8044期

最新文章

• Offline ensemble co-reactivation links memories across days AI翻译
  作者：Zaki, Yosif; Pennington, Zachary T.; Morales-Rodriguez, Denisse; Bacon, Madeline E.; Ko, BumJin; Francisco, Taylor R.; LaBanca, Alexa R.; Sompolpong, Patlapa; Dong, Zhe; Lamsifer, Sophia; Chen, Hung-Tu; Segura, Simon Carrillo; Wick, Zoe Christenson; Silva, Alcino J.; Rajan, Kanaka; van der Meer, Matthijs; Fenton, Andre; Shuman, Tristan; Cai, Denise J.
  作者单位：Icahn School of Medicine at Mount Sinai; Dartmouth College; New York University; New York University Tandon School of Engineering; University of California System; University of California Los Angeles; New York University; NYU Langone Medical Center
  摘要：Memories are encoded in neural ensembles during learning1-6 and are stabilized by post-learning reactivation7-17. Integrating recent experiences into existing memories ensures that memories contain the most recently available information, but how the brain accomplishes this critical process remains unclear. Here we show that in mice, a strong aversive experience drives offline ensemble reactivation of not only the recent aversive memory but also a neutral memory formed 2 days before, linking f...
• Natural History of Silence AI翻译
  作者：Soliman, Alix
• Apply the legal 'true malice' principle to protect research-misconduct sleuths AI翻译
  作者：Tang, Gengyan
  作者单位：University of Calgary
• Synthetic GPCRs for programmable sensing and control of cell behaviour AI翻译
  作者：Kalogriopoulos, Nicholas A.; Tei, Reika; Yan, Yuqi; Klein, Peter M.; Ravalin, Matthew; Cai, Bo; Soltesz, Ivan; Li, Yulong; Ting, Alice
  作者单位：Stanford University; Peking University; Stanford University; Peking University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI); Stanford University
  摘要：Synthetic receptors that mediate antigen-dependent cell responses are transforming therapeutics, drug discovery and basic research1,2. However, established technologies such as chimeric antigen receptors3 can only detect immobilized antigens, have limited output scope and lack built-in drug control3, 4, 5, 6-7. Here we engineer synthetic G-protein-coupled receptors (GPCRs) that are capable of driving a wide range of native or non-native cellular processes in response to a user-defined antigen....
• RANK drives structured intestinal epithelial expansion during pregnancy AI翻译
  作者：Onji, Masahiro; Sigl, Verena; Lendl, Thomas; Novatchkova, Maria; Ullate-Agote, Asier; Andersson-Rolf, Amanda; Kozieradzki, Ivona; Koglgruber, Rubina; Pai, Tsung-Pin; Lichtscheidl, Dominic; Nayak, Komal; Zilbauer, Matthias; Garcia, Natalia A. Carranza; Sievers, Laura Katharina; Falk-Paulsen, Maren; Cronin, Shane J. F.; Hagelkruys, Astrid; Sawa, Shinichiro; Osborne, Lisa C.; Rosenstiel, Philip; Pasparakis, Manolis; Ruland, Juergen; Takayanagi, Hiroshi; Clevers, Hans; Koo, Bon-Kyoung; Penninger, Josef M.
  作者单位：Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); Austrian Academy of Sciences; Medical University of Vienna; Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); University of Navarra; Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW); Utrecht University; Utrecht University Medical Center; University of British Columbia; University of Cambridge; University of Cambridge; University of British Columbia; University of Kiel; Schleswig Holstein University Hospital; University of Kiel; Schleswig Holstein University Hospital; Kyushu University; University of Cologne; University of Cologne; University of Tokyo; University of Tokyo; Princess Maxima Center; Institute for Basic Science - Korea (IBS); Helmholtz Association; Helmholtz-Center for Infection Research; Roche Holding
  摘要：During reproduction, multiple species such as insects and all mammals undergo extensive physiological and morphological adaptions to ensure health and survival of the mother and optimal development of the offspring. Here we report that the intestinal epithelium undergoes expansion during pregnancy and lactation in mammals. This enlargement of the intestinal surface area results in a novel geometry of expanded villi. Receptor activator of nuclear factor-kappa Beta (RANK, encoded by TNFRSF11A) a...
• Human HDAC6 senses valine abundancy to regulate DNA damage AI翻译
  作者：Jin, Jiali; Meng, Tong; Yu, Yuanyuan; Wu, Shuheng; Jiao, Chen-Chen; Song, Sihui; Li, Ya-Xu; Zhang, Yu; Zhao, Yuan-Yuan; Li, Xinran; Wang, Zixin; Liu, Yu-Fan; Huang, Runzhi; Qin, Jieling; Chen, Yihua; Cao, Hao; Tan, Xiao; Ge, Xin; Jiang, Cong; Xue, Jianhuang; Yuan, Jian; Wu, Dianqing; Wu, Wei; Jiang, Ci-Zhong; Wang, Ping
  作者单位：Tongji University; Shanghai Jiao Tong University; Tongji University; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Tongji University; East China Normal University; Kunming Medical University; Kunming Medical University; Kunming Medical University; Shenyang Pharmaceutical University; Tongji University; Yale University
  摘要：As an essential branched amino acid, valine is pivotal for protein synthesis, neurological behaviour, haematopoiesis and leukaemia progression1, 2-3. However, the mechanism by which cellular valine abundancy is sensed for subsequent cellular functions remains undefined. Here we identify that human histone deacetylase 6 (HDAC6) serves as a valine sensor by directly binding valine through a primate-specific SE14 repeat domain. The nucleus and cytoplasm shuttling of human, but not mouse, HDAC6 is...
• Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation AI翻译
  作者：Craven, Gregory B.; Chu, Hang; Sun, Jessica D.; Carelli, Jordan D.; Coyne, Brittany; Chen, Hao; Chen, Ying; Ma, Xiaolei; Das, Subhamoy; Kong, Wayne; Zajdlik, Adam D.; Yang, Kin S.; Reisberg, Solomon H.; Thompson, Peter A.; Lipford, J. Russell; Taunton, Jack
  作者单位：University of California System; University of California San Francisco
  摘要：Somatic alterations in the oncogenic kinase AKT1 have been identified in a broad spectrum of solid tumours. The most common AKT1 alteration replaces Glu17 with Lys (E17K) in the regulatory pleckstrin homology domain1, resulting in constitutive membrane localization and activation of oncogenic signalling. In clinical studies, pan-AKT inhibitors have been found to cause dose-limiting hyperglycaemia2-6, which has motivated the search for mutant-selective inhibitors. We exploited the E17K mutation...
• The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy AI翻译
  作者：Bornes, Laura; van Winden, Lennart J.; Geurts, Veerle C. M.; de Bruijn, Beaunelle; Azarang, Leyla; Lanfermeijer, Mirthe; Caruso, Marika; Proost, Natalie; Boeije, Manon; Lohuis, Jeroen O.; Belthier, Guillaume; Delgado, Eulalia Noguera; de Gruil, Nadia; Kroep, Judith R.; van de Ven, Marieke; Menezes, Renee; Wesseling, Jelle; Kok, Marleen; Linn, Sabine; Broeks, Annegien; van Rossum, Huub H.; Scheele, Colinda L. G. J.; van Rheenen, Jacco
  作者单位：Netherlands Cancer Institute; Netherlands Cancer Institute; Netherlands Cancer Institute; Flanders Institute for Biotechnology (VIB); KU Leuven; Netherlands Cancer Institute; Netherlands Cancer Institute; Netherlands Cancer Institute; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; Netherlands Cancer Institute; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Netherlands Cancer Institute; Utrecht University; Netherlands Cancer Institute
  摘要：The response of breast cancer to neoadjuvant chemotherapy (NAC) varies substantially, even when tumours belong to the same molecular or histological subtype1. Here we identify the oestrous cycle as an important contributor to this heterogeneity. In three mouse models of breast cancer, we show reduced responses to NAC when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus stage. Similar findings were observed in retrospective premenopausal cohor...
• Chinese rice actually tastes ever more nice AI翻译
  作者：Lu, Lin; Hu, Xianqiao; Chen, Mingxue; Hu, Peisong
  作者单位：Chinese Academy of Agricultural Sciences; China National Rice Research Institute, CAAS
• Fibular reduction and the evolution of theropod locomotion AI翻译
  作者：Manafzadeh, Armita R.; Gatesy, Stephen M.; Nyakatura, John A.; Bhullar, Bhart-Anjan S.
  作者单位：Yale University; Yale University; Yale University; Brown University; Humboldt University of Berlin
  摘要：Since Hamp & eacute;'s classic developmental experiments in the mid-twentieth century1,2, the reduced avian fibula has sparked sustained curiosity3-6. The fibula transformed throughout dinosaur evolution from a columnar structure into its splint-like avian form, a change long thought to be of little biomechanical consequence3,6. Here we integrated comparative three-dimensional kinematic analyses with transitional morphologies from the fossil record to refute this assumption and show that the r...