8044期

最新文章

• Pharmacological restoration of GTP hydrolysis by mutant RAS AI翻译
  作者：Cuevas-Navarro, Antonio; Pourfarjam, Yasin; Hu, Feng; Rodriguez, Diego J.; Vides, Alberto; Sang, Ben; Fan, Shijie; Goldgur, Yehuda; de Stanchina, Elisa; Lito, Piro
  作者单位：Memorial Sloan Kettering Cancer Center; Rockefeller University; Cornell University; Weill Cornell Medicine; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
  摘要：Approximately 3.4 million patients worldwide are diagnosed each year with cancers that have pathogenic mutations in one of three RAS proto-oncogenes (KRAS, NRAS and HRAS)1,2. These mutations impair the GTPase activity of RAS, leading to activation of downstream signalling and proliferation3, 4, 5-6. Long-standing efforts to restore the hydrolase activity of RAS mutants have been unsuccessful, extinguishing any consideration towards a viable therapeutic strategy7. Here we show that tri-complex ...
• A pulsar-like polarization angle swing from a nearby fast radio burst AI翻译
  作者：Mckinven, Ryan; Bhardwaj, Mohit; Eftekhari, Tarraneh; Kilpatrick, Charles D.; Kirichenko, Aida; Pal, Arpan; Cook, Amanda M.; Gaensler, B. M.; Giri, Utkarsh; Kaspi, Victoria M.; Michilli, Daniele; Nimmo, Kenzie; Pearlman, Aaron B.; Pleunis, Ziggy; Sand, Ketan R.; Stairs, Ingrid; Andersen, Bridget C.; Andrew, Shion; Bandura, Kevin; Brar, Charanjot; Cassanelli, Tomas; Chatterjee, Shami; Curtin, Alice P.; Dong, Fengqiu Adam; Eadie, Gwendolyn; Fonseca, Emmanuel; Ibik, Adaeze L.; Kaczmarek, Jane F.; Kharel, Bikash; Lazda, Mattias; Leung, Calvin; Li, Dongzi; Main, Robert; Masui, Kiyoshi W.; Mena-Parra, Juan; Ng, Cherry; Pandhi, Ayush; Patil, Swarali Shivraj; Prochaska, J. Xavier; Rafiei-Ravandi, Masoud; Scholz, Paul; Shah, Vishwangi; Shin, Kaitlyn; Smith, Kendrick
  作者单位：McGill University; McGill University; Carnegie Mellon University; Northwestern University; Northwestern University; Universidad Nacional Autonoma de Mexico; Tata Institute of Fundamental Research (TIFR); National Centre for Radio Astrophysics (NCRA), Pune; University of Toronto; University of Toronto; University of California System; University of California Santa Cruz; University of Wisconsin System; University of Wisconsin Madison; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); University of Amsterdam; University of British Columbia; West Virginia University; Universidad de Chile; Cornell University; University of Toronto; University of Toronto; West Virginia University; Commonwealth Scientific & Industrial Research Organisation (CSIRO); University of California System; University of California Berkeley; Princeton University; Universite de Orleans; Centre National de la Recherche Scientifique (CNRS); University of California System; University of California Santa Cruz; University of Tokyo; National Institutes of Natural Sciences (NINS) - Japan; National Astronomical Observatory of Japan (NAOJ); York University - Canada; Perimeter Institute for Theoretical Physics
  摘要：Fast radio bursts (FRBs) last for milliseconds and arrive at Earth from cosmological distances. Although their origins and emission mechanisms are unknown, their signals bear similarities with the much less luminous radio emission generated by pulsars within our Miky Way Galaxy1, with properties suggesting neutron star origins2,3. However, unlike pulsars, FRBs typically show minimal variability in their linear polarization position angle (PA) curves4. Even when marked PA evolution is present, ...
• How to beat the biases harming women's mental health AI翻译
  作者：Chadha, Antonella Santuccione
• How Elon Musk's partnership with Trump could shape science in the US - and beyond AI翻译
  作者：Tollefson, Jeff
• Spatially restricted immune and microbiota-driven adaptation of the gut (dec, 10.1038/s41586-024-08216-z, 2024) AI翻译
  作者：Mayassi, Toufic; Li, Chenhao; Segerstolpe, Asa; Brown, Eric M.; Weisberg, Rebecca; Nakata, Toru; Yano, Hiroshi; Herbst, Paula; Artis, David; Graham, Daniel B.; Xavier, Ramnik J.
• Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson's disease could soon be here AI翻译
  作者：Abbott, Alison
• Endogenous self-peptides guard immune privilege of the central nervous system AI翻译
  作者：Kim, Min Woo; Gao, Wenqing; Lichti, Cheryl F.; Gu, Xingxing; Dykstra, Taitea; Cao, Jay; Smirnov, Igor; Boskovic, Pavle; Kleverov, Denis; Salvador, Andrea F. M.; Drieu, Antoine; Kim, Kyungdeok; Blackburn, Susan; Crewe, Clair; Artyomov, Maxim N.; Unanue, Emil R.; Kipnis, Jonathan
  作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); ITMO University; Washington University (WUSTL)
  摘要：Despite the presence of strategically positioned anatomical barriers designed to protect the central nervous system (CNS), it is not entirely isolated from the immune system1,2. In fact, it remains physically connected to, and can be influenced by, the peripheral immune system1. How the CNS retains such responsiveness while maintaining an immunologically unique status remains an outstanding question. Here, in searching for molecular cues that derive from the CNS and enable its direct communica...
• GaAs nano-ridge laser diodes fully fabricated in a 300-mm CMOS pilot line AI翻译
  作者：De Koninck, Yannick; Caer, Charles; Yudistira, Didit; Baryshnikova, Marina; Sar, Huseyin; Hsieh, Ping-Yi; Oezdemir, Cenk Ibrahim; Patra, Saroj Kanta; Kuznetsova, Nadezda; Colucci, Davide; Milenin, Alexey; Yimam, Andualem Ali; Morthier, Geert; Van Thourhout, Dries; Verheyen, Peter; Pantouvaki, Marianna; Kunert, Bernardette; Van Campenhout, Joris
  作者单位：Interuniversity Microelectronics Centre; KU Leuven; Ghent University; Interuniversity Microelectronics Centre; Swiss Center for Electronics & Microtechnology (CSEM); Infinera Corporation
  摘要：Silicon photonics is a rapidly developing technology that promises to revolutionize the way we communicate, compute and sense the world1, 2, 3, 4, 5-6. However, the lack of highly scalable, native complementary metal-oxide-semiconductor (CMOS)-integrated light sources is one of the main factors hampering its widespread adoption. Despite considerable progress in hybrid and heterogeneous integration of III-V light sources on silicon7, 8, 9, 10, 11-12, monolithic integration by direct epitaxy of ...
• The small-drone revolution is coming - scientists need to ensure it will be safe AI翻译
  作者：Huang, Xun
  作者单位：Peking University; Hong Kong University of Science & Technology
• Upconverting microgauges reveal intraluminal force dynamics in vivo AI翻译
  作者：Casar, Jason R.; Mclellan, Claire A.; Shi, Cindy; Stiber, Ariel; Lay, Alice; Siefe, Chris; Parakh, Abhinav; Gaerlan, Malaya; Gu, X. Wendy; Goodman, Miriam B.; Dionne, Jennifer A.
  作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Stanford University; Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
  摘要：The forces generated by action potentials in muscle cells shuttle blood, food and waste products throughout the luminal structures of the body. Although non-invasive electrophysiological techniques exist1, 2-3, most mechanosensors cannot access luminal structures non-invasively4, 5-6. Here we introduce non-toxic ingestible mechanosensors to enable the quantitative study of luminal forces and apply them to study feeding in living Caenorhabditis elegans roundworms. These optical 'microgauges' co...