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作者：Dreiling, Reagan J.; Huynh, Kathleen; Fors, Brett P.
作者单位：Cornell University
摘要：Crosslinked thermosets are highly durable materials, but overcoming their petrochemical origins and inability to be recycled poses a grand challenge(1, 2-3). Many strategies to access crosslinked polymers that are bioderived or degradable-by-design have been proposed, but they require several resource-intensive synthesis and purification steps and are not yet feasible alternatives to conventional consumer materials(4, 5, 6, 7-8). Here we present a modular, one-pot synthesis of degradable therm...
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作者：Doglioni, Ginevra; Fernandez-Garcia, Juan; Igelmann, Sebastian; Altea-Manzano, Patricia; Blomme, Arnaud; La Rovere, Rita; Liu, Xiao-Zheng; Liu, Yawen; Tricot, Tine; Nobis, Max; An, Ning; Leclercq, Marine; El Kharraz, Sarah; Karras, Panagiotis; Hsieh, Yu-Heng; Solari, Fiorella A.; Martins Nascentes Melo, Luiza; Allies, Gabrielle; Scopelliti, Annalisa; Rossi, Matteo; Vermeire, Ines; Broekaert, Dorien; Ferreira Campos, Ana Margarida; Neven, Patrick; Maetens, Marion; Van Baelen, Karen; Alkan, H. Furkan; Planque, Melanie; Floris, Giuseppe; Sickmann, Albert; Tasdogan, Alpaslan; Marine, Jean-Christophe; Scheele, Colinda L. G. J.; Desmedt, Christine; Bultynck, Geert; Close, Pierre; Fendt, Sarah-Maria
作者单位：Flanders Institute for Biotechnology (VIB); KU Leuven; University of Liege; KU Leuven; Jiangsu University; Flanders Institute for Biotechnology (VIB); KU Leuven; Flanders Institute for Biotechnology (VIB); Flanders Institute for Biotechnology (VIB); KU Leuven; Dortmund University of Technology; Leibniz Association; Leibniz Institut fur Analytische Wissenschaften (ISAS); University of Duisburg Essen; Helmholtz Association; German Cancer Research Center (DKFZ); KU Leuven; University Hospital Leuven; KU Leuven; Flanders Institute for Biotechnology (VIB); KU Leuven; University Hospital Leuven; KU Leuven; Ruhr University Bochum; Universidad Pablo de Olavide; University of Sevilla; Consejo Superior de Investigaciones Cientificas (CSIC); University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：Lung metastases occur in up to 54% of patients with metastatic tumours(1,2). Contributing factors to this high frequency include the physical properties of the pulmonary system and a less oxidative environment that may favour the survival of cancer cells(3). Moreover, secreted factors from primary tumours alter immune cells and the extracellular matrix of the lung, creating a permissive pre-metastatic environment primed for the arriving cancer cells(4,5). Nutrients are also primed during pre-m...
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作者：Zhang, Ce; Liang, Dan; Ercan-Sencicek, A. Gulhan; Bulut, Aybike S.; Cortes, Joelly; Cheng, Iris Q.; Henegariu, Octavian; Nishimura, Sayoko; Wang, Xinyuan; Peksen, A. Buket; Takeo, Yutaka; Caglar, Caner; Lam, TuKiet T.; Koroglu, Merve Nur; Narayanan, Anand; Lopez-Giraldez, Francesc; Miyagishima, Danielle F.; Mishra-Gorur, Ketu; Barak, Tanyeri; Yasuno, Katsuhito; Erson-Omay, E. Zeynep; Yalcinkaya, Cengiz; Wang, Guilin; Mane, Shrikant; Kaymakcalan, Hande; Guzel, Aslan; Caglayan, A. Okay; Tuysuz, Beyhan; Sestan, Nenad; Gunel, Murat; Louvi, Angeliki; Bilguvar, Kaya
作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Acibadem University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Yale University; Yale University; Acibadem University; Yale University; Yale University; Yale University; Istanbul University - Cerrahpasa; Yale University; Acibadem University; Bahcesehir University; Dokuz Eylul University; Dokuz Eylul University; Istanbul University - Cerrahpasa; Yale University; Yale University; Yale University; Yale University; Yale University; Yale New Haven Hospital; Acibadem University; Acibadem University; Bezmialem Vakif University
摘要：Cerebral cortex development in humans is a highly complex and orchestrated process that is under tight genetic regulation. Rare mutations that alter gene expression or function can disrupt the structure of the cerebral cortex, resulting in a range of neurological conditions(1). Lissencephaly ('smooth brain') spectrum disorders comprise a group of rare, genetically heterogeneous congenital brain malformations commonly associated with epilepsy and intellectual disability(2). However, the molecul...
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作者：Karnatak, Paritosh; Schoenenberger, Christian
作者单位：University of Basel
摘要：A superconducting state can be induced in a twisted carbon-based material, but it can't be described with conventional theory. A technique using high-frequency circuits could reveal the mechanism behind this fascinating state.
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作者：Sayer, Catherine A.; Fernando, Eresha; Jimenez, Randall R.; Macfarlane, Nicholas B. W.; Rapacciuolo, Giovanni; Boehm, Monika; Brooks, Thomas M.; Contreras-MacBeath, Topiltzin; Cox, Neil A.; Harrison, Ian; Hoffmann, Michael; Jenkins, Richard; Smith, Kevin G.; Vie, Jean-Christophe; Abbott, John C.; Allen, David J.; Allen, Gerald R.; Barrios, Violeta; Boudot, Jean-Pierre; Carrizo, Savrina F.; Charvet, Patricia; Clausnitzer, Viola; Congiu, Leonardo; Crandall, Keith A.; Cumberlidge, Neil; Cuttelod, Annabelle; Dalton, James; Daniels, Adam G.; De Grave, Sammy; De Knijf, Geert; Dijkstra, Klaas-Douwe B.; Dow, Rory A.; Freyhof, Joerg; Garcia, Nieves; Gessner, Joern; Getahun, Abebe; Gibson, Claudine; Gollock, Matthew J.; Grant, Michael I.; Groom, Alice E. R.; Hammer, Michael P.; Hammerson, Geoffrey A.; Hilton-Taylor, Craig; Hodgkinson, Laurel; Holland, Robert A.; Jabado, Rima W.; Juffe Bignoli, Diego; Kalkman, Vincent J.; Karimov, Bakhtiyor K.; Kipping, Jens; Kottelat, Maurice; Laleye, Philippe A.; Larson, Helen K.; Lintermans, Mark; Lozano, Federico; Ludwig, Arne; Lyons, Timothy J.; Maiz-Tome, Laura; Molur, Sanjay; Ng, Heok Hee; Numa, Catherine; Palmer-Newton, Amy F.; Pike, Charlotte; Pippard, Helen E.; Polaz, Carla N. M.; Pollock, Caroline M.; Raghavan, Rajeev; Rand, Peter S.; Ravelomanana, Tsilavina; Reis, Roberto E.; Rigby, Cassandra L.; Scott, Janet A.; Skelton, Paul H.; Sloat, Matthew R.; Snoeks, Jos; Stiassny, Melanie L. J.; Tan, Heok Hui; Taniguchi, Yoshinori; Thorstad, Eva B.; Tognelli, Marcelo F.; Torres, Armi G.; Torres, Yan; Tweddle, Denis; Watanabe, Katsutoshi; Westrip, James R. S.; Wright, Emma G. E.; Zhang, E.; Darwall, William R. T.
作者单位：Universidad Autonoma del Estado de Morelos; Conservation International; Northern Arizona University; Zoological Society of London; University of Alabama System; University of Alabama Tuscaloosa; Western Australian Museum; Centre National de la Recherche Scientifique (CNRS); Universite de Lorraine; Universidade Federal do Ceara; University of Padua; George Washington University; Northern Michigan University; University of Oxford; Research Institute for Nature & Forest; Naturalis Biodiversity Center; University of Malaysia Sarawak; Leibniz Institut fur Evolutions und Biodiversitatsforschung; Leibniz Association; Leibniz Institut fur Gewasserokologie und Binnenfischerei (IGB); Addis Ababa University; James Cook University; James Cook University; Universitas Hasanuddin; Royal Society for Protection of Birds; University of Southampton; University of Kent; Tashkent Institute of Irrigation & Agricultural Mechanization Engineers; University of Abomey Calavi; University of Canberra; Leibniz Institut fur Zoo und Wildtierforschung; Humboldt University of Berlin; National University of Singapore; Kerala University of Fisheries & Ocean Studies; University Antananarivo; Pontificia Universidade Catolica Do Rio Grande Do Sul; National Research Foundation - South Africa; South African Institute for Aquatic Biodiversity; Royal Museum for Central Africa; KU Leuven; American Museum of Natural History (AMNH); Meijo University; Norwegian Institute Nature Research; Mindanao State University System; Mindanao State University-IIT; Kyoto University; Chinese Academy of Sciences; Institute of Hydrobiology, CAS
摘要：Freshwater ecosystems are highly biodiverse(1) and important for livelihoods and economic development(2), but are under substantial stress(3). To date, comprehensive global assessments of extinction risk have not included any speciose groups primarily living in freshwaters. Consequently, data from predominantly terrestrial tetrapods(4,5) are used to guide environmental policy(6) and conservation prioritization(7), whereas recent proposals for target setting in freshwaters use abiotic factors(8...
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作者：Wolff, Eric W.; Mulvaney, Robert; Grieman, Mackenzie M.; Hoffmann, Helene M.; Humby, Jack; Nehrbass-Ahles, Christoph; Rhodes, Rachael H.; Rowell, Isobel F.; Sime, Louise C.; Fischer, Hubertus; Stocker, Thomas F.; Landais, Amaelle; Parrenin, Frederic; Steig, Eric J.; Duetsch, Marina; Golledge, Nicholas R.
作者单位：University of Cambridge; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; Eberhard Karls University of Tubingen; National Physical Laboratory - UK; University of Bern; University of Bern; CEA; Universite Paris Saclay; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); INRAE; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut National Polytechnique de Grenoble; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Vienna; Victoria University Wellington
摘要：The fate of the West Antarctic Ice Sheet (WAIS)(1) is the largest cause of uncertainty in long-term sea-level projections. In the last interglacial (LIG) around 125,000 years ago, data suggest that sea level was several metres higher than today(2, 3-4), and required a significant contribution from Antarctic ice loss, with WAIS usually implicated. Antarctica and the Southern Ocean were warmer than today(5, 6, 7-8), by amounts comparable to those expected by 2100 under moderate to high future wa...
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作者：Zhang, Ce; Liang, Dan; Ercan-Sencicek, A. Gulhan; Bulut, Aybike S.; Cortes, Joelly; Cheng, Iris Q.; Henegariu, Octavian; Nishimura, Sayoko; Wang, Xinyuan; Peksen, A. Buket; Takeo, Yutaka; Caglar, Caner; Lam, TuKiet T.; Koroglu, Merve Nur; Narayanan, Anand; Lopez-Giraldez, Francesc; Miyagishima, Danielle F.; Mishra-Gorur, Ketu; Barak, Tanyeri; Yasuno, Katsuhito; Erson-Omay, E. Zeynep; Yalcinkaya, Cengiz; Wang, Guilin; Mane, Shrikant; Kaymakcalan, Hande; Guzel, Aslan; Caglayan, A. Okay; Tuysuz, Beyhan; Sestan, Nenad; Gunel, Murat; Louvi, Angeliki; Bilguvar, Kaya
作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Acibadem University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Yale University; Yale University; Acibadem University; Yale University; Yale University; Yale University; Istanbul University - Cerrahpasa; Yale University; Acibadem University; Bahcesehir University; Dokuz Eylul University; Dokuz Eylul University; Istanbul University - Cerrahpasa; Yale University; Yale University; Yale University; Yale University; Yale University; Yale New Haven Hospital; Acibadem University; Acibadem University; Bezmialem Vakif University
摘要：Cerebral cortex development in humans is a highly complex and orchestrated process that is under tight genetic regulation. Rare mutations that alter gene expression or function can disrupt the structure of the cerebral cortex, resulting in a range of neurological conditions(1). Lissencephaly ('smooth brain') spectrum disorders comprise a group of rare, genetically heterogeneous congenital brain malformations commonly associated with epilepsy and intellectual disability(2). However, the molecul...
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作者：Heberlig, Graham W.; La Clair, James J.; Burkart, Michael D.
作者单位：University of California System; University of California San Diego
摘要：Non-ribosomal peptide synthetases are assembly line biosynthetic pathways that are used to produce critical therapeutic drugs and are typically arranged as large multi-domain proteins called megasynthetases(1). They synthesize polypeptides using peptidyl carrier proteins that shuttle each amino acid through modular loading, modification and elongation(2) steps, and remain challenging to structurally characterize, owing in part to the inherent dynamics of their multi-domain and multi-modular ar...
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作者：O'Dwyer, Michael R.; Azagury, Meir; Furlong, Katharine; Alsheikh, Amani; Hall-Ponsele, Elisa; Pinto, Hugo; Fyodorov, Dmitry V.; Jaber, Mohammad; Papachristoforou, Eleni; Benchetrit, Hana; Ashmore, James; Makedonski, Kirill; Rahamim, Moran; Hanzevacki, Marta; Yassen, Hazar; Skoda, Samuel; Levy, Adi; Pollard, Steven M.; Skoultchi, Arthur I.; Buganim, Yosef; Soufi, Abdenour
作者单位：University of Edinburgh; University of Edinburgh; Hebrew University of Jerusalem; University of Edinburgh; King Abdulaziz City for Science & Technology; Yeshiva University
摘要：Cellular identity requires the concerted action of multiple transcription factors (TFs) bound together to enhancers of cell-type-specific genes. Despite TFs recognizing specific DNA motifs within accessible chromatin, this information is insufficient to explain how TFs select enhancers(1). Here we compared four different TF combinations that induce different cell states, analysing TF genome occupancy, chromatin accessibility, nucleosome positioning and 3D genome organization at the nucleosome ...
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作者：Sun, Eric D.; Zhou, Olivia Y.; Hauptschein, Max; Rappoport, Nimrod; Xu, Lucy; Navarro Negredo, Paloma; Liu, Ling; Rando, Thomas A.; Zou, James; Brunet, Anne
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Stanford University; Stanford University; Stanford University
摘要：Old age is associated with a decline in cognitive function and an increase in neurodegenerative disease risk(1). Brain ageing is complex and is accompanied by many cellular changes(2). Furthermore, the influence that aged cells have on neighbouring cells and how this contributes to tissue decline is unknown. More generally, the tools to systematically address this question in ageing tissues have not yet been developed. Here we generate a spatially resolved single-cell transcriptomics brain atl...
