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作者：Jin, Kelly; Yao, Zizhen; van Velthoven, Cindy T. J.; Kaplan, Eitan S.; Glattfelder, Katie; Barlow, Samuel T.; Boyer, Gabriella; Carey, Daniel; Casper, Tamara; Chakka, Anish Bhaswanth; Chakrabarty, Rushil; Clark, Michael; Departee, Max; Desierto, Marie; Gary, Amanda; Gloe, Jessica; Goldy, Jeff; Guilford, Nathan; Guzman, Junitta; Hirschstein, Daniel; Lee, Changkyu; Liang, Elizabeth; Pham, Trangthanh; Reding, Melissa; Ronellenfitch, Kara; Ruiz, Augustin; Sevigny, Josh; Shapovalova, Nadiya; Shulga, Lyudmila; Sulc, Josef; Torkelson, Amy; Tung, Herman; Levi, Boaz; Sunkin, Susan M.; Dee, Nick; Esposito, Luke; Smith, Kimberly A.; Tasic, Bosiljka; Zeng, Hongkui
作者单位：Allen Institute for Brain Science
摘要：Biological ageing can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function(1,2). Mammalian brains consist of thousands of cell types(3), which may be differentially susceptible or resilient to ageing. Here we present a comprehensive single-cell RNA sequencing dataset containing roughly 1.2million high-quality single-cell transcriptomes of brain cells from young adult and aged mice of both sexes, from regions spanning the forebrain, midbrain and ...
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作者：Furuhashi, Kazuhiro; Kakiuchi, Miwako; Ueda, Ryosuke; Oda, Hiroko; Ummarino, Simone; Ebralidze, Alexander K.; Bassal, Mahmoud A.; Meng, Chen; Sato, Tatsuyuki; Lyu, Jing; Han, Min-guk; Maruyama, Shoichi; Watanabe, Yu; Sawa, Yuriko; Kato, Daisuke; Wake, Hiroaki; Reizis, Boris; Frangos, John A.; Owens, David M.; Tenen, Daniel G.; Ghiran, Ionita C.; Robson, Simon C.; Fujisaki, Joji
作者单位：Columbia University; Columbia University; Nagoya University; Nagoya University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; National University of Singapore; Hubei University of Medicine; Nagoya University; New York University; La Jolla Bioengineering Institute; Columbia University; NewYork-Presbyterian Hospital; NewYork-Presbyterian Hospital; Columbia University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School
摘要：Stem cells reside in specialized microenvironments, termed niches, at several different locations in tissues(1, 2-3). The differential functions of heterogeneous stem cells and niches are important given the increasing clinical applications of stem-cell transplantation and immunotherapy. Whether hierarchical structures among stem cells at distinct niches exist and further control aspects of immune tolerance is unknown. Here we describe previously unknown new hierarchical arrangements in haemat...
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作者：Xu, Congling; Li, Chengyu; Chen, Jiwei; Xiong, Yan; Qiao, Zhibin; Fan, Pengyu; Li, Conghui; Ma, Shuangyu; Liu, Jin; Song, Aixia; Tao, Bolin; Xu, Tao; Xu, Wei; Chi, Yayun; Xue, Jingyan; Wang, Pu; Ye, Dan; Gu, Hongzhou; Zhang, Peng; Wang, Qiong; Xiao, Ruijing; Cheng, Jingdong; Zheng, Hai; Yu, Xiaoli; Zhang, Zhen; Wu, Jiong; Liang, Kaiwei; Liu, Yan-Jun; Lu, Huasong; Chen, Fei Xavier
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作者：Nobori, Tatsuya; Monell, Alexander; Lee, Travis A.; Sakata, Yuka; Shirahama, Shoma; Zhou, Jingtian; Nery, Joseph R.; Mine, Akira; Ecker, Joseph R.
作者单位：Salk Institute; Salk Institute; Howard Hughes Medical Institute; Salk Institute; University of California System; University of California San Diego; Kyoto University; University of East Anglia; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center
摘要：Plants lack specialized and mobile immune cells. Consequently, any cell type that encounters pathogens must mount immune responses and communicate with surrounding cells for successful defence. However, the diversity, spatial organization and function of cellular immune states in pathogen-infected plants are poorly understood(1). Here we infect Arabidopsis thaliana leaves with bacterial pathogens that trigger or supress immune responses and integrate time-resolved single-cell transcriptomic, e...
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作者：Park, R. S.; Jacobson, R. A.; Casajus, L. Gomez; Nimmo, F.; Ermakov, A. I.; Keane, J. T.; McKinnon, W. B.; Stevenson, D. J.; Akiba, R.; Idini, B.; Buccino, D. R.; Magnanini, A.; Parisi, M.; Tortora, P.; Zannoni, M.; Mura, A.; Durante, D.; Iess, L.; Connerney, J. E. P.; Levin, S. M.; Bolton, S. J.
作者单位：California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); University of Bologna; University of California System; University of California Santa Cruz; Stanford University; Washington University (WUSTL); California Institute of Technology; University of Bologna; Istituto Nazionale Astrofisica (INAF); Sapienza University Rome; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; Southwest Research Institute
摘要：Io experiences tidal deformation as a result of its eccentric orbit around Jupiter, which provides a primary energy source for Io's continuing volcanic activity and infrared emission(1). The amount of tidal energy dissipated within Io is enormous and has been suggested to support the large-scale melting of its interior and the formation of a global subsurface magma ocean. If Io has a shallow global magma ocean, its tidal deformation would be much larger than in the case of a more rigid, mostly...
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作者：Sun, Eric D.; Zhou, Olivia Y.; Hauptschein, Max; Rappoport, Nimrod; Xu, Lucy; Navarro Negredo, Paloma; Liu, Ling; Rando, Thomas A.; Zou, James; Brunet, Anne
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Stanford University; Stanford University; Stanford University
摘要：Old age is associated with a decline in cognitive function and an increase in neurodegenerative disease risk(1). Brain ageing is complex and is accompanied by many cellular changes(2). Furthermore, the influence that aged cells have on neighbouring cells and how this contributes to tissue decline is unknown. More generally, the tools to systematically address this question in ageing tissues have not yet been developed. Here we generate a spatially resolved single-cell transcriptomics brain atl...
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作者：Carroll, Sean
作者单位：Johns Hopkins University
摘要：Quantum mechanics depicts a counter-intuitive reality in which the act of observation influences what is observed - and few can agree on what that means.
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作者：Chiang, Chen-Yu; Ohashi, Masao; Le, Jessie; Chen, Pan-Pan; Zhou, Qingyang; Qu, Songrong; Bat-Erdene, Undramaa; Hematian, Shabnam; Rodriguez, Jose A.; Houk, K. N.; Guo, Yisong; Loo, Joseph A.; Tang, Yi
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of North Carolina; University of North Carolina Greensboro; Carnegie Mellon University; University of California System; University of California Los Angeles
摘要：Carbon-hydrogen (C-H) bonds are the foundation of essentially every organic molecule, making them an ideal place to do chemical synthesis. The key challenge is achieving selectivity for one particular C(sp(3))-H bond(1, 2-3). In recent years, metalloenzymes have been found to perform C(sp(3))-H bond functionalization(4,5). Despite substantial progresses in the past two decades(6,7), enzymatic halogenation and pseudohalogenation of unactivated C(sp(3))-H-providing a functional handle for furthe...
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作者：Tordeux, Antoine
作者单位：University of Wuppertal
摘要：Overcrowding can lead to disaster, and yet the dynamics of dense groups of people are poorly understood. Analysis of a festival uncovers collective rotational movements that emerge at critical densities, which could be universal.
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作者：Xu, Congling; Li, Chengyu; Chen, Jiwei; Xiong, Yan; Qiao, Zhibin; Fan, Pengyu; Li, Conghui; Ma, Shuangyu; Liu, Jin; Song, Aixia; Tao, Bolin; Xu, Tao; Xu, Wei; Chi, Yayun; Xue, Jingyan; Wang, Pu; Ye, Dan; Gu, Hongzhou; Zhang, Peng; Wang, Qiong; Xiao, Ruijing; Cheng, Jingdong; Zheng, Hai; Yu, Xiaoli; Zhang, Zhen; Wu, Jiong; Liang, Kaiwei; Liu, Yan-Jun; Lu, Huasong; Chen, Fei Xavier
