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作者:Xie, Jijia; Fu, Cong; Quesne, Matthew G.; Guo, Jian; Wang, Chao; Xiong, Lunqiao; Windle, Christopher D.; Gadipelli, Srinivas; Guo, Zheng Xiao; Huang, Weixin; Catlow, C. Richard A.; Tang, Junwang
作者单位:University of London; University College London; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Cardiff University; University of Leeds; University of London; University College London; Tsinghua University; University of Hong Kong
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作者:Reilly, Emma L.; Aitken, Sarah J.
作者单位:Cancer Research UK; University of Cambridge; CRUK Cambridge Institute; Yale University; Yale New Haven Hospital; Yale University
摘要:An ingenious technique reveals how stressed cells divide to produce progeny that have different traits - a phenomenon that can initiate cancer.
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作者:Fialko, Yuri; Kaneko, Yoshihiro
作者单位:University of California System; University of California San Diego; Scripps Institution of Oceanography; Kyoto University
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作者:Sousa, Margarida; Bujalski, Pawel; Cruz, Bruno F.; Louie, Kenway; McNamee, Daniel C.; Paton, Joseph J.
作者单位:Fundacao Champalimaud; New York University
摘要:Midbrain dopamine neurons (DANs) signal reward-prediction errors that teach recipient circuits about expected rewards1. However, DANs are thought to provide a substrate for temporal difference (TD) reinforcement learning (RL), an algorithm that learns the mean of temporally discounted expected future rewards, discarding useful information about experienced distributions of reward amounts and delays2. Here we present time-magnitude RL (TMRL), a multidimensional variant of distributional RL that...
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作者:Wu, S. Y. Celeste; Whited, Jessica L.
作者单位:Harvard University
摘要:The molecular feedback loops that program positional identity as salamander limbs develop and regrow could be harnessed for regenerative medicine.
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作者:Dreyer, Jacob
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作者:Kwon, Diana
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作者:Tsarev, Sergey; Proniakova, Daria; Liu, Xuqi; Wu, Erfu; Matt, Gebhard J.; Sakhatskyi, Kostiantyn; Ferraresi, Lorenzo L. A.; Kothandaraman, Radha; Fu, Fan; Shorubalko, Ivan; Yakunin, Sergii; Kovalenko, Maksym V.
作者单位:Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Laboratories for Materials Science & Technology (EMPA); Swiss Federal Institutes of Technology Domain; Swiss Federal Laboratories for Materials Science & Technology (EMPA)
摘要:Modern colour image sensors face challenges in further improving sensitivity and image quality because of inherent limitations in light utilization efficiency1. A major factor contributing to these limitations is the use of passive optical filters, which absorb and dissipate a substantial amount of light, thereby reducing the efficiency of light capture2. On the contrary, active optical filtering in Foveon-type vertically stacked architectures still struggles to deliver optimal performance owi...
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作者:[Anonymous]
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作者:Kennedy, M. S.; Freiburger, A.; Cooper, M.; Beilsmith, K.; George, M. L. St; Kalski, M.; Cham, C.; Guzzetta, A.; Ng, S. C.; Chan, F. K.; DeLeon, O.; Rubin, D.; Henry, C. S.; Bergelson, J.; Chang, E. B.
作者单位:University of Chicago; University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; University of Chicago; University of Chicago; Chinese University of Hong Kong; Chinese University of Hong Kong; University of Chicago; New York University; Northwestern University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Loyola University Chicago
摘要:A high-fat, low-fibre Western-style diet (WD) induces microbiome dysbiosis characterized by reduced taxonomic diversity and metabolic breadth(1,2), which in turn increases risk for a wide array of metabolic(3, 4-5), immune(6) and systemic pathologies. Recent work has established that WD can impair microbiome resilience to acute perturbations such as antibiotic treatment(7,8), although little is known about the mechanism of impairment and the specific consequences for the host of prolonged post...