8049期

最新文章

• Microbes in space: how bacteria could help sustain long-distance space travel AI翻译
  作者：Dance, Amber
• Report both positive and negative effects of gene changes on crops AI翻译
  作者：Meng, Shujun; Zhang, Guan; Wu, Qingyu
  作者单位：Chinese Academy of Agricultural Sciences
• Stem-cell patches strengthened a woman's failing heart AI翻译
  作者：Naddaf, Miryam
• What lies beneath Europa's icy surface? Perhaps a heart of metal AI翻译
  作者：[Anonymous]
• Researching endangered animals in the Sahara has its own dangers AI翻译
  作者：Gil-Sanchez, Jose Maria; Ro, Christine
  作者单位：University of Granada
• How scientists labour on love and loss AI翻译
  作者：Sohn, Emily; Joel, Samantha
  作者单位：Western University (University of Western Ontario)
  摘要：Romance and relationships are research topics for some scientists in academia and the private sector. Nature asked them for their insights.
• Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences AI翻译
  作者：Brestoff, Jonathan R.
  作者单位：Washington University (WUSTL)
• The maternal X chromosome affects cognition and brain ageing in female mice AI翻译
  作者：Abdulai-Saiku, Samira; Gupta, Shweta; Wang, Dan; Marino, Francesca; Moreno, Arturo J.; Huang, Yu; Srivastava, Deepak; Panning, Barbara; Dubal, Dena B.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; The J David Gladstone Institutes; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Female mammalian cells have two X chromosomes, one of maternal origin and one of paternal origin. During development, one X chromosome randomly becomes inactivated1, 2, 3-4. This renders either the maternal X (Xm) chromosome or the paternal X (Xp) chromosome inactive, causing X mosaicism that varies between female individuals, with some showing considerable or complete skew of the X chromosome that remains active5, 6-7. Parent-of-X origin can modify epigenetics through DNA methylation8,9 and p...
• Immune evasion through mitochondrial transfer in the tumour microenvironment AI翻译
  作者：Ikeda, Hideki; Kawase, Katsushige; Nishi, Tatsuya; Watanabe, Tomofumi; Takenaga, Keizo; Inozume, Takashi; Ishino, Takamasa; Aki, Sho; Lin, Jason; Kawashima, Shusuke; Nagasaki, Joji; Ueda, Youki; Suzuki, Shinichiro; Makinoshima, Hideki; Itami, Makiko; Nakamura, Yuki; Tatsumi, Yasutoshi; Suenaga, Yusuke; Morinaga, Takao; Honobe-Tabuchi, Akiko; Ohnuma, Takehiro; Kawamura, Tatsuyoshi; Umeda, Yoshiyasu; Nakamura, Yasuhiro; Kiniwa, Yukiko; Ichihara, Eiki; Hayashi, Hidetoshi; Ikeda, Jun-ichiro; Hanazawa, Toyoyuki; Toyooka, Shinichi; Mano, Hiroyuki; Suzuki, Takuji; Osawa, Tsuyoshi; Kawazu, Masahito; Togashi, Yosuke
  作者单位：Chiba Cancer Center; Chiba University; Chiba University; Okayama University; Okayama University; Okayama University; Chiba Cancer Center; Chiba University; University of Yamanashi; Chiba University; University of Tokyo; University of Tokyo; Kindai University (Kinki University); National Cancer Center - Japan; Chiba Cancer Center; Chiba Cancer Center; Chiba Cancer Center; Kumamoto University; Saitama Medical University; Shinshu University; Chiba University; Okayama University; National Cancer Center - Japan; Chiba University; University of Tokyo; Kindai University (Kinki University)
  摘要：Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T cell attack1. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in tumour-infiltrating lymphocytes (TILs) impair antitumour immune responses2, 3-4. However, detailed mechanisms of such processes remain unclear. Here we analyse clinical specimens and identify mitochondrial DNA (mtDNA) mutations in TILs that are shared with cancer cells. Mo...
• Rapid and scalable personalized ASO screening in patient-derived organoids AI翻译
  作者：Means, John C.; Martinez-Bengochea, Anabel L.; Louiselle, Daniel A.; Nemechek, Jacqelyn M.; Perry, John M.; Farrow, Emily G.; Pastinen, Tomi; Younger, Scott T.
  作者单位：Children's Mercy Hospital; Children's Mercy Hospital; University of Missouri System; University of Missouri Kansas City; University of Kansas; University of Kansas Medical Center
  摘要：Personalized antisense oligonucleotides (ASOs) have achieved positive results in the treatment of rare genetic disease1. As clinical sequencing technologies continue to advance, the ability to identify patients with rare disease harbouring pathogenic genetic variants amenable to this therapeutic strategy will probably improve. Here we describe a scalable platform for generating patient-derived cellular models and demonstrate that these personalized models can be used for preclinical evaluation...