8057期

最新文章

• Fine-scale patterns of SARS-CoV-2 spread from identical pathogen sequences AI翻译
  作者：Tran-Kiem, Cecile; Paredes, Miguel I.; Perofsky, Amanda C.; Frisbie, Lauren A.; Xie, Hong; Kong, Kevin; Weixler, Amelia; Greninger, Alexander L.; Roychoudhury, Pavitra; Peterson, JohnAric M.; Delgado, Andrew; Halstead, Holly; Mackellar, Drew; Dykema, Philip; Gamboa, Luis; Frazar, Chris D.; Ryke, Erica; Stone, Jeremy; Reinhart, David; Starita, Lea; Thibodeau, Allison; Yun, Cory; Aragona, Frank; Black, Allison; Viboud, Cecile; Bedford, Trevor
  作者单位：Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC); University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute
  摘要：Pathogen genomics can provide insights into underlying infectious disease transmission patterns1,2, but new methods are needed to handle modern large-scale pathogen genome datasets and realize this full potential3, 4-5. In particular, genetically proximal viruses should be highly informative about transmission events as genetic proximity indicates epidemiological linkage. Here we use pairs of identical sequences to characterize fine-scale transmission patterns using 114,298 SARS-CoV-2 genomes ...
• Meet 'qudits': more complex cousins of qubits boost quantum computing AI翻译
  作者：Castelvecchi, Davide
• Mathematician who reshaped theory of symmetry wins Abel Prize AI翻译
  作者：Castelvecchi, Davide
• The full lethal impact of massive cuts to international food aid AI翻译
  作者：Osendarp, Saskia; Ruel, Marie; Udomkesmalee, Emorn; Tessema, Masresha; Haddad, Lawrence
  作者单位：CGIAR; International Food Policy Research Institute (IFPRI); Mahidol University
• 'Open source' AI isn't truly open - here's how researchers can reclaim the term AI翻译
  作者：Maffulli, Stefano
• Millimetre-scale bioresorbable optoelectronic systems for electrotherapy AI翻译
  作者：Zhang, Yamin; Rytkin, Eric; Zeng, Liangsong; Kim, Jong Uk; Tang, Lichao; Zhang, Haohui; Mikhailov, Aleksei; Zhao, Kaiyu; Wang, Yue; Ding, Li; Lu, Xinyue; Lantsova, Anastasia; Aprea, Elena; Jiang, Gengming; Li, Shupeng; Seo, Seung Gi; Wang, Tong; Wang, Jin; Liu, Jiayang; Gu, Jianyu; Liu, Fei; Bailey, Keith; Li, Yat Fung Larry; Burrell, Amy; Pfenniger, Anna; Ardashev, Andrey; Yang, Tianyu; Liu, Naijia; Lv, Zengyao; Purwanto, Nathan S.; Ying, Yue; Lu, Yinsheng; Hoepfner, Claire; Melisova, Altynai; Gong, Jiarui; Jeong, Jinheon; Choi, Junhwan; Hou, Alex; Nolander, Rachel; Bai, Wubin; Jin, Sung Hun; Ma, Zhenqiang; Torkelson, John M.; Huang, Yonggang; Ouyang, Wei; Arora, Rishi K.; Efimov, Igor R.; Rogers, John A.
  作者单位：Northwestern University; Northwestern University; National University of Singapore; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine; Northwestern University; Huazhong University of Science & Technology; Scuola Superiore Sant'Anna; Northwestern University; Alnylam Pharmaceuticals; Northwestern University; Feinberg School of Medicine; Northwestern University; University of Wisconsin System; University of Wisconsin Madison; Incheon National University; Dankook University; University of North Carolina; University of North Carolina Chapel Hill; Dartmouth College; University of Chicago
  摘要：Temporary pacemakers are essential for the care of patients with short-lived bradycardia in post-operative and other settings1, 2, 3-4. Conventional devices require invasive open-heart surgery or less invasive endovascular surgery, both of which are challenging for paediatric and adult patients5, 6, 7-8. Other complications9, 10-11 include risks of infections, lacerations and perforations of the myocardium, and of displacements of external power supplies and control systems. Here we introduce ...
• Systems-level design principles of metabolic rewiring in an animal AI翻译
  作者：Li, Xuhang; Zhang, Hefei; Hodder, Thomas; Wang, Wen; Myers, Chad L.; Yilmaz, L. Safak; Walhout, Albertha J. M.
  作者单位：University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：The regulation of metabolism is vital to any organism and can be achieved by transcriptionally activating or repressing metabolic genes1, 2-3. Although many examples of transcriptional metabolic rewiring have been reported4, a systems-level study of how metabolism is rewired in response to metabolic perturbations is lacking in any animal. Here we apply Worm Perturb-Seq (WPS)-a high-throughput method combining whole-animal RNA-interference and RNA-sequencing5-to around 900 metabolic genes in th...
• New antibiotic that kills drug-resistant bacteria discovered in technician's garden AI翻译
  作者：Mallapaty, Smriti
• Photoinduced copper-catalysed deracemization of alkyl halides AI翻译
  作者：Zhong, Feng; Li, Renhe; Mai, Binh Khanh; Liu, Peng; Fu, Gregory C.
  作者单位：California Institute of Technology; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Deracemization is an emerging strategy for generating enantioenriched compounds wherein the two enantiomers of a readily available racemic starting material are transformed into a single enantiomer, typically through the action of a light-induced catalyst(1,2). Excellent proof of principle for this potentially powerful approach to asymmetric catalysis has been described(3, 4, 5, 6, 7-8); nevertheless, substantial challenges have not yet been addressed, including the exploitation of carbon-hete...
• Endogenous DNA damage at sites of terminated transcripts AI翻译
  作者：Liu, Jingjing; Perren, Jullian O.; Rogers, Cody M.; Nimer, Sadeieh; Wen, Alice X.; Halliday, Jennifer A.; Fitzgerald, Devon M.; Mei, Qian; Nehring, Ralf B.; Crum, Mary; Kozmin, Stanislav G.; Xia, Jun; Cooke, Matthew B.; Zhai, Yin; Bates, David; Li, Lei; Hastings, P. J.; Artsimovitch, Irina; Herman, Christophe; Sung, Patrick M.; Miller, Kyle M.; Rosenberg, Susan M.
  作者单位：Baylor College of Medicine; Baylor College of Medicine; University of Texas System; University of Texas Austin; University of Texas System; University of Texas at San Antonio; Baylor College of Medicine; Baylor College of Medicine; University of Texas System; UTMD Anderson Cancer Center; University System of Ohio; Ohio State University; Emory University
  摘要：DNA damage promotes mutations that fuel cancer, ageing and neurodegenerative diseases1, 2-3, but surprisingly, the causes and types of damage remain largely unknown. There are three identified mechanisms that damage DNA during transcription: collision of RNA polymerase (RNAP) with the DNA-replication machinery head-on and co-directionally4, 5-6, and R-loop-induced DNA breakage7, 8, 9-10. Here we identify novel DNA damage reaction intermediates11,12 and uncover a fourth transcription-related so...