8048期

最新文章

• Sleep microstructure organizes memory replay AI翻译
  作者：Chang, Hongyu; Tang, Wenbo; Wulf, Annabella M.; Nyasulu, Thokozile; Wolf, Madison E.; Fernandez-Ruiz, Antonio; Oliva, Azahara
  作者单位：Cornell University
  摘要：Recently acquired memories are reactivated in the hippocampus during sleep, an initial step for their consolidation1, 2-3. This process is concomitant with the hippocampal reactivation of previous memories4, 5-6, posing the problem of how to prevent interference between older and recent, initially labile, memory traces. Theoretical work has suggested that consolidating multiple memories while minimizing interference can be achieved by randomly interleaving their reactivation7, 8, 9-10. An alte...
• Monoallelic expression can govern penetrance of inborn errors of immunity AI翻译
  作者：Stewart, O'Jay; Gruber, Conor; Randolph, Haley E.; Patel, Roosheel; Ramba, Meredith; Calzoni, Enrica; Huang, Lei Haley; Levy, Jay; Buta, Sofija; Lee, Angelica; Sazeides, Christos; Prue, Zoe; van Konijnenburg, David P. Hoytema; Chinn, Ivan K.; Pedroza, Luis A.; Lupski, James R.; Schmitt, Erica G.; Cooper, Megan A.; Puel, Anne; Peng, Xiao; Boisson-Dupuis, Stephanie; Bustamante, Jacinta; Okada, Satoshi; Martin-Fernandez, Marta; Orange, Jordan S.; Casanova, Jean-Laurent; Milner, Joshua D.; Bogunovic, Dusan
  作者单位：Columbia University; Columbia University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Columbia University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Harvard University; Harvard Medical School; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine; St. Louis Children's Hospital; Washington University (WUSTL); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Johns Hopkins University; Rockefeller University; Hiroshima University; Instituto de Salud Carlos III; Instituto de Investigacion de Enfermedades Raras (IIER); Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP
  摘要：Inborn errors of immunity (IEIs) are genetic disorders that underlie susceptibility to infection, autoimmunity, autoinflammation, allergy and/or malignancy1. Incomplete penetrance is common among IEIs despite their monogenic basis2. Here we investigate the contribution of autosomal random monoallelic expression (aRMAE), a somatic commitment to the expression of one allele3,4, to phenotypic variability observed in families with IEIs. Using a clonal primary T cell system to assess aRMAE status o...
• Liver X receptor unlinks intestinal regeneration and tumorigenesis AI翻译
  作者：Das, Srustidhar; Parigi, S. Martina; Luo, Xinxin; Fransson, Jennifer; Kern, Bianca C.; Okhovat, Ali; Diaz, Oscar E.; Sorini, Chiara; Czarnewski, Paulo; Webb, Anna T.; Morales, Rodrigo A.; Lebon, Sacha; Monasterio, Gustavo; Castillo, Francisca; Tripathi, Kumar P.; He, Ning; Pelczar, Penelope; Schaltenberg, Nicola; De la Fuente, Marjorie; Lopez-Kostner, Francisco; Nylen, Susanne; Larsen, Hjalte List; Kuiper, Raoul; Antonson, Per; Hermoso, Marcela A.; Huber, Samuel; Biton, Moshe; Scharaw, Sandra; Gustafsson, Jan-Ake; Katajisto, Pekka; Villablanca, Eduardo J.
  作者单位：Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; Stockholm University; Karolinska Institutet; Weizmann Institute of Science; University of Hamburg; University Medical Center Hamburg-Eppendorf; Universidad Finis Terrae; Clinica Las Condes; Universidad de Chile; Universidad de los Andes - Chile; Karolinska Institutet; University of Copenhagen; Norwegian Veterinary Institute; Karolinska Institutet; Karolinska Institutet; University of Houston System; University of Houston; University of Helsinki; Karolinska Institutet; Karolinska University Hospital; Rockefeller University; Max Planck Society
  摘要：Uncontrolled regeneration leads to neoplastic transformation1-3. The intestinal epithelium requires precise regulation during continuous homeostatic and damage-induced tissue renewal to prevent neoplastic transformation, suggesting that pathways unlinking tumour growth from regenerative processes must exist. Here, by mining RNA-sequencing datasets from two intestinal damage models4,5 and using pharmacological, transcriptomics and genetic tools, we identified liver X receptor (LXR) pathway acti...
• Dipoles disordered by design to increase capacity of energy-storage devices AI翻译
  作者：Behera, Piush; Cheema, Suraj S.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
• Electric Dreams: Art and Technology Before the Internet AI翻译
  作者：Sreevatsan, Ajai
• The surprising link between muscle and the reproductive system AI翻译
  作者：[Anonymous]
• How a boy from the Bronx unearthed the workings of the Universe AI翻译
  作者：Farmelo, Graham
  作者单位：University of Cambridge
• Obesity drugs: huge study identifies new health risks AI翻译
  作者：Guglielmi, Giorgia
• How I find and explain plant fossils in Romania AI翻译
  作者：Ro, Christine
• Global 3D model of mantle attenuation using seismic normal modes AI翻译
  作者：Talavera-Soza, Sujania; Cobden, Laura; Faul, Ulrich H.; Deuss, Arwen
  作者单位：Utrecht University; Massachusetts Institute of Technology (MIT); Vassar College
  摘要：Seismic tomographic models based only on wave velocities have limited ability to distinguish between a thermal or compositional origin for Earth's 3D structure1. Complementing wave velocities with attenuation observations can make that distinction, which is fundamental for understanding mantle convection evolution. However, global 3D attenuation models are only available for the upper mantle at present2, 3, 4-5. Here we present a 3D global model of attenuation for the whole mantle made using w...