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作者：Hauser, Oliver P.; Light, Miriam; Shelmerdine, Lizzie; Blumenau, Jack
作者单位：University of Exeter; University of London; University College London
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作者：Di Girolamo, Larry; Zhao, Guangyu; Zhang, Gan; Wang, Zhuo; Loveridge, Jesse; Mitra, Arka
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; Colorado State University System; Colorado State University Fort Collins
摘要：Changing atmospheric circulations shift global weather patterns and their extremes, profoundly affecting human societies and ecosystems. Studies using atmospheric reanalysis and climate model data1, 2, 3, 4, 5, 6, 7, 8-9 indicate diverse circulation changes in recent decades but show discrepancies in magnitude and even direction, underscoring the urgent need for validation with independent, climate-quality measurements3. Here we show statistically significant changes in tropospheric circulatio...
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作者：Milani, Michela; Fabiano, Anna; Perez-Rodriguez, Marta; Hernandez, Raisa Jofra; Zecchillo, Alessandra; Zonari, Erika; Ottonello, Sofia; Basso-Ricci, Luca; Canepari, Cesare; Volpin, Monica; Iannello, Valeria; Capo, Valentina; Quaranta, Pamela; Seffin, Luca; Russo, Fabio; Biffi, Mauro; Ormoli, Leonardo; Brombin, Chiara; Carlucci, Filippo; Forlino, Antonella; Filibian, Marta; Montini, Eugenio; Scala, Serena; Villa, Anna; Bueren, Juan Antonio; Rio, Paula; Aiuti, Alessandro; Cantore, Alessio; Naldini, Luigi
作者单位：Fondazione Telethon; San Raffaele Telethon Institute For Gene Therapy (Sr-Tiget); Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Centro de Investigaciones Energeticas, Medioambientales Tecnologicas; CIBER - Centro de Investigacion Biomedica en Red; CIBERER; University of Barcelona; University of Milano-Bicocca; Vita-Salute San Raffaele University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca Genetica e Biomedica (IRGB-CNR); Vita-Salute San Raffaele University; University of Siena; University of Pavia; University of Pavia
摘要：Lentiviral vector (LV)-mediated ex vivo gene therapy for haematopoietic stem and progenitor cells (HSPCs) has delivered on the promise of a 'one-and-done' treatment for several genetic diseases1. However, ex vivo manipulation and patient conditioning before transplantation are major hurdles that could be overcome by an in vivo approach. Here we demonstrate that in vivo gene delivery to HSPCs after systemic LV administration is enabled by the substantial trafficking of these cells from the live...
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作者：Smoliga, James
作者单位：Tufts University
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作者：Garisto, Dan; Witze, Alexandra
摘要：Committee gives first hint that policymakers might preserve, rather than slash, funding for US National Science Foundation and other agencies.
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作者：Sikora, Martin; Canteri, Elisabetta; Fernandez-Guerra, Antonio; Oskolkov, Nikolay; Agren, Rasmus; Hansson, Lena; Irving-Pease, Evan K.; Muehlemann, Barbara; Nielsen, Sofie Holtsmark; Scorrano, Gabriele; Allentoft, Morten E.; Seersholm, Frederik Valeur; Schroeder, Hannes; Gaunitz, Charleen; Stenderup, Jesper; Vinner, Lasse; Jones, Terry C.; Nystedt, Bjoern; Sjoegren, Karl-Goeran; Parkhill, Julian; Fugger, Lars; Racimo, Fernando; Kristiansen, Kristian; Iversen, Astrid K. N.; Willerslev, Eske
作者单位：University of Copenhagen; University of Copenhagen; University of Copenhagen; Lund University; Chalmers University of Technology; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; German Center for Infection Research; Statens Serum Institut; University of Rome Tor Vergata; Curtin University; University of Cambridge; Uppsala University; University of Gothenburg; University of Cambridge; University of Oxford; University of Oxford; University of Oxford; University of Cambridge; University of Bremen; University of Bremen
摘要：Infectious diseases have had devastating effects on human populations throughout history, but important questions about their origins and past dynamics remain1. To create an archaeogenetic-based spatiotemporal map of human pathogens, we screened shotgun-sequencing data from 1,313 ancient humans covering 37,000 years of Eurasian history. We demonstrate the widespread presence of ancient bacterial, viral and parasite DNA, identifying 5,486 individual hits against 492 species from 136 genera. Amo...
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作者：[Anonymous]
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作者：[Anonymous]
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作者：Novikov, Valeriy; Jia, Jun; Brasil, Tulio Brito; Grimaldi, Andrea; Bocoum, Maimouna; Balabas, Mikhail; Muller, Jorg Helge; Zeuthen, Emil; Polzik, Eugene Simon
作者单位：University of Copenhagen; Niels Bohr Institute; Russian Quantum Center; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite
摘要：Ultimate limits for the sensing of fields and forces are set by the quantum noise of a sensor1, 2-3. Entanglement allows for suppression of such noise and for achieving sensitivity beyond standard quantum limits4, 5, 6-7. Applicability of quantum optical sensing is often restricted by fixed wavelengths of available photonic quantum sources. Another ubiquitous limitation is associated with challenges of achieving quantum-noise-limited sensitivity in the acoustic noise frequency range relevant f...
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作者：Rogers, Todd; Shulman, Hillary
作者单位：Harvard University; University System of Ohio; Ohio State University
