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作者:Nordling, Linda
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作者:Masset, Paul; Tano, Pablo; Kim, HyungGoo R.; Malik, Athar N.; Pouget, Alexandre; Uchida, Naoshige
作者单位:Harvard University; Harvard University; McGill University; Mila Quebec Artificial Intelligence Institute; University of Geneva; Sungkyunkwan University (SKKU); Institute for Basic Science - Korea (IBS); Brown University; Lifespan Health Rhode Island; Rhode Island Hospital; Harvard University
摘要:To thrive in complex environments, animals and artificial agents must learn to act adaptively to maximize fitness and rewards. Such adaptive behaviour can be learned through reinforcement learning1, a class of algorithms that has been successful at training artificial agents2, 3, 4-5 and at characterizing the firing of dopaminergic neurons in the midbrain6, 7-8. In classical reinforcement learning, agents discount future rewards exponentially according to a single timescale, known as the disco...
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作者:Fieldhouse, Rachel; Mallapaty, Smriti
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作者:Du, Jianghui; Haley, Brian A.; McManus, James; Blaser, Patrick; Rickli, Jorg; Vance, Derek
作者单位:Swiss Federal Institutes of Technology Domain; ETH Zurich; Peking University; Oregon State University; Bigelow Laboratory for Ocean Sciences; University of Lausanne; Helmholtz Association; GEOMAR Helmholtz Center for Ocean Research Kiel
摘要:Trace elements and isotopes (TEIs) are important to marine life and are essential tools for studying ocean processes1. Two different frameworks have arisen regarding marine TEI cycling: reversible scavenging favours water-column control on TEI distributions2, 3, 4-5, and seafloor boundary exchange emphasizes sedimentary imprints on water-column biogeochemistry6,7. These two views lead to disparate interpretations of TEI behaviours8, 9-10. Here we use rare earth elements and neodymium isotopes ...
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作者:[Anonymous]
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作者:[Anonymous]
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作者:Fernando, Michael B.; Fan, Yu; Zhang, Yanchun; Tokolyi, Alex; Murphy, Aleta N.; Kammourh, Sarah; Deans, P. J. Michael; Ghorbani, Sadaf; Onatzevitch, Ryan; Pero, Adriana; Padilla, Christopher; Williams, Sarah E.; Flaherty, Erin K.; Prytkova, Iya A.; Cao, Lei; Knowles, David A.; Fang, Gang; Slesinger, Paul A.; Brennand, Kristen J.
作者单位:Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Yale University; Icahn School of Medicine at Mount Sinai; University of Bergen; Haukeland University Hospital; University of Bergen; Columbia University; Columbia University; Columbia University; Yale University; Yale University
摘要:Given the large number of genes significantly associated with risk for neuropsychiatric disorders, a critical unanswered question is the extent to which diverse mutations-sometimes affecting the same gene-will require tailored therapeutic strategies. Here we consider this in the context of rare neuropsychiatric disorder-associated copy number variants (2p16.3) resulting in heterozygous deletions in NRXN1, which encodes a presynaptic cell-adhesion protein that serves as a critical synaptic orga...
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作者:Castelvecchi, Davide
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作者:Davare, Monika A.
作者单位:Oregon Health & Science University
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作者:Gao, Ziyue
作者单位:University of Pennsylvania
摘要:Genomic analyses of mother-father-fetus trios after early pregnancy loss uncover contributions from chromosomal abnormalities and subtle genetic variants.