8073期

最新文章

• Reply to: Experiments implementing small commuting models lack gravitational features AI翻译
  作者：Jafferis, Daniel; Zlokapa, Alexander; Lykken, Joseph D.; Kolchmeyer, David K.; Davis, Samantha I.; Neven, Hartmut; Spiropulu, Maria
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); California Institute of Technology; California Institute of Technology; Alphabet Inc.; Google Incorporated; United States Department of Energy (DOE); University of Chicago; Fermi National Accelerator Laboratory
• Rise of the planet of the zombie bugs AI翻译
  作者：Robinson, Andrew
• 'Controlled chaos': how to create an environment that fosters genius AI翻译
  作者：Maynard, Patrick
• Asia's haze affects ice and weather on the Frozen Continent AI翻译
  作者：[Anonymous]
• CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells AI翻译
  作者：Rafei, Hind; Basar, Rafet; Acharya, Sunil; Hsu, Yu-Sung; Liu, Pinghua; Zhang, Deqiang; Bohn, Toszka; Liang, Qingnan; Mohanty, Vakul; Upadhyay, Ranjan; Li, Ping; Phadatare, Pravin; Dede, Merve; Xiong, Donghai; Fan, Huihui; Jones, Corry Mathew; Kunz, Sebastian; Daher, May; Nunez Cortes, Ana Karen; Shanley, Mayra; Liu, Bin; Moseley, Sadie Mae; Zhang, Chenyu; Fang, Dexing; Banerjee, Pinaki; Uprety, Nadima; Li, Ye; Shrestha, Rejeena; Wan, Xinhai; Shen, Hong; Woods, Vernikka; Gilbert, April Lamour; Rawal, Seema; Dou, Jinzhuang; Tan, Yukun; Park, Jeong-Min; Reyes Silva, Francia; Biederstadt, Alexander; Kaplan, Mecit; Jiang, Xin Ru; Biederstadt, Inci; Kumar, Bijender; Tiberti, Silvia; Moore, Madison; Jin, Jingling; Yang, Ryan Z.; Muniz-Feliciano, Luis; Rosemore, Samuel; Lin, Paul; Deyter, Gary M.; Fowlkes, Natalie Wall; Jain, Abhinav K.; Marin, David; Maitra, Anirban; Chen, Ken; Bopp, Tobias; Shpall, Elizabeth J.; Rezvani, Katayoun
  作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Helmholtz Association; German Cancer Research Center (DKFZ); University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; University of Texas Health Science Center Houston; University of Texas System; UTMD Anderson Cancer Center; Technical University of Munich; University System of Maryland; University of Maryland College Park; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Johannes Gutenberg University of Mainz
  摘要：Chimeric antigen receptor (CAR) natural killer (NK) cell immunotherapy offers a promising approach against cancer1, 2-3. However, the molecular mechanisms that regulate CAR-NK cell activity remain unclear. Here we identify the transcription factor cyclic AMP response element modulator (CREM) as a crucial regulator of NK cell function. Transcriptomic analysis revealed a significant induction of CREM in CAR-NK cells during the peak of effector function after adoptive transfer in a tumour mouse m...
• Naturally ornate RNA-only complexes revealed by cryo-EM AI翻译
  作者：Kretsch, Rachael C.; Wu, Yuan; Shabalina, Svetlana A.; Lee, Hyunbin; Nye, Grace; Koonin, Eugene V.; Gao, Alex; Chiu, Wah; Das, Rhiju
  作者单位：Stanford University; Stanford University; Howard Hughes Medical Institute; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Division of Intramural Research (DIR); Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University
  摘要：The structures of natural RNAs remain poorly characterized and may hold numerous surprises1, 2, 3-4. Here we report three-dimensional structures of three large ornate bacterial RNAs using cryo-electron microscopy (cryo-EM). GOLLD (Giant, Ornate, Lake- and Lactobacillales-Derived), ROOL (Rumen-Originating, Ornate, Large) and OLE (Ornate Large Extremophilic) RNAs form homo-oligomeric complexes whose stoichiometries are retained at lower concentrations than measured in cells. OLE RNA forms a dime...
• Integrated biotechnological and AI innovations for crop improvement AI翻译
  作者：Li, Guotian; An, Linna; Yang, Wanneng; Yang, Lei; Wei, Tong; Shi, Jiawei; Wang, Jianglin; Doonan, John H.; Xie, Kabin; Fernie, Alisdair R.; Lagudah, Evans S.; Wing, Rod A.; Gao, Caixia
  作者单位：Hubei Hongshan Laboratory; Huazhong Agricultural University; University of Washington; University of Washington Seattle; Huazhong Agricultural University; Hubei Hongshan Laboratory; Beijing Genomics Institute (BGI); UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Institute of Biological, Environmental, Rural & Sciences (IBERS); Aberystwyth University; Max Planck Society; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Agriculture & Food; King Abdullah University of Science & Technology; University of Arizona; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Crops provide food, clothing and other important products for the global population. To meet the demands of a growing population, substantial improvements are required in crop yield, quality and production sustainability. However, these goals are constrained by various environmental factors and limited genetic resources. Overcoming these limitations requires a paradigm shift in crop improvement by fully leveraging natural genetic diversity alongside biotechnological approaches such as genome e...
• There's a new acid in our rain - should we be worried? AI翻译
  作者：Lim, Xiaozhi
• Rapid emergence of a maths gender gap in first grade AI翻译
  作者：Martinot, P.; Colnet, B.; Breda, T.; Sultan, J.; Touitou, L.; Huguet, P.; Spelke, E.; Dehaene-Lambertz, G.; Bressoux, P.; Dehaene, S.
  作者单位：Universite Paris Cite; Universite Paris Saclay; CEA; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS); Paris School of Economics; Centre National de la Recherche Scientifique (CNRS); Universite Clermont Auvergne (UCA); Universite Clermont Auvergne (UCA); Centre National de la Recherche Scientifique (CNRS); Harvard University; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Universite PSL; College de France
  摘要：Preventing gender disparities in mathematics is a worldwide preoccupation1,2. In infancy and early childhood, boys and girls exhibit similar core knowledge of number and space3, 4, 5, 6, 7-8. Gender disparities in maths are, therefore, thought to primarily reflect an internalization of the sociocultural stereotype that 'girls are bad at maths'. However, where, when and how widely this stereotype becomes entrenched remains uncertain. Here, we report the results of a 4-year longitudinal assessme...
• Encouraging a 'data sufficiency' mindset is key for responsible research AI翻译
  作者：Heeren, Alexandre
  作者单位：Universite Catholique Louvain