of the Anthropocene epoch6. Owing to their rare and unpredictable nature7, we lack an understanding of how MMEs immediately impact ecosystems. Past predator-removal studies2,3 may be insufficient to understand the ecological consequences of MMEs because, in nature, dead predators decompose in situ an...
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作者：Woodruff, Kelsey Alexandra; Termini, Christina Marie
作者单位：University of Washington; University of Washington Seattle
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作者：Cuk, Matija; Rhoden, Alyssa Rose
作者单位：SETI Institute; Southwest Research Institute
摘要：The shifting orbit of one of Saturn's moons indicates that the satellite has a subsurface ocean, contradicting theories that its interior is entirely solid. The finding calls for a fresh take on what constitutes an ocean moon.
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作者：Freitas, Florencio Porto; Alborzinia, Hamed; dos Santos, Ancely Ferreira; Nepachalovich, Palina; Pedrera, Lohans; Zilka, Omkar; Inague, Alex; Klein, Corinna; Aroua, Nesrine; Kaushal, Kamini; Kast, Bettina; Lorenz, Svenja M.; Kunz, Viktoria; Nehring, Helene; da Silva, Thamara N. Xavier; Chen, Zhiyi; Atici, Sena; Doll, Sebastian G.; Schaefer, Emily L.; Ekpo, Ifedapo; Schmitz, Werner; Horling, Aline; Imming, Peter; Miyamoto, Sayuri; Wehman, Ann M.; Genaro-Mattos, Thiago C.; Mirnics, Karoly; Kumar, Lokender; Klein-Seetharaman, Judith; Meierjohann, Svenja; Weigand, Isabel; Kroiss, Matthias; Bornkamm, Georg W.; Gomes, Fernando; Netto, Luis Eduardo Soares; Sathian, Manjima B.; Konrad, David B.; Covey, Douglas F.; Michalke, Bernhard; Bommert, Kurt; Bargou, Ralf C.; Garcia-Saez, Ana; Pratt, Derek A.; Fedorova, Maria; Trumpp, Andreas; Conrad, Marcus; Angeli, Jose Pedro Friedmann
作者单位：University of Wurzburg; Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz Association; German Cancer Research Center (DKFZ); Technische Universitat Dresden; Carl Gustav Carus University Hospital; Technische Universitat Dresden; University of Cologne; University of Ottawa; Universidade de Sao Paulo; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Wurzburg; University of Wurzburg; Martin Luther University Halle Wittenberg; University of Denver; University of Nebraska System; University of Nebraska Medical Center; Shoolini University; Colorado School of Mines; Arizona State University; Arizona State University-Downtown Phoenix; University of Wurzburg; University of Munich; Ulm University; Universidade de Sao Paulo; University of Munich; Washington University (WUSTL); Washington University (WUSTL); Helmholtz Association; German Cancer Research Center (DKFZ)
摘要：Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation1,2. Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC). Although previous studies suggested that high concen...
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作者：King, Jean
作者单位：Worcester Polytechnic Institute
摘要：Under-represented groups face chronic barriers, creating psychological - and physical - effects. The scientific community must ease this burden.
