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作者：Chaves-Perez, Almudena; Millman, Scott E.; Janaki-Raman, Sudha; Ho, Yu-Jui; Hinterleitner, Clemens; Barthet, Valentin J. A.; Morris, John P.; Barriga, Francisco M.; Reyes, Jose; Kyaw, Aye; Pasolli, H. Amalia; Pe'er, Dana; Thompson, Craig B.; Finley, Lydia W. S.; Cross, Justin R.; Lowe, Scott W.
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作者：Zhao, Beibei; Xu, Yuanyuan; Zhu, Qin; Liu, Aokun; Peng, Xichao; Zhang, Tianying; Yu, Lu; Zhang, Yan; Huang, Xiaoqiang
作者单位：Nanjing University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Hefei Institutes of Physical Science, CAS
摘要：Electrochemistry is undergoing a resurgence in synthetic chemistry and has compelling advantages1. Repurposing natural enzymes through synthetic chemical strategies holds promise for exploring new chemical space2, 3, 4, 5-6. Elegant strategies, including directed evolution7, 8, 9-10, artificial enzymes11 and photoenzymatic catalysis12,13, have demonstrated their capacities for expanding the applications of enzymes in both academia and industry. However, the integration of electrochemistry with...
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作者：Pulupa, Joan; McArthur, Natalie G.; Stathi, Olga; Wang, Miao; Zazhytska, Marianna; Pirozzolo, Isabella D.; Nayar, Ahana; Shapiro, Lawrence; Lomvardas, Stavros
作者单位：Columbia University; Columbia University; Columbia University; Columbia University; Columbia University; Columbia University
摘要：Ultra-long-range genomic contacts, which are key components of neuronal genome architecture1, 2-3, constitute a biochemical enigma. This is because regulatory DNA elements make selective and stable contacts with DNA sequences located hundreds of kilobases away, instead of interacting with proximal sequences occupied by the exact same transcription factors1,4. This is exemplified in olfactory sensory neurons (OSNs), in which only a fraction of LHX2-, EBF1- and LDB1-bound sites interact with eac...
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作者：Li, Kai; Ott, Christian; Agaker, Marcus; Ho, Phay J.; Doumy, Gilles; Magunia, Alexander; Rebholz, Marc; Simon, Marc; Mazza, Tommaso; De Fanis, Alberto; Baumann, Thomas M.; Montano, Jacobo; Rennhack, Nils; Usenko, Sergey; Ovcharenko, Yevheniy; Chordiya, Kalyani; Cheng, Lan; Rubensson, Jan-Erik; Meyer, Michael; Pfeifer, Thomas; Gaarde, Mette B.; Young, Linda
作者单位：University of Chicago; United States Department of Energy (DOE); Argonne National Laboratory; Max Planck Society; Uppsala University; Lund University; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); European XFEL; University of Hamburg; Louisiana State University System; Louisiana State University; Johns Hopkins University; University of Chicago
摘要：Propagation of intense X-ray pulses through dense media has led to the observation of phenomena such as atomic X-ray lasing1,2, self-induced transparency3 and stimulated X-ray Raman scattering (SXRS)4. SXRS has been long predicted as a means to launch and probe valence-electron wavepackets and as a building block for nonlinear X-ray spectroscopies5,6. However, experimental observations of SXRS to date4,7,8 have not provided spectroscopic information, and theoretical modelling has largely imple...
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作者：Varghese, Alan; Gusarov, Ivan; Gamallo-Lana, Begona; Dolgonos, Daria; Mankan, Yatin; Shamovsky, Ilya; Phan, Mydia; Jones, Rebecca; Gomez-Jenkins, Maria; White, Eileen; Wang, Rui; Jones, Drew R.; Papagiannakopoulos, Thales; Pacold, Michael E.; Mar, Adam C.; Littman, Dan R.; Nudler, Evgeny
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作者：[Anonymous]
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作者：Kosicki, Michael; Zhang, Boyang; Hecht, Vivian; Pampari, Anusri; Cook, Laura E.; Slaven, Neil; Akiyama, Jennifer A.; Plajzer-Frick, Ingrid; Novak, Catherine S.; Kato, Momoe; Tran, Stella; Hunter, Riana D.; von Maydell, Kianna; Barton, Sarah; Beckman, Erik; Zhu, Yiwen; Dickel, Diane E.; Kundaje, Anshul; Visel, Axel; Pennacchio, Len A.
作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Stanford University; Stanford University; University of California System; University of California Merced; University of California System; University of California Berkeley
摘要：Distant-acting enhancers are central to human development1. However, our limited understanding of their functional sequence features prevents the interpretation of enhancer mutations in disease2. Here we determined the functional sensitivity to mutagenesis of human developmental enhancers in vivo. Focusing on seven enhancers that are active in the developing brain, heart, limb and face, we created over 1,700 transgenic mice for over 260 mutagenized enhancer alleles. Systematic mutation of 12-b...
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作者：Ahart, Jenna
摘要：Democrats hosted a protest event featuring 'things we'll never know' because of the US government's cuts to science.
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作者：Wild, Sarah
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作者：Zhou, Jingxuan; Zhou, Jingyuan; Wan, Zhong; Qian, Qi; Ren, Huaying; Yan, Xingxu; Zhou, Boxuan; Zhang, Ao; Pan, Xiaoqing; Fang, Wuzhang; Ping, Yuan; Sofer, Zdenek; Huang, Yu; Duan, Xiangfeng
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Chemistry & Technology, Prague; University of California System; University of California Los Angeles
摘要：Tailoring magnetic ordering in solid-state materials is essential for emerging spintronics1,2. However, substitutional lattice doping in magnetic semiconductors is often constrained by the low solubility of magnetic elements3, 4-5, limiting the maximum achievable doping concentration (for example, less than 5%) and ferromagnetic ordering temperature6. The intercalation of magnetic elements in layered two-dimensional atomic crystals (2DACs) without breaking in-plane covalent bonds offers an alt...
