作者：Rangari, Vipin Ashok; O'Brien, Evan S.; Powers, Alexander S.; Slivicki, Richard A.; Bertels, Zachariah; Appourchaux, Kevin; Aydin, Deniz; Ramos-Gonzalez, Nokomis; Mwirigi, Juliet; Lin, Li; Mangutov, Elizaveta; Sobecks, Briana L.; Awad-Agbaria, Yaseen; Uphade, Manoj B.; Aguilar, Jhoan; Peddada, Teja Nikhil; Shiimura, Yuki; Huang, Xi-Ping; Folarin-Hines, Jakayla; Payne, Maria; Kalathil, Anirudh; Varga, Balazs R.; Kobilka, Brian K.; Pradhan, Amynah A.; Cameron, Michael D.; Kumar, Kaavya Krishna; Dror, Ron O.; Gereau, Robert W.; Majumdar, Susruta
作者单位：University of Health Sciences & Pharmacy in St. Louis; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Stanford University; Stanford University; Stanford University; Stanford University; State University System of Florida; University of Florida; Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology; Kurume University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Johns Hopkins University
摘要：The current opioid overdose epidemic highlights the urgent need to develop safer and more effective treatments for chronic pain1. Cannabinoid receptor type 1 (CB1) is a promising non-opioid target for pain relief, but its clinical use has been limited by centrally mediated psychoactivity and tolerance. We overcame both issues by designing peripherally restricted CB1 agonists that minimize arrestin recruitment. We achieved these goals by computationally designing positively charged derivatives ...
作者：Kong, Lingyuan; Papaj, Michal; Kim, Hyunjin; Zhang, Yiran; Baum, Eli; Li, Hui; Watanabe, Kenji; Taniguchi, Takashi; Gu, Genda; Lee, Patrick A.; Nadj-Perge, Stevan
作者单位：California Institute of Technology; California Institute of Technology; University of Houston System; University of Houston; University of California System; University of California Berkeley; California Institute of Technology; Northwestern University; National Institute for Materials Science; United States Department of Energy (DOE); Brookhaven National Laboratory; Massachusetts Institute of Technology (MIT)
摘要：Superconducting (SC) states that break space-group symmetries of the underlying crystal can exhibit nontrivial spatial modulation of the order parameter. Previously, such states were intimately associated with the breaking of translational symmetry1,2, resulting in the density-wave orders3, 4, 5, 6, 7-8, with wavelengths spanning several unit cells9, 10, 11, 12, 13, 14, 15, 16, 17, 18-19. However, a related basic concept has long been overlooked20: when only intra-unit-cell symmetries of the s...
