8072期

最新文章

• Memory gets a boost from positive emotion AI翻译
  作者：[Anonymous]
• Refractory solid condensation detected in an embedded protoplanetary disk AI翻译
  作者：McClure, M. K.; Van't Hoff, Merel; Francis, Logan; Bergin, Edwin; Rocha, Will R. M.; Sturm, J. A.; Harsono, Daniel; van Dishoeck, Ewine F.; Black, John H.; Noble, J. A.; Qasim, D.; Dartois, E.
  作者单位：Leiden University - Excl LUMC; Leiden University; University of Michigan System; University of Michigan; Purdue University System; Purdue University; Leiden University - Excl LUMC; Leiden University; National Tsing Hua University; Chalmers University of Technology; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Southwest Research Institute; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay
  摘要：Terrestrial planets and small bodies in our Solar System are theorized to have assembled from interstellar solids mixed with rocky solids that precipitated from a hot, cooling gas1,2. The first high-temperature minerals to recondense from this gaseous reservoir start the clock on planet formation3,4. However, the production mechanism of this initial hot gas and its importance to planet formation in other systems are unclear. Here we report the astronomical detection of this t = 0 moment, captu...
• Research-integrity sleuths say their work is being 'twisted' to undermine science AI翻译
  作者：Naddaf, Miryam
• Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin AI翻译
  作者：Raymond, Jeremy H.; Aktary, Zackie; Pouteaux, Marie; Petit, Valerie; Luciani, Flavie; Wehbe, Maria; Gizzi, Patrick; Bourban, Claire; Decaudin, Didier; Nemati, Fariba; Martianov, Igor; Davidson, Irwin; Tomasetto, Catherine-Laure; White, Richard M.; Mahuteau-Betzer, Florence; Vergier, Beatrice; Larue, Lionel; Delmas, Veronique
  作者单位：Universite PSL; UNICANCER; Institut Curie; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris Saclay; Universite PSL; UNICANCER; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; UNICANCER; Universite PSL; Institut Curie; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; University of Oxford; Ludwig Institute for Cancer Research; UNICANCER; Universite PSL; Institut Curie; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Bordeaux; CHU Bordeaux; Universite de Bordeaux; Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：Sex inequalities in cancer are well documented, but the current limited understanding is hindering advances in precision medicine and therapies1. Consideration of ethnicity, age and sex is essential for the management of cancer patients because they underlie important differences in both incidence and response to treatment2,3. Age-related hormone production, which is a consistent divergence between the sexes, is underestimated in cancers that are not recognized as being hormone dependent4, 5-6...
• Stepwise ATP translocation into the endoplasmic reticulum by human SLC35B1 AI翻译
  作者：Gulati, Ashutosh; Ahn, Do-Hwan; Suades, Albert; Hult, Yurie; Wolf, Gernot; Iwata, So; Superti-Furga, Giulio; Nomura, Norimichi; Drew, David
  作者单位：Stockholm University; Austrian Academy of Sciences; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences; Kyoto University; Medical University of Vienna
  摘要：ATP generated in the mitochondria is exported by an ADP/ATP carrier of the SLC25 family1. The endoplasmic reticulum (ER) cannot synthesize ATP but must import cytoplasmic ATP to energize protein folding, quality control and trafficking2,3. It was recently proposed that a member of the nucleotide sugar transporter family, termed SLC35B1 (also known as AXER), is not a nucleotide sugar transporter but a long-sought-after ER importer of ATP4. Here we report that human SLC35B1 does not bind nucleot...
• Optical nonlinearities in excess of 500 through sublattice reconstruction AI翻译
  作者：Chen, Jiaye; Liu, Chang; Xi, Shibo; Tan, Shengdong; He, Qian; Liang, Liangliang; Liu, Xiaogang
  作者单位：National University of Singapore; Xiamen University; Agency for Science Technology & Research (A*STAR); National University of Singapore; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Materials Research & Engineering (IMRE); National University of Singapore
  摘要：The ability of materials to respond to stimuli with significant optical nonlinearity is crucial for technological advancement and innovation1, 2-3. Although photon-avalanche upconversion nanomaterials with nonlinearities exceeding 60 have been developed, further enhancement remains challenging4, 5-6. Here we present a method to increase photon-avalanche nonlinearity beyond 500 by reconstructing the sublattice and extending the avalanche network. We demonstrate that lutetium substitution in the...
• Global terrestrial nitrogen fixation and its modification by agriculture AI翻译
  作者：Reis Ely, Carla R.; Perakis, Steven S.; Cleveland, Cory C.; Menge, Duncan N. L.; Reed, Sasha C.; Taylor, Benton N.; Batterman, Sarah A.; Clark, Christopher M.; Crews, Timothy E.; Dynarski, Katherine A.; Gei, Maga; Gundale, Michael J.; Herridge, David F.; Jovan, Sarah E.; Kou-Giesbrecht, Sian; Peoples, Mark B.; Piipponen, Johannes; Rodriguez-Caballero, Emilio; Salmon, Verity G.; Soper, Fiona M.; Staccone, Anika P.; Weber, Bettina; Williams, Christopher A.; Wurzburger, Nina
  作者单位：Oregon State University; United States Department of the Interior; United States Geological Survey; University of Montana System; University of Montana; Columbia University; United States Department of the Interior; United States Geological Survey; Harvard University; Cary Institute of Ecosystem Studies; University of Leeds; Smithsonian Institution; Smithsonian Tropical Research Institute; United States Environmental Protection Agency; Swedish University of Agricultural Sciences; University of New England; United States Department of Agriculture (USDA); United States Forest Service; Dalhousie University; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Agriculture & Food; Aalto University; Universidad de Almeria; Universidad de Almeria; Max Planck Society; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; McGill University; McGill University; University of Graz; Clark University; University System of Georgia; University of Georgia; Oak Ridge Associated Universities; United States Department of Energy (DOE); Oak Ridge Institute for Science & Education
  摘要：Biological nitrogen fixation (BNF) is the largest natural source of new nitrogen (N) that supports terrestrial productivity1,2, yet estimates of global terrestrial BNF remain highly uncertain3,4. Here we show that this uncertainty is partly because of sampling bias, as field BNF measurements in natural terrestrial ecosystems occur where N fixers are 17 times more prevalent than their mean abundances worldwide. To correct this bias, we develop new estimates of global terrestrial BNF by upscalin...
• In vivo screen of Plasmodium targets for mosquito-based malaria control AI翻译
  作者：Probst, Alexandra S.; Paton, Douglas G.; Appetecchia, Federico; Bopp, Selina; Adams, Kelsey L.; Rinvee, Tasneem A.; Pou, Sovitj; Winter, Rolf; Du, Esrah W.; Yahiya, Sabrina; Vidoudez, Charles; Singh, Naresh; Rodrigues, Janneth; Castaneda-Casado, Pablo; Tammaro, Chiara; Chen, Daisy; Godinez-Macias, Karla P.; Jaramillo, Jasmine L.; Poce, Giovanna; Rubal, Michael J.; Nilsen, Aaron; Winzeler, Elizabeth A.; Baum, Jake; Burrows, Jeremy N.; Riscoe, Michael K.; Wirth, Dyann F.; Catteruccia, Flaminia
  作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Imperial College London; GlaxoSmithKline; Glaxosmithkline United Kingdom; Sapienza University Rome; University of California System; University of California San Diego; Southwest Research Institute; Oregon Health & Science University; University of New South Wales Sydney; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Howard Hughes Medical Institute; University System of Georgia; University of Georgia
  摘要：The decline in malaria deaths has recently stalled owing to several factors, including the widespread resistance of Anopheles vectors to the insecticides used in long-lasting insecticide-treated nets (LLINs)1,2. One way to mitigate insecticide resistance is to directly kill parasites during their mosquito-stage of development by incorporating antiparasitic compounds into LLINs. This strategy can prevent onward parasite transmission even when insecticides lose efficacy3,4. Here, we performed an...
• Bring science into business schools to train the leaders of tomorrow AI翻译
  作者：Agarwala, Matthew
  作者单位：University of Sussex
• Range extender mediates long-distance enhancer activity AI翻译
  作者：Bower, Grace; Hollingsworth, Ethan W.; Jacinto, Sandra H.; Alcantara, Joshua A.; Clock, Benjamin; Cao, Kaitlyn; Liu, Mandy; Dziulko, Adam; Alcaina-Caro, Ana; Xu, Qianlan; Skowronska-Krawczyk, Dorota; Lopez-Rios, Javier; Dickel, Diane E.; Bardet, Anais F.; Pennacchio, Len A.; Visel, Axel; Kvon, Evgeny Z.
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology (CABD); University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; Universidad Loyola Andalucia; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; University of California System; University of California Merced
  摘要：Although most mammalian transcriptional enhancers regulate their cognate promoters over distances of tens of kilobases, some enhancers act over distances in the megabase range1. The sequence features that enable such long-distance enhancer-promoter interactions remain unclear. Here we used in vivo enhancer-replacement experiments at the mouse Shh locus to show that short- and medium-range limb enhancers cannot initiate gene expression at long-distance range. We identify a cis-acting element, r...