8048期

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• Martin Karplus (1930-2024) AI翻译
  作者：Mackerell, Alex
  作者单位：University System of Maryland; University of Maryland Baltimore
• Synaptic basis of feature selectivity in hippocampal neurons AI翻译
  作者：Gonzalez, Kevin C.; Negrean, Adrian; Liao, Zhenrui; Terada, Satoshi; Zhang, Guofeng; Lee, Sungmoo; Ocsai, Katalin; Rozsa, Balazs J.; Lin, Michael Z.; Polleux, Franck; Losonczy, Attila
  作者单位：Columbia University; Columbia University; Stanford University; Budapest University of Technology & Economics; HUN-REN; HUN-REN Institute of Experimental Medicine; Pazmany Peter Catholic University; Stanford University; Allen Institute for Brain Science; Sun Yat Sen University
  摘要：A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals1. Hippocampal CA1 pyramidal neurons display one of the most striking forms of feature selectivity by forming spatially and contextually selective receptive fields called place fields, which serve as a model for studying the synaptic basis of learning and memory. Various forms of synaptic plasticity have been proposed as cellular substrates for the emergence of place field...
• Evolution of myeloid-mediated immunotherapy resistance in prostate cancer AI翻译
  作者：Lyu, Aram; Fan, Zenghua; Clark, Matthew; Lea, Averey; Luong, Diamond; Setayesh, Ali; Starzinski, Alec; Wolters, Rachel; Arias-Badia, Marcel; Allaire, Kate; Wu, Kai; Gurunathan, Vibha; Valderrabano, Laura; Wei, Xiao X.; Miller, Richard A.; Van Allen, Eliezer M.; Fong, Lawrence
  作者单位：University of California System; University of California San Francisco; Fred Hutchinson Cancer Center; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center
  摘要：Patients with advanced metastatic castration-resistant prostate cancer (mCRPC) are refractory to immune checkpoint inhibitors (ICIs)1,2, partly because there are immunosuppressive myeloid cells in tumours3,4. However, the heterogeneity of myeloid cells has made them difficult to target, making blockade of the colony stimulating factor-1 receptor (CSF1R) clinically ineffective. Here we use single-cell profiling on patient biopsies across the disease continuum and find that a distinct population...
• Methane emissions from the Nord Stream subsea pipeline leaks AI翻译
  作者：Harris, Stephen J.; Schwietzke, Stefan; France, James L.; Velandia Salinas, Nataly; Meixus Fernandez, Tania; Randles, Cynthia; Guanter, Luis; Irakulis-Loitxate, Itziar; Calcan, Andreea; Aben, Ilse; Abrahamsson, Katarina; Balcombe, Paul; Berchet, Antoine; Biddle, Louise C.; Bittig, Henry C.; Boettcher, Christian; Bouvard, Timo; Brostroem, Goeran; Bruch, Valentin; Cassiani, Massimo; Chipperfield, Martyn P.; Ciais, Philippe; Damm, Ellen; Dammers, Enrico; Denier van der Gon, Hugo; Dogniaux, Matthieu; Dowd, Emily; Dupouy, Francois; Eckhardt, Sabine; Evangeliou, Nikolaos; Feng, Wuhu; Jia, Mengwei; Jiang, Fei; Kaiser-Weiss, Andrea K.; Kamoun, Ines; Kerridge, Brian J.; Lampert, Astrid; Lana, Jose; Li, Fei; Maasakkers, Joannes D.; Maclean, Jean-Philippe W.; Mamtimin, Buhalqem; Marshall, Julia; Mauger, Gedeon; Mekkas, Anouar; Mielke, Christian; Mohrmann, Martin; Moore, David P.; Nanni, Riccardo; Paetzold, Falk; Pison, Isabelle; Pisso, Ignacio; Platt, Stephen M.; Prea, Raphael; Queste, Bastien Y.; Ramonet, Michel; Rehder, Gregor; Remedios, John J.; Reum, Friedemann; Roiger, Anke; Schmidbauer, Norbert; Siddans, Richard; Sunkisala, Anusha; Thompson, Rona L.; Varon, Daniel J.; Ventress, Lucy J.; Wilson, Chris; Zhang, Yuzhong
  作者单位：University of London; Royal Holloway University London; Universitat Politecnica de Valencia; Vrije Universiteit Amsterdam; University of Gothenburg; University of London; Queen Mary University London; Universite Paris Saclay; CEA; Leibniz Institut fur Ostseeforschung Warnemunde; Universite Paris Saclay; CEA; NILU; University of Leeds; University of Leeds; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Netherlands Organization Applied Science Research; University of Leeds; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC National Centre for Atmospheric Science; Nanjing University; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; Braunschweig University of Technology; Helmholtz Association; German Aerospace Centre (DLR); University of Leicester; University of Leicester; Harvard University; Westlake University
  摘要：The amount of methane released to the atmosphere from the Nord Stream subsea pipeline leaks remains uncertain, as reflected in a wide range of estimates1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17-18. A lack of information regarding the temporal variation in atmospheric emissions has made it challenging to reconcile pipeline volumetric (bottom-up) estimates1, 2, 3, 4, 5, 6, 7-8 with measurement-based (top-down) estimates8, 9, 10, 11, 12, 13, 14, 15, 16, 17-18. Here we simulate pip...
• Determining structures of RNA conformers using AFM and deep neural networks AI翻译
  作者：Degenhardt, Maximilia F. S.; Degenhardt, Hermann F.; Bhandari, Yuba R.; Lee, Yun-Tzai; Ding, Jienyu; Yu, Ping; Heinz, William F.; Stagno, Jason R.; Schwieters, Charles D.; Watts, Norman R.; Wingfield, Paul T.; Rein, Alan; Zhang, Jinwei; Wang, Yun-Xing
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
  摘要：Much of the human genome is transcribed into RNAs1, many of which contain structural elements that are important for their function. Such RNA molecules-including those that are structured and well-folded2-are conformationally heterogeneous and flexible, which is a prerequisite for function3,4, but this limits the applicability of methods such as NMR, crystallography and cryo-electron microscopy for structure elucidation. Moreover, owing to the lack of a large RNA structure database, and no cle...
• Why fires spread quickly in modern cities - and how to slow them down AI翻译
  作者：Witze, Alexandra
• 'Stamp out paper mills' - science sleuths on how to fight fake research AI翻译
  作者：Abalkina, Anna; Aquarius, Rene; Bik, Elisabeth; Bimler, David; Bishop, Dorothy; Byrne, Jennifer; Cabanac, Guillaume; Day, Adam; Labbe, Cyril; Wise, Nick
  作者单位：Free University of Berlin; Radboud University Nijmegen; University of Oxford; University of Sydney; Universite de Toulouse; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Taylor & Francis; University of Cambridge
• The Human Cell Atlas from a cell census to a unified foundation model AI翻译
  作者：Rood, Jennifer E.; Wynne, Samantha; Robson, Lucia; Hupalowska, Anna; Randell, John; Teichmann, Sarah A.; Regev, Aviv
  作者单位：Roche Holding; Genentech; Roche Holding USA; University of Cambridge
  摘要：With the convergence of notable advances in molecular and spatial profiling methods and new computational approaches taking advantage of artificial intelligence and machine learning, the construction of cell atlases is progressing from data collection to atlas integration and beyond. Here, we explore five ways in which cell atlases, including the Human Cell Atlas, are already revealing valuable biological insights, and how they are poised to provide even greater benefits in the coming years. I...
• ' HOW 'DARK PROTEINS ARE CHANGING OUR UNDERSTANDING OF THE HUMAN GENOME AI翻译
  作者：Callaway, Ewen
• Native DGC structure rationalizes muscular dystrophy-causing mutations AI翻译
  作者：Liu, Shiheng; Su, Tiantian; Xia, Xian; Zhou, Z. Hong
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder marked by progressive muscle wasting leading to premature mortality1,2. Discovery of the DMD gene encoding dystrophin both revealed the cause of DMD and helped identify a family of at least ten dystrophin-associated proteins at the muscle cell membrane, collectively forming the dystrophin-glycoprotein complex (DGC)3, 4, 5, 6, 7, 8-9. The DGC links the extracellular matrix to the cytoskeleton, but, despite its importance,...